“…In this context, decades of advances in membrane technology have led to its application in neuroscience and neural engineering. Several papers indicated that membrane-based systems provide in vitro advanced devices that enhance neuronal growth and differentiation and enable the repair and regeneration of the nervous system [De Bartolo et al, 2008;Morelli et al, 2010Morelli et al, , 2015bMorelli et al, , 2017a. In addition, neuronal biohybrid membrane systems can mimic specific features of the in vivo neuronal environment and, therefore, are also widely used as in vitro brain tissue models for pharmacological screening and as investigational platform for neurodegenerative diseases [Giusi et al, 2009;Morelli et al, 2014Morelli et al, , 2016Morelli et al, , 2019Morelli et al, , 2021Piscioneri et al, 2015Piscioneri et al, , 2021Mele et al, 2017].…”