Neuronal Effects of Sugammadex in combination with Rocuronium or Vecuronium

Aldasoro, Martı́n; Vallés, Soraya L; Aldasoro, Constanza; Marchio, Patricia; Guerra-Ojeda, Sol; Gimeno-Raga, Marc; Mauricio, Maria D.; Iradi, Antonio; Obrador, Elena; Vila, José M.; Valles, Soraya L.

doi:10.7150/ijms.17545

Cited by 10 publications

(9 citation statements)

References 47 publications

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“…although it is thought to increase in situations such as trauma, it is not possible to transfer sugammadex to cerebral cells as intensely as in this study. Cerebral cell cultures were kept in vitro with sugammadex solution and apoptosis was examined by Aldasoro et al 23 In this study, no statistically significant difference has been observed between the groups receiving sugammadex and the group receiving mannitol after trauma in terms of neuronal density. Furthermore, NeuN and activated CASP3 positive cells were low.…”

Section: Discussionmentioning

confidence: 69%

Evaluation of Neuroprotective Effects of Sugammadex Following a Head Trauma in an Experimental Study

Muçuoğlu

Mucuoglu

Kızmazoğlu

et al. 2021

Journal of Craniofacial Surgery

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To compare the efficacy of mannitol, the first choice of treatment in daily clinical practice for head trauma, and sugammadex, a frequently used neuroanesthesia in recent years. A total of 35 male rats were randomly selected and were divided into 5 groups, each comprising 7 rats. The groups were divided into Group I, sham (n ¼ 7); Group II, control (head trauma, n ¼ 7); Group III, treated with mannitol (head trauma, mannitol 20% 1 g/kg, n ¼ 7); Group IV, treated with sugammadex (head trauma, sugammadex 100 mg/ kg, n ¼ 7); and Group V, treated with mannitol and sugammadex (head trauma, mannitol 20% 1 g/kg and sugammadex 100 mg/kg, n ¼ 7). After the sacrification, histological examination and immunohistochemical staining were performed in the brain of all subjects. Mann-Whitney U test was used to evaluate the significance between neuronal density, neuronal nuclei, and activated caspase-3 immunohistochemistry results measured from the prefrontal cortex. Neuronal density showing neuronal viability was observed to significantly increase in Group III compared to Group IV. However, neuronal nuclei immunohistochemistry showing apoptotic neurons also significantly increased. The present study has shown that sugammadex, an agent reversing the effects of neuromuscular blocking agents, has neuroprotective effects and is as effective as mannitol.

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Section: Discussionmentioning

confidence: 69%

Evaluation of Neuroprotective Effects of Sugammadex Following a Head Trauma in an Experimental Study

Muçuoğlu

Mucuoglu

Kızmazoğlu

et al. 2021

Journal of Craniofacial Surgery

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“…Reversal of neuromuscular blockage induced by steroidal neuromuscular blocking agents such as rocuronium can be achieved using normal dose of sugammadex. Intravenous sugammadex demonstrates linear pharmacokinetic properties over the dose range of 1-16 mg/kg [24] . Therefore, 16 mg/kg sugammadex were given to rats in our study.…”

Section: Discussionmentioning

confidence: 99%

Ratlarda Sugammadex ve Rocuronium Kombinasyonunun Kraniyal Nörotoksisite Üzerine Etkisi: Deneysel Çalışma

Uludağ¹

2019

Kafkas Univ Vet Fak Derg

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Sugammadex is frequently used in clinical anesthetic practice. In order to determine whether sugammadex has neurotoxic effect, histopathological evaluation and antioxidant status of brain and cerebellum tissues were investigated. Thirty-two adult sprague dawley rats were divided into four groups. Purine Control Group (Group 1, n=8) had no action. The control group (Group 2, n=8) received 16 mg/ kg serum physiologic, the sugammadex group (Group 3, n=8) received 16 mg/kg sugammadex and the sugammadex+rocuronium group (Group 4, n=8) received 16 mg/kg sugammadex and 1 mg/kg rocuronium. After drug administration, brain and cerebellum tissues were evaluated histological and biochemically for and oxidative damage. The overall structure of the brain and cerebellum tissues were normal in all groups. Images of the layers and the neurons contained there in were normal. No pathological findings were found. There had no statistically significant difference between the groups in terms of glutathione enzyme activity levels (GSH-Px) and the malondialdehyde (MDA) levels in rat brain. GSH-Px and MDA levels had a slight increase in sugammadex and sugammadex+rocuronium group in cerebellum tissues. These increases were statistically significant. But this increase did not cause any histopathological damage to the cerebellum tissue. The study demonstrates that sugammadex is safe for reversal of rocuronium effects in rats. Sugammadex in the dose ranges used in the studies, did not produce adverse effects in rats brain and cerebellum tissues.

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“…Research into Rb and Vb mainly refers to its effects on neurones (24)(25)(26), but wider effects have not been investigated in vitro. Thus, it is important to study the effect of muscle-relaxant anesthetics, especially Rb, Vb or CB, on tumor metastasis both in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Different Muscle-Relaxant Anesthetics on Growth, Migration and Invasion of Gastric Cancer Cells

Jiang

Zhao

Liu

et al. 2017

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Neuronal Effects of Sugammadex in combination with Rocuronium or Vecuronium

Cited by 10 publications

References 47 publications

Evaluation of Neuroprotective Effects of Sugammadex Following a Head Trauma in an Experimental Study

Evaluation of Neuroprotective Effects of Sugammadex Following a Head Trauma in an Experimental Study

Ratlarda Sugammadex ve Rocuronium Kombinasyonunun Kraniyal Nörotoksisite Üzerine Etkisi: Deneysel Çalışma

Comparison of Different Muscle-Relaxant Anesthetics on Growth, Migration and Invasion of Gastric Cancer Cells

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