Neuronal figure-ground responses in primate primary auditory cortex

Schneider, Felix; Balezeau, Fabien; Distler, C.; Kikuchi, Y.; Kempen, Jochem van; Gieselmann, Alwin; Petkov, Christopher I.; Thiele, Alexander; Griffiths, Timothy D.

doi:10.1016/j.celrep.2021.109242

Cited by 11 publications

(3 citation statements)

References 57 publications

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“…Tone-cloud stimuli similar to the sounds employed in this study have been used with functional MRI, MEG, and electroencephalography to probe auditory figure–ground segregation in typical adults. These studies showed that although evidence of temporal coherence processing is measurable in the auditory cortex, attention can significantly enhance the neural representation of the foreground figure, especially in later parietal regions [ 32 , 34 , 56 , 57 ]. Indeed, animal models show that temporal coherence sensitivity and neural computations that support auditory scene analysis begin subcortically, as early as the cochlear nucleus [ 58 ].…”

Section: Discussionmentioning

confidence: 99%

Cortical signatures of auditory object binding in children with autism spectrum disorder are anomalous in concordance with behavior and diagnosis

Bharadwaj

Mamashli²,

Khan³

et al. 2022

PLoS Biol

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Organizing sensory information into coherent perceptual objects is fundamental to everyday perception and communication. In the visual domain, indirect evidence from cortical responses suggests that children with autism spectrum disorder (ASD) have anomalous figure–ground segregation. While auditory processing abnormalities are common in ASD, especially in environments with multiple sound sources, to date, the question of scene segregation in ASD has not been directly investigated in audition. Using magnetoencephalography, we measured cortical responses to unattended (passively experienced) auditory stimuli while parametrically manipulating the degree of temporal coherence that facilitates auditory figure–ground segregation. Results from 21 children with ASD (aged 7–17 years) and 26 age- and IQ-matched typically developing children provide evidence that children with ASD show anomalous growth of cortical neural responses with increasing temporal coherence of the auditory figure. The documented neurophysiological abnormalities did not depend on age, and were reflected both in the response evoked by changes in temporal coherence of the auditory scene and in the associated induced gamma rhythms. Furthermore, the individual neural measures were predictive of diagnosis (83% accuracy) and also correlated with behavioral measures of ASD severity and auditory processing abnormalities. These findings offer new insight into the neural mechanisms underlying auditory perceptual deficits and sensory overload in ASD, and suggest that temporal-coherence-based auditory scene analysis and suprathreshold processing of coherent auditory objects may be atypical in ASD.

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Section: Discussionmentioning

confidence: 99%

Cortical signatures of auditory object binding in children with autism spectrum disorder are anomalous in concordance with behavior and diagnosis

Bharadwaj

Mamashli²,

Khan³

et al. 2022

PLoS Biol

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“…For auditory stimuli, figure-ground perception is not exclusive to humans; it has also been observed in animals, in studies on figure-ground processes investigated through noise and sound. Extracellular recordings demonstrated increased multiunit activities in the auditory area 57 . Further, auditory areas have been the focus of previous human studies on stream segregation through selective attention and figure-ground segregation 46,47,49,51 .…”

Section: Discussionmentioning

confidence: 98%

Bidirectional connectivity changes in the frontotemporal areas reflect figure–ground reversal in multivoiced music

Kim,

Seo,

Chung

2024

Preprint

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The neural processes underlying the perception of prominently heard voices (figure) and less prominently heard voices (ground), particularly when this prominence is naturally reversed while listening to music, remain inadequately investigated. We investigated changes in frontotemporal connectivity in response to figure-ground reversal within multivoiced music using Mozart's variation KV 265, including the "Twinkle, Twinkle, Little Star (TTLS)" melody based on our previous study of frontotemporal connectivity (TTLS connectivity), influenced by the emergence of the TTLS melody in the upper voice at the beginning of each variation, and independent of lower voices. We examined the consistency of the TTLS connectivity pattern across repetitions of the same phrases within each variation. Notably, TTLS connectivity changed only for the final repetition between variations sharing the same TTLS melody. This result indicates a perceptual reversal, processing the TTLS melody initially perceived as figure into the ground. Our data effectively illustrate how the brain dissects voices within the multidimensional structures of continuously changing music, reconstructing them through a momentary switch in figure-ground processes. These findings provide valuable insights into the neural processes associated with the dynamic experience of listening to music, a ubiquitous aspect of human life.

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“…The model allows systematic neurophysiology in a way that would never be possible in humans. Recordings of multiunit activity demonstrate tonic responses to figure onset that are present in all three auditory core areas in the superior temporal plane ( Schneider et al, 2021 ). We can also carry out fMRI in the macaque to measure BOLD activity in neuronal ensembles: this allows a direct comparison with human studies.…”

Section: Brain Mechanisms For Auditory Cognition Relevant To Speech-i...mentioning

confidence: 99%

Predicting speech-in-noise ability in normal and impaired hearing based on auditory cognitive measures

Griffiths

2023

Front. Neurosci.

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Problems with speech-in-noise (SiN) perception are extremely common in hearing loss. Clinical tests have generally been based on measurement of SiN. My group has developed an approach to SiN based on the auditory cognitive mechanisms that subserve this, that might be relevant to speakers of any language. I describe how well these predict SiN, the brain systems for them, and tests of auditory cognition based on them that might be used to characterise SiN deficits in the clinic.

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Neuronal figure-ground responses in primate primary auditory cortex

Abstract: Highlights d Neuronal figure-ground modulation in primary auditory cortex d A rate code is used to signal the presence of auditory figures d Anteriorly located recording sites encode perceptual saliency d Figure-ground modulation is present without perceptual detection

Cited by 11 publications

References 57 publications

Cortical signatures of auditory object binding in children with autism spectrum disorder are anomalous in concordance with behavior and diagnosis

Cortical signatures of auditory object binding in children with autism spectrum disorder are anomalous in concordance with behavior and diagnosis

Bidirectional connectivity changes in the frontotemporal areas reflect figure–ground reversal in multivoiced music

Predicting speech-in-noise ability in normal and impaired hearing based on auditory cognitive measures

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