2024
DOI: 10.1111/jnc.16279
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Neuronal growth regulator 1 (NEGR1) promotes the synaptic targeting of glutamic acid decarboxylase 65 (GAD65)

Feifei Su,
Grant Pfundstein,
Saroj Sah
et al.

Abstract: Neuronal growth regulator 1 (NEGR1) is a synaptic plasma membrane localized cell adhesion molecule implicated in a wide spectrum of psychiatric disorders. By RNAseq analysis of the transcriptomic changes in the brain of NEGR1‐deficient mice, we found that NEGR1 deficiency affects the expression of the Gad2 gene. We show that glutamic acid decarboxylase 65 (GAD65), the Gad2 ‐ encoded enzyme synthesizing the inhibitory neurotransmitter GABA on synaptic vesicles, accumulates non‐synaptically in brains of NEGR1‐de… Show more

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