Neuronal Laterality in Parkinson's Disease With Unilateral Symptom by In Vivo 1H Magnetic Resonance Spectroscopy

Choe, Bo-Young; Park, Jeong‐Wook; Lee, Kwang-Soo; Son, Byung-chul; Kim, Moon-Chan; Kim, Bum Soo; Suh, T; Lee, Hyoung-Koo; Shinn, Kyung Sub

doi:10.1097/00004424-199808000-00005

Cited by 52 publications

(42 citation statements)

References 17 publications

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“…Many researchers disclosed a significant reduction of ratios NAA/Cr and NAA/Cho in the temporoparietal cortex [91], the substantia nigra, the basal ganglia [92], the striatum or the occipital lobe [93]. Griffith et al have demonstrated lower NAA/Cr ratios in the posterior cingulate gyrus of demented versus non demented subjects with PD [94].…”

Section: Neurodegenerative Diseases (Alzheimer/parkinson)mentioning

confidence: 99%

Proton Magnetic Resonance Spectroscopy of the Central Nervous System

Kousi¹,

Tsougos²,

Eftychia³

2013

Novel Frontiers of Advanced Neuroimaging

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Section: Neurodegenerative Diseases (Alzheimer/parkinson)mentioning

confidence: 99%

Proton Magnetic Resonance Spectroscopy of the Central Nervous System

Kousi¹,

Tsougos²,

Eftychia³

2013

Novel Frontiers of Advanced Neuroimaging

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“…Choe et al. (1998) demonstrated reduced NAA/Cr in PD patients and Holshouser et al. (1995) demonstrated significantly reduced NAA/Cho ratio in PD patients, and researchers have demonstrated that the level of NAA may reflect the status of neuron function.…”

Section: Discussionmentioning

confidence: 95%

Detection and application of neurochemical profile by multiple regional ¹H‐MRS in Parkinson's disease

Guan

Wen

et al. 2017

Brain and Behavior

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IntroductionThe accurate diagnosis and monitoring of idiopathic Parkinson disease (PD), a progressive neurodegenerative disorder, has not been fully developed. This study sought to identify a neurochemical profile in multiple regions of the PD brain and healthy controls by proton magnetic resonance spectroscopy (1H‐MRS). We aimed to track changes of the brain neurochemical, quantify neuronal loss, and further determine the diagnostic value of 1H‐MRS.Methods PD patients and healthy controls recruited from Second Affiliated Hospital of Shantou University Medical College, Shantou, southern China, underwent 1H‐MRS. Chemical information was obtained for ratios of N‐acetylaspartate to creatine (NAA/Cr), NAA to choline (NAA/Cho), and Cho to Cr for substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus, and dorsal thalamus regions.ResultsCompared to the 20 healthy controls (12 male, age 58.75 ± 5.03 years), the 42 patients (21 male, age 61.60 ± 6.40 years) showed lower NAA/Cr and NAA/Cho ratios in substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus and dorsal thalamus regions (p < .01); NAA/Cr and NAA/Cho ratios were reduced for both patients with unilateral and mild/no cognitive impairment (p < .01); Unified Parkinson's Disease Rating Scale score was inversely correlated with NAA/Cr ratios in the substantia nigra (r = −.32; p = .042).Conclusion NAA/Cr and NAA/Cho ratios may be useful metabolic biomarkers for early diagnosis of PD. Multi‐voxel 1H‐MRS can provide information on brain neurochemistry and may be a promising technique for diagnosis of and monitoring neuronal loss in PD.

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“…Abnormal metabolite levels have been demonstrated in motor cortex, 20 presupplementary motor area, 21 temporoparietal cortex, 22 occipital lobe, and lentiform nucleus and striatum. 8,12,15,21,23 Some changes have taken place in association with medications administered for treatment of PD that resulted in increased motor cortex Cho/Cr ratios. 12, 24 Griffith and colleagues, 25 have demonstrated lower NAA/Cr ratios in the posterior cingulate gyrus of demented versus non demented subjects with PD.…”

Section: Discussionmentioning

confidence: 99%

Magnetic resonance spectroscopy imaging of medulla oblongata and substantia nigra in idiopathic Parkinson's disease

Rana

Guo

et al. 2013

Asian J Med Sci

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Objective: To use 1.5T 1H-MRS as a research tool in vivo and demonstrate the feasibility of obtaining long-echo 1H MR spectra in small volumes like substantia nigra (SN) and medulla oblongata (MO) in healthy volunteers and patients with Parkinson's disease (PD) and observe the clinical correlations. Subjects and Methods:Twenty patients of the idiopathic Parkinson's disease (IPD) were recruited from the Out Patient Department of Neurology. Additionally, 14 age-matched healthy subjects were taken as controls group. After baseline evaluation, the patients satisfying inclusion and exclusion criteria underwent 1H-MRS study. All MR examinations were performed on a 1.5 T system (Philips Gyroscan Intera, Netherlands) using a standard quadrature head coil. Results:We succeeded to achieve 74.19% and 77.42% of spectra from MO and SN of both PD and control groups. MO showed slightly weak negative result to total UPDRS and UPDRS-II, but no significant correlation was found between metabolites and clinical indexes in MO. The result also showed no significant correlations between H&Y scale and metabolites in MO and SN of PD patients. But there was a significant correlation between H&Y, NAA/Cr and Cho/Cr in SN.Conclusions: MRS ratios from MO and SN does not play any significant role to differentiate PD from the normal subjects, but metabolites ratios from SN of PD patient can help to understand the progression and severity of the disease. Therefore, it is not practical to employ MRS as a diagnostic tool for PD.

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Neuronal Laterality in Parkinson's Disease With Unilateral Symptom by In Vivo 1H Magnetic Resonance Spectroscopy

Cited by 52 publications

References 17 publications

Proton Magnetic Resonance Spectroscopy of the Central Nervous System

Proton Magnetic Resonance Spectroscopy of the Central Nervous System

Detection and application of neurochemical profile by multiple regional ¹H‐MRS in Parkinson's disease

Magnetic resonance spectroscopy imaging of medulla oblongata and substantia nigra in idiopathic Parkinson's disease

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Neuronal Laterality in Parkinson's Disease With Unilateral Symptom by In Vivo 1H Magnetic Resonance Spectroscopy

Cited by 52 publications

References 17 publications

Proton Magnetic Resonance Spectroscopy of the Central Nervous System

Proton Magnetic Resonance Spectroscopy of the Central Nervous System

Detection and application of neurochemical profile by multiple regional 1H‐MRS in Parkinson's disease

Magnetic resonance spectroscopy imaging of medulla oblongata and substantia nigra in idiopathic Parkinson's disease

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Detection and application of neurochemical profile by multiple regional ¹H‐MRS in Parkinson's disease