Neuronal localization and modulation of the D2 dopamine receptor mRNA in brain of normal mice and mice lesioned with 6-hydroxydopamine

Adaptive changes in the rat dopaminergic transmission following repeated lithium administration

“…Also, the alterations at the level of mRNA begin to be statistically significant following longer periods of lithium administration, at a time when DA release is stabilized at a new, lower level. It has already been shown using DA depletion (midbrain 6-OHDA lesions or reserpine treatment) or pharmacological blockade of DA receptors with neuroleptics (Angulo et al, 1991;Bernard et al, 1991;Chen et al, 1991Chen et al, , 1993Coirini et al, 1990;Gerfen et al, 1990;Jaber et al, 1992Jaber et al, , 1994Srivastava et al, 1990) that dopaminergic transmission indeed regulates the level of mRNA coding for D2 receptor, by exerting tonic inhibition on dopamine D2 mRNA. Unfortunately, up to the present it was not possible to unequivocally show any effects of lithium, at "therapeutic" doses, on the parameters characteristic for ligand binding to DA receptors.…”

“…Since it has been already established that dopaminergic transmission regulates the levels of D2 receptors by exerting a tonic inhibition on its mRNA (Angulo et al, 1991;Bernard et al, 1991;Chen et al, 1991Chen et al, , 1993Coirini et al, 1990;Gerfen et al, 1990;Jaber et al, 1992Jaber et al, , 1994Srivastava et al, 1990), the studies were carried out to determine the effects of repeated lithium administration on the level of the mRNA coding for D2 receptor, using in situ hybridization.…”

The somatodendritic release of dopamine in the ventral tegmental area and its regulation by afferent transmitter systems

“…A role for the D 3 subtype as autoreceptor has been proposed based on its ability to inhibit in vivo dopaminergic cell firing in the VTA [116]. In addition, lesion studies revealed that the great majority of D2 receptors in the VTA are located in dopaminergic neurons [109,111,117]. Nevertheless, recent studies have revealed that the VTA of monkeys and humans do not express D 2 receptor mRNA [85,118], which suggests that in primates, the dopaminergic neurons of the VTA may be differently autoregulated.…”

Differential perikaryal localization in rats of D1 and D2 dopamine receptors on striatal projection neuron types identified by retrograde labeling

“…Among these genes, D1 and D2 are the most heavily expressed in the striatal part of the basal ganglia and are the main dopamine receptors that mediate the responses of striatal neurons to the dopaminergic input from the midbrain (Bouthenet et al, 1991;Civelli et al, 1991;Van Tol et al, 1991). The cellular localization of D1 and D2 dopamine receptors in the striatum has been studied using in situ hybridization histochemistry (ISHH), single-cell reverse transcription-polymerase chain reaction (RT-PCR), and immunohistochemistry (Mengod et al, 1989;Dearry et al, 1990;Gerfen et al, 1990;Le Moine et al, 1990, 1991Weiner et al, 1990Weiner et al, , 1991Chen et al, 1991;Lester et al, 1993). By ISHH and immunolabeling, D1 has been found to be expressed in about half and D2 in slightly more than half of striatal neurons (Weiner et al, 1990(Weiner et al, , 1991Meador-Woodruff et al, 1991;Huang et al, 1992;Levey et al, 1993;Hersch et al, 1995;Le Moine and Bloch, 1995;Yung et al, 1995;Ince et al, 1997;Lei et al, 2004).…”