Neuronal plasticity in memory and learning abilities: Theoretical position and selective review

Excessive compensatory recruitment as a compulsory neurophysiological mechanism in Very Early Alzheimer's Disease as compared to Mild Vascular Dementia and to age-matched normal controls

“…The present findings provide support for the theoretical position of the existence of neurophysiological mechanisms of excessive compensatory recruitment of neuronal pools in VEAD as opposed to normal aging processes (Beuzeron- Mangina andMangina, 2000b, 2008;Mangina and Sokolov, 2006). Moreover, the psychophysiological differentiation of VEAD from MVD and normal aging with the Topographic Mapping of ERPs to our Memory Workload Paradigm, provides distinct biological markers.…”

“…Thus, the lack of recruitment found in our MVD patients might also be explained by the fact that these long neuronal pathways were sufficiently preserved to allow patients to process the demanding memory load tasks of our paradigm without excessive physiological effort as opposed to VEAD patients. Hence, it is plausible that in VEAD, the excessive recruitment of compensatory neuronal pools becomes a compulsory neurophysiological mechanism to meet the demanding tasks of our Memory Workload Paradigm (Beuzeron- Mangina and Mangina, 1998, 2000a,b, 2004, 2008, Mangina and Sokolov, 2006. In fact, in our pilot investigations, the phenomenon of a compensatory recruitment was observable only in the very early stages Alzheimer's disease, and it was not visible in the more advanced stages of this illness.…”

An Association Study of the Genetic Polymorphisms in 13 Neural Plasticity-Related Genes with Semantic and Episodic Memories

“…Neural plasticity was a set of neural activities for the brain to reorganize neural pathways based on new experiences. Those neural activities occurred widely in various regions of cerebral cortex and played multiplex roles in various cognitions, behaviors, and mental activities (Mangina and Sokolov 2006;Wang et al 2006). Furthermore, most of the genes encoding neurotrophic properties or neurotransmitters exerted their effects in specific brain areas.…”

The usefulness of Psychophysiology in the maintenance of cognitive life

“…Electrical stimulation of deep brain structures provided new data on the brain control of the electrodermal phenomena modulated by ipsilateral limbic structures (Mangina, 1997;BeuzeronMangina, 1996, 2004;Mangina and Sokolov 2006).…”

“…Existing connections in the brain become activated and it is reasonable to assume that new ones are forming (even due to the proteins adhering) (Chavis and Westbrook, 2001;Schmidt-Hieber et al, 2004). It is worth mentioning that the possibility of altering beneficially the ultrastructural morphology, chemistry, and electrophysiology of neuronal pools in processing and learning information can be found in Mangina 1991; Mangina and Beuzeron-Mangina, 1992a,b;Beuzeron-Mangina, 1996, 2004;Mangina and Sokolov, 2006).…”