Neuronal proliferation in the 9-month-old rodent ? Radioautographic study of granule cells in the hippocampus

Kaplan, Max; Bell, Danny H.

doi:10.1007/bf00237141

Cited by 156 publications

(54 citation statements)

References 25 publications

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“…They receive synaptic input (Kaplan and Hinds, 1977;Kaplan and Bell, 1983;Markakis and Gage, 1999;Carlén et al, 2002), send axonal projections to appropriate targets in hippocampal area CA3 (Stanfield and Trice, 1988;Hastings and Gould, 1999;Markakis and Gage, 1999), and acquire the electrophysiological properties of mature granule neurons (Wang et al, 2000;Song et al, 2002b;van Praag et al, 2002). Although the precise function of DGCs generated in adulthood is unknown, experimental depletion of new neurons disrupts the formation of some types of memory (Shors et al, 2001), suggesting that the new neurons play a role in hippocampal-dependent learning and memory.…”

Section: Dentate Gyrusmentioning

confidence: 99%

Adult Neurogenesis and the Ischemic Forebrain

Lichtenwalner

Parent

2005

J Cereb Blood Flow Metab

262

190

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The recent identification of endogenous neural stem cells and persistent neuronal production in the adult brain suggests a previously unrecognized capacity for self-repair after brain injury. Neurogenesis not only continues in discrete regions of the adult mammalian brain, but new evidence also suggests that neural progenitors form new neurons that integrate into existing circuitry after certain forms of brain injury in the adult. Experimental stroke in adult rodents and primates increases neurogenesis in the persistent forebrain subventricular and hippocampal dentate gyrus germinative zones. Of greater relevance for regenerative potential, ischemic insults stimulate endogenous neural progenitors to migrate to areas of damage and form neurons in otherwise dormant forebrain regions, such as the neostriatum and hippocampal pyramidal cell layer, of the mature brain. This review summarizes the current understanding of adult neurogenesis and its regulation in vivo, and describes evidence for stroke-induced neurogenesis and neuronal replacement in the adult. Current strategies used to modify endogenous neurogenesis after ischemic brain injury also will be discussed, as well as future research directions with potential for achieving regeneration after stroke and other brain insults.

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Section: Dentate Gyrusmentioning

confidence: 99%

Adult Neurogenesis and the Ischemic Forebrain

Lichtenwalner

Parent

2005

J Cereb Blood Flow Metab

262

190

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“…Later, additional neurones are recruited along life span but specially during the juvenile periods of life (Bayer et al 1982, Kaplan andBell 1983). In primates, there is even more delay in the ontogenesis of their fascia dentata as postnatal neurogenesis continues for the first three postnatal months (Eckenhoff and Rakic 1988, Rakic and Nowakowski 1981, Kornack and Rakic 1999.…”

Section: Postnatal Neurogenesismentioning

confidence: 99%

The lizard cerebral cortex as a model to study neuronal regeneration

López‐García

Molowny

Nácher

et al. 2002

An. Acad. Bras. Ciênc.

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The medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayed postnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons, which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axons directed to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zincenriched axonal projection. This happens along the lizard life span, even in adult lizards, thus allowing one of their most important characteristics: neuronal regeneration. Experiments in our laboratory have shown that chemical lesion of the medial cortex (affecting up to 95% of its neurons) results in a cascade of events: first, massive neuronal death and axonal-dendritic retraction and, secondly, triggered ependymal-neuroblast proliferation and subsequent neo-histogenesis and regeneration of an almost new medial cortex, indistinguishable from a normal undamaged one. This is the only case to our knowledge of the regeneration of an amniote central nervous centre by new neuron production and neo-histogenesis. Thus the lizard cerebral cortex is a good model to study neuronal regeneration and the complex factors that regulate its neurogenetic, migratory and neo-synaptogenetic events.

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“…RAR, RXR, and RA activity occur in distinct patterns in the mature CNS including the dentate gyrus (DG), a hippocampal region distinguished as being one of the few sites of ongoing proliferation and neuronal development in the adult CNS (11)(12)(13)(14)(15)(16)(17). RA is necessary for long-term synaptic plasticity between neurons in the hippocampal Schaffer Collateral pathway (11,18), but the localized and intense concentration of RA and expression of RAR and RXR in the adult DG suggests that retinoids could also contribute to the region-specific phenomenon of neurogenesis.…”

mentioning

confidence: 99%

Retinoic acid is required early during adult neurogenesis in the dentate gyrus

Jacobs

Lie

DeCicco

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

240

180

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Retinoic acid (RA) is commonly used in vitro to differentiate stem cell populations including adult neural stem cells into neurons; however, the in vivo function of RA during adult neurogenesis remains largely unexplored. We found that depletion of RA in adult mice leads to significantly decreased neuronal differentiation within the granular cell layer of the dentate gyrus. RA contribution to neurogenesis occurs early, for RA deficiency also results in a decrease in newborn cells expressing an immature neuronal marker. Furthermore, although proliferation is unaffected during RA absence, cell survival is significantly reduced. Finally, a screen for retinoid-induced genes identifies metabolic targets including the lipid transporters, CD-36 and ABCA-1, the lipogenic master regulator SREBP1c as well as components of the Wnt signaling pathway. Our results reveal RA as a crucial contributor to early stages of adult neurogenesis and survival in vivo.hippocampus ͉ neural stem cells ͉ retinoic acid receptor ͉ vitamin A

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Neuronal proliferation in the 9-month-old rodent ? Radioautographic study of granule cells in the hippocampus

Cited by 156 publications

References 25 publications

Adult Neurogenesis and the Ischemic Forebrain

Adult Neurogenesis and the Ischemic Forebrain

The lizard cerebral cortex as a model to study neuronal regeneration

Retinoic acid is required early during adult neurogenesis in the dentate gyrus

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