Neuronal Regeneration from Ependymo-Radial Glial Cells: Cook, Little Pot, Cook!

Becker, Catherina G.; Becker, Thomas

doi:10.1016/j.devcel.2015.01.001

Cited by 86 publications

(90 citation statements)

References 141 publications

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“…In the zebrafish brain, radial glia-like stem and progenitor cells are thought to be the predominant stem cell type in homeostasis and after injury (Kroehne et al, 2011;Kizil et al, 2012;Barbosa et al, 2015;Becker and Becker, 2015;Than-Trong and Bally-Cuif, 2015). Here, we report that radial glia-like cells play only a minor part in adult cerebellar neurogenesis and in recovery after injury.…”

Section: Regenerative Potential In Zebrafish Reflects Adult Neurogenesismentioning

confidence: 72%

Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration

et al. 2017

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Zebrafish can regenerate after brain injury, and the regenerative process is driven by resident stem cells. Stem cells are heterogeneous in the vertebrate brain, but the significance of having heterogeneous stem cells in regeneration is not understood. Limited availability of specific stem cells might impair the regeneration of particular cell lineages. We studied regeneration of the adult zebrafish cerebellum, which contains two major stem and progenitor cell types: ventricular zone and neuroepithelial cells. Using conditional lineage tracing we demonstrate that cerebellar regeneration depends on the availability of specific stem cells. Radial glia-like cells are thought to be the predominant stem cell type in homeostasis and after injury. However, we find that radial glia-like cells play a minor role in adult cerebellar neurogenesis and in recovery after injury. Instead, we find that neuroepithelial cells are the predominant stem cell type supporting cerebellar regeneration after injury. Zebrafish are able to regenerate many, but not all, cell types in the cerebellum, which emphasizes the need to understand the contribution of different adult neural stem and progenitor cell subtypes in the vertebrate central nervous system.

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Section: Regenerative Potential In Zebrafish Reflects Adult Neurogenesismentioning

confidence: 72%

Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration

et al. 2017

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“…Increased proliferation of SOX2 + cells upon spinal cord injury is a common feature among vertebrates (Becker and Becker, 2015). In zebrafish (Hui et al, 2010, 2015), Xenopus (Gaete et al, 2012), mouse (Lacroix et al, 2014) and axolotl (this work, Rodrigo Albors et al, 2015; Holtzer, 1956) traumatic spinal cord injury triggers a long-range wave of increased cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

“…Neural stem cells exist in the spinal cord of all vertebrates, but only in salamanders these cells are mobilized efficiently to resolve spinal cord injuries (Becker and Becker, 2015; Tanaka and Ferretti, 2009). In axolotls, this is best exemplified following tail amputation, when cells adjacent to the cut end regrow a fully functional spinal cord (Holtzer, 1956; Mchedlishvili et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls

Rost

Albors

Mazurov

et al. 2016

eLife

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Axolotls are unique in their ability to regenerate the spinal cord. However, the mechanisms that underlie this phenomenon remain poorly understood. Previously, we showed that regenerating stem cells in the axolotl spinal cord revert to a molecular state resembling embryonic neuroepithelial cells and functionally acquire rapid proliferative divisions (Rodrigo Albors et al., 2015). Here, we refine the analysis of cell proliferation in space and time and identify a high-proliferation zone in the regenerating spinal cord that shifts posteriorly over time. By tracking sparsely-labeled cells, we also quantify cell influx into the regenerate. Taking a mathematical modeling approach, we integrate these quantitative datasets of cell proliferation, neural stem cell activation and cell influx, to predict regenerative tissue outgrowth. Our model shows that while cell influx and neural stem cell activation play a minor role, the acceleration of the cell cycle is the major driver of regenerative spinal cord outgrowth in axolotls.DOI: http://dx.doi.org/10.7554/eLife.20357.001

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“…Increased proliferation of SOX2 + cells upon spinal cord injury is a common feature among vertebrates (Becker and Becker, 2015). In zebrafish (Hui et al, 2010(Hui et al, , 2015, Xenopus (Gaete et al, 2012), mouse (Lacroix et al, 2014) and axolotl (this work, Rodrigo Albors et al, 2015;Holtzer, 1956) traumatic spinal cord injury triggers a long-range wave of increased cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls

Rost

Albors

Mazurov

et al. 2016

Preprint

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Axolotls are unique in their ability to regenerate the spinal cord. However, the mechanisms that underlie this phenomenon remain poorly understood. Previously, we showed that regenerating stem cells in the axolotl spinal cord revert to a molecular state resembling embryonic neuroepithelial cells and functionally acquire rapid proliferative divisions (Rodrigo Albors et al., 2015). Here, we refine the analysis of cell proliferation in space and time and identify a highproliferation zone in the regenerating spinal cord that shifts posteriorly over time. By tracking sparsely-labeled cells, we also quantify cell influx into the regenerate. Taking a mathematical modeling approach, we integrate these quantitative datasets of cell proliferation, neural stem cell activation and cell influx, to predict regenerative tissue outgrowth. Our model shows that while cell influx and neural stem cell activation play a minor role, the acceleration of the cell cycle is the major driver of regenerative spinal cord outgrowth in axolotls.

show abstract

Neuronal Regeneration from Ependymo-Radial Glial Cells: Cook, Little Pot, Cook!

Cited by 86 publications

References 141 publications

Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration

Distinct roles of neuroepithelial-like and radial glia-like progenitor cells in cerebellar regeneration

Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls

Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls

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