Neuronal regeneration in the cerebellum of adult teleost fish, Apteronotus leptorhynchus: guidance of migrating young cells by radial glia

Clint, Sorcha C.; Zupanc, Günther K.H.

doi:10.1016/s0165-3806(01)00193-6

Cited by 65 publications

(39 citation statements)

References 61 publications

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“…Intuitively, lifelong neurogenesis seems necessary for the maintenance of a stable ratio of central to peripheral units [Zupanc, 2001]. Adult-born neurons are also the substrate of regeneration of damaged neural tissue; adultborn neurons are recruited to the site of injury, where they mature and integrate into the local neural network [Zupanc and Ott, 1999;Clint and Zupanc, 2001]. As a considerable proportion of long-term-persisting adult-born neurons are found in the dorsolateral telencephalon [Zupanc et al, 2005;Hinsch and Zupanc, 2007], it is plausible that neurogenesis in the limbic forebrain comprises a neural substrate for behavioral plasticity also in fish, although the evidence for this is correlational rather than experimental [see the review by Sørensen et al, 2013].…”

Section: Neurogenesis In Fishmentioning

confidence: 99%

On the Role of Neurogenesis and Neural Plasticity in the Evolution of Animal Personalities and Stress Coping Styles

Øverli

Sørensen

2016

Brain Behav Evol

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Individual variation in how animals react to stress and environmental change has become a central topic in a wide range of biological disciplines, from evolutionary ecology to biomedicine. Such variation manifests phenotypically as correlated trait-clusters (referred to as coping styles, behavioral syndromes, shyness-boldness, or personality traits). Thresholds for switching from active coping (fight-flight) to inhibition and passive behavior when exposed to stress depend on experience and genetic factors. Comparative research has revealed a range of neuroendocrine-behavioral associations which are conserved throughout the vertebrate subphylum, including factors affecting perception, learning, and memory of stimuli and events. Here we review conserved aspects of the contribution of neurogenesis and other aspects of neural plasticity to stress coping. In teleost fish, brain cell proliferation and neurogenesis have received recent attention. This work reveals that brain cell proliferation and neurogenesis are associated with heritable variation in stress coping style, and they are also differentially affected by short- and long-term stress in a biphasic manner. Routine-dependent and inflexible behavior in proactive individuals is associated with limited neural plasticity. These evolutionarily conserved relationships hold the potential to illuminate the biological background for stress-related neurobiological disorders.

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Section: Neurogenesis In Fishmentioning

confidence: 99%

On the Role of Neurogenesis and Neural Plasticity in the Evolution of Animal Personalities and Stress Coping Styles

Øverli

Sørensen

2016

Brain Behav Evol

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“…The stab wound induces enhanced proliferation in both the constitutively active zones and in ectopic locations at the lesion site. There is a substantial increase of glial fibrillary acidic protein (GFAP)-positive radial fibres at the lesion site as well as the migration of newly produced cells from the proliferation zones (Clint & Zupanc 2001). At least some of the generated cells are differentiating into granule neurons that emit projections (Zupanc & Ott 1999).…”

Section: (D) Reptilesmentioning

confidence: 99%

Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain

Kaslin

Ganz

Brand

2007

Phil. Trans. R. Soc. B

319

302

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Post-embryonic neurogenesis is a fundamental feature of the vertebrate brain. However, the level of adult neurogenesis decreases significantly with phylogeny. In the first part of this review, a comparative analysis of adult neurogenesis and its putative roles in vertebrates are discussed. Adult neurogenesis in mammals is restricted to two telencephalic constitutively active zones. On the contrary, non-mammalian vertebrates display a considerable amount of adult neurogenesis in many brain regions. The phylogenetic differences in adult neurogenesis are poorly understood. However, a common feature of vertebrates (fish, amphibians and reptiles) that display a widespread adult neurogenesis is the substantial post-embryonic brain growth in contrast to birds and mammals. It is probable that the adult neurogenesis in fish, frogs and reptiles is related to the coordinated growth of sensory systems and corresponding sensory brain regions. Likewise, neurons are substantially added to the olfactory bulb in smell-oriented mammals in contrast to more visually oriented primates and songbirds, where much fewer neurons are added to the olfactory bulb. The second part of this review focuses on the differences in brain plasticity and regeneration in vertebrates. Interestingly, several recent studies show that neurogenesis is suppressed in the adult mammalian brain. In mammals, neurogenesis can be induced in the constitutively neurogenic brain regions as well as ectopically in response to injury, disease or experimental manipulations. Furthermore, multipotent progenitor cells can be isolated and differentiated in vitro from several otherwise silent regions of the mammalian brain. This indicates that the potential to recruit or generate neurons in non-neurogenic brain areas is not completely lost in mammals. The level of adult neurogenesis in vertebrates correlates with the capacity to regenerate injury, for example fish and amphibians exhibit the most widespread adult neurogenesis and also the greatest capacity to regenerate central nervous system injuries. Studying these phenomena in non-mammalian vertebrates may greatly increase our understanding of the mechanisms underlying regeneration and adult neurogenesis. Understanding mechanisms that regulate endogenous proliferation and neurogenic permissiveness in the adult brain is of great significance in therapeutical approaches for brain injury and disease.

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“…In the mullet, the midline glial septa found in several brain regions (the medullary raphe, midbrain tegmentum, cerebellum, torus longitudinalis) were Vim and/or GFAP immunoreactive. In teleosts, the GFAP-ir midline glial septum of the cerebellum has been involved in neuronal guidance during regeneration (Clint and Zupanc, 2001). The specialized midline glial systems found in the brain and/or spinal cord of developing mammals, birds, and zebrafish may provide guidance cues for developing commissural axons, including chemoattraction and chemorepulsion by either membrane-bound or diffusible molecules (Van Hartesveldt et al, 1986;Tessier-Lavigne et al, 1988;McKanna and Cohen, 1989;Mori et al, 1990;Yaginuma and Oppenheim, 1991;Silver et al, 1993;Cummings et al, 1997;Lustig et al, 2001).…”

Section: Glial Septa and Brain Subdivisionsmentioning

confidence: 99%

Development of vimentin and glial fibrillary acidic protein immunoreactivities in the brain of gray mullet (Chelon labrosus), an advanced teleost

Arochena

Anadón

Díaz-Regueira

2004

J of Comparative Neurology

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Previous studies in teleosts have revealed the presence of the intermediate filaments vimentin (Vim) and glial fibrillary acidic protein (GFAP) in glial cells of the spinal cord and/or some brain regions, but there is no comprehensive study of their distribution and developmental changes in fishes. Here, the distribution of Vim and GFAP immunoreactivities was studied in the brain of larvae, juveniles, and adults of an advanced teleost, the gray mullet (Chelon labrosus). A different sequence of appearance was observed for expression of these proteins: Vim levels decreased with age, whereas GFAP increased. In general, both immunoreactivities were expressed early in perikarya and endfeet of ependymocytes (tanycytes), whereas expression in radial processes appeared later. In large larvae, the similar expression patterns of Vim and GFAP suggest that some of these glial cells contain both proteins. Subependymal radial glia cells were observed mainly in the optic tectum, exhibiting Vim and GFAP immunoreactivity. The only immunoreactive cells with astrocyte-like morphology were observed in the optic chiasm of the adult, and they were positive for both GFAP and Vim. The perivascular processes of glial cells showed a different distribution of Vim and GFAP during development and had a caudorostral sequence of appearance of immunoreactivities similar to that observed for ependymal and radial glia cells. Several circumventricular organs (the organon vasculosum hypothalami, saccus vasculosus, and area postrema) exhibited highly specialized Vim- and/or GFAP-expressing glial cells. The glial cells of the midline septa of several brain regions were also Vim and/or GFAP immunoreactive. In the adult brain, tanycytes retain Vim expression in several brain regions. As in other vertebrates, the regions with Vim-immunoreactive ventricular and midline glia may represent areas with the capability of plasticity and regeneration in adult brain.

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Neuronal regeneration in the cerebellum of adult teleost fish, Apteronotus leptorhynchus: guidance of migrating young cells by radial glia

Cited by 65 publications

References 61 publications

On the Role of Neurogenesis and Neural Plasticity in the Evolution of Animal Personalities and Stress Coping Styles

On the Role of Neurogenesis and Neural Plasticity in the Evolution of Animal Personalities and Stress Coping Styles

Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain

Development of vimentin and glial fibrillary acidic protein immunoreactivities in the brain of gray mullet (Chelon labrosus), an advanced teleost

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