2024
DOI: 10.3389/fgene.2024.1345410
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Neuronal-specific methylome and hydroxymethylome analysis reveal significant loci associated with alcohol use disorder

Diego E. Andrade-Brito,
Diana L. Núñez-Ríos,
José Jaime Martínez-Magaña
et al.

Abstract: Background: Alcohol use disorder (AUD) is a complex condition associated with adverse health consequences that affect millions of individuals worldwide. Epigenetic modifications, including DNA methylation (5 mC), have been associated with AUD and other alcohol-related traits. Epigenome-wide association studies (EWAS) have identified differentially methylated genes associated with AUD in human peripheral and brain tissue. More recently, epigenetic studies of AUD have also evaluated DNA hydroxymethylation (5 hmC… Show more

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