2002
DOI: 10.1046/j.0022-3042.2001.00749.x
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Neuronal storage of histamine in the brain and tele‐methylimidazoleacetic acid excretion in portocaval shunted rats

Abstract: Rats with portocaval anastomosis (PCA), an animal model of hepatic encephalopathy (HE), have very high brain histamine concentrations. Our previous studies based on a biochemical approach indicated histamine accumulation in the neuronal compartment. In this study, immunohistochemical evidence is presented which further supports the amine localization in histaminergic neurons. These neurons become pathological in appearance with cisternae frequently seen along histaminergic fibres in many brain areas, including… Show more

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Cited by 19 publications
(12 citation statements)
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“…A concomitant increase in densities (B max ) of H 1 R in the frontal cortex has also been reported in patients with hepatic encephalopathy (Lozeva et al, 2001). Similar increases in brain histamine have been reported in portocavally shunted rats (Fogel et al, 2002). Taken together, changes in brain histamine, H 1 R, and H 3 R are found in patients with hepatic failure, and these changes coincide with sleep disturbances, abnormal circadian rhythm, and other neuropsychiatric disturbances.…”
Section: Are the Models Relevant For Humansupporting
confidence: 55%
“…A concomitant increase in densities (B max ) of H 1 R in the frontal cortex has also been reported in patients with hepatic encephalopathy (Lozeva et al, 2001). Similar increases in brain histamine have been reported in portocavally shunted rats (Fogel et al, 2002). Taken together, changes in brain histamine, H 1 R, and H 3 R are found in patients with hepatic failure, and these changes coincide with sleep disturbances, abnormal circadian rhythm, and other neuropsychiatric disturbances.…”
Section: Are the Models Relevant For Humansupporting
confidence: 55%
“…In addition to its function in immune and inflammation responses [182,183], histamine is considered to be a modulator of gastric acid secretion in the stomach [184,185], a neurotransmitter involved in memory, appetite and circadian rhythms regulation [186][187][188], and a modulator of cell growth [189][190][191]. Histamine is also essential in angiogenesis, cellular differentiation of mast cells, and bone loss osteoporosis [186][187][188][189][190][191][192]. Therefore, HDC is a potential target for therapeutic intervention in many inflammatory diseases, some neurological and neuroendocrine disorders, osteoporosis and even several types of neoplasias [193][194][195][196].…”
Section: Ornithine Decarboxylasementioning
confidence: 99%
“…(5)(6)(7) Histamine has also been described as a modulator of cell growth. (8)(9)(10) Thus, impairment of histamine metabolism is related to highly prevalent pathologies such as many inflammatory responses, peptic ulcer, schizophrenia and tumour progression, among others.…”
Section: Introductionmentioning
confidence: 99%