NEURONAL SUBSTRATES OF COMPLEX BEHAVIORS IN <i>C. ELEGANS</i>

Bono, Mario de; Maricq, Andres V.

doi:10.1146/annurev.neuro.27.070203.144259

Cited by 369 publications

(338 citation statements)

References 237 publications

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“…temperature, representing a popular genetic model organism for the study of sensory perception (de Bono and Maricq, 2005). Despite the lack of eyes, C. elegans also responds to light (Edwards et al, 2008;Ward et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

The C. elegans Taste Receptor Homolog LITE-1 Is a Photoreceptor

Gong¹,

Yuan²,

Ward³

et al. 2017

Cell

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SummaryMany animal tissues/cells are photosensitive, yet only two types of photoreceptors (opsins and cryptochromes) have been discovered in metazoans. The question arises as to whether unknown types of photoreceptors exist in the animal kingdom. LITE-1, a seven-transmembrane gustatory receptor (GR) homolog, mediates UV light-induced avoidance behavior in C. elegans. However, whether LITE-1 functions as a chemoreceptor or photoreceptor has not been determined. Here, we show that LITE-1 directly absorbs both UVA and UVB light with an extinction coefficient 10-100 times that of opsins and cryptochromes, indicating that LITE-1 is highly efficient in capturing photons. Unlike typical photoreceptor proteins employing a prosthetic chromophore to capture photons, LITE-1 strictly depends on its protein conformation for photon absorption. We further identified two tryptophan residues critical for LITE-1 function. Interestingly, unlike GPCRs, LITE-1 adopts a reversed membrane topology. Thus, LITE-1, a taste receptor homolog, represents a distinct type of photoreceptor in the animal kingdom.

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Section: Introductionmentioning

confidence: 99%

The C. elegans Taste Receptor Homolog LITE-1 Is a Photoreceptor

Gong¹,

Yuan²,

Ward³

et al. 2017

Cell

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“…Nevertheless, no similar endogenous lifespan predictors have been identified in worms. Locomotion behavior represents one of the most prominent behaviors in C. elegans [4]. It is known that old worms develop motor deficits and are less active than young worms [5,9,13,14,16,18].…”

Section: Introductionmentioning

confidence: 99%

Identification by machine vision of the rate of motor activity decline as a lifespan predictor in C. elegans

Hsu

Feng

Hsieh

et al. 2009

Neurobiology of Aging

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One challenge in aging research concerns identifying physiological parameters or biomarkers that can reflect the physical health of an animal and predict its lifespan. In C. elegans, a model organism widely used in aging research, motor deficits develop in old worms. Here we employed machine vision to quantify worm locomotion behavior throughout lifespan. We confirm that aging worms undergo a progressive decline in motor activity, beginning in early life. Importantly, the rate of motor activity decline rather than the absolute motor activity in the early-to-mid life of individual worms in an isogenic population inversely correlates with their lifespan, and thus may serve as a lifespan predictor. Long-lived mutant strains with deficits in insulin/IGF-1 signaling or food intake display a reduction in the rate of motor activity decline, suggesting that this parameter might also be used for across-strain comparison of healthspan. Our work identifies an endogenous physiological parameter for lifespan prediction and healthspan comparison.

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“…For the sake of brevity, I will concentrate solely on these behaviors in the hermaphrodite. I refer the reader to several excellent publications and references therein addressing C. elegans male chemosensory behaviors [1][2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Generation and modulation of chemosensory behaviors in C. elegans

Sengupta

2007

Pflugers Arch - Eur J Physiol

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C. elegans recognizes and discriminates among hundreds of chemical cues using a relatively compact chemosensory nervous system. Chemosensory behaviors are also modulated by prior experience and contextual cues. Because of the facile genetics and genomics possible in this organism, C. elegans provides an excellent system in which to explore the generation of chemosensory behaviors from the level of a single gene to the motor output. This review summarizes the current knowledge on the molecular and neuronal substrates of chemosensory behaviors and chemosensory behavioral plasticity in C. elegans.

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NEURONAL SUBSTRATES OF COMPLEX BEHAVIORS IN C. ELEGANS

Cited by 369 publications

References 237 publications

The C. elegans Taste Receptor Homolog LITE-1 Is a Photoreceptor

The C. elegans Taste Receptor Homolog LITE-1 Is a Photoreceptor

Identification by machine vision of the rate of motor activity decline as a lifespan predictor in C. elegans

Generation and modulation of chemosensory behaviors in C. elegans

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