Neuronal tangential migration from Nkx2.1-positive hypothalamus

Murcia-Ramón, Raquel; Juárez-Leal, Iris; Andreu-Cervera, Abraham; Almagro-García, Francisca; Echevarrı́a, Diego; Puelles, Eduardo

doi:10.1007/s00429-020-02163-x

Cited by 9 publications

(10 citation statements)

References 42 publications

(36 reference statements)

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“…Present data demonstrating their origin at the RM area accordingly falsate this conclusion. In recent years, various hypothalamic studies have highlighted a diversity of tangential migrations within, from or into the basal hypothalamus ( Zhao et al, 2008 ; Morales-Delgado et al, 2011 , 2014 ; Skidmore et al, 2008 , 2012 ; Puelles et al, 2012 ; Díaz et al, 2015 ; Alvarez-Bolado, 2019 ; Murcia-Ramón et al, 2020 ), so that this possibility needs to be considered in neurogenetic studies.…”

Section: Discussionmentioning

confidence: 99%

Tangential Intrahypothalamic Migration of the Mouse Ventral Premamillary Nucleus and Fgf8 Signaling

López-González

Alonso

Garcı́a-Calero

et al. 2021

Front. Cell Dev. Biol.

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The tuberal hypothalamic ventral premamillary nucleus (VPM) described in mammals links olfactory and metabolic cues with mating behavior and is involved in the onset of puberty. We offer here descriptive and experimental evidence on a migratory phase in the development of this structure in mice at E12.5–E13.5. Its cells originate at the retromamillary area (RM) and then migrate tangentially rostralward, eschewing the mamillary body, and crossing the molecularly distinct perimamillary band, until they reach a definitive relatively superficial ventral tuberal location. Corroborating recent transcriptomic studies reporting a variety of adult glutamatergic cell types in the VPM, and different projections in the adult, we found that part of this population heterogeneity emerges already early in development, during tangential migration, in the form of differential gene expression properties of at least 2–3 mixed populations possibly derived from subtly different parts of the RM. These partly distribute differentially in the core and shell parts of the final VPM. Since there is a neighboring acroterminal source of Fgf8, and Fgfr2 is expressed at the early RM, we evaluated a possible influence of Fgf8 signal on VPM development using hypomorphic Fgf8neo/null embryos. These results suggested a trophic role of Fgf8 on RM and all cells migrating tangentially out of this area (VPM and the subthalamic nucleus), leading in hypomorphs to reduced cellularity after E15.5 without alteration of the migrations proper.

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Section: Discussionmentioning

confidence: 99%

Tangential Intrahypothalamic Migration of the Mouse Ventral Premamillary Nucleus and Fgf8 Signaling

López-González

Alonso

Garcı́a-Calero

et al. 2021

Front. Cell Dev. Biol.

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“…For IHC, it was performed as previously described ( Murcia-Ramón et al, 2020 ). The primary antibodies used were: αTH (1:1,000; 208020234/Inst.…”

Section: Methodsmentioning

confidence: 99%

Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus

Moreno-Cerdá

Andreu-Cervera

Murcia-Ramón

et al. 2021

Front. Cell Dev. Biol.

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Wnt1 is one of the morphogenes that controls the specification and differentiation of neuronal populations in the developing central nervous system. The habenula is a diencephalic neuronal complex located in the most dorsal aspect of the thalamic prosomere. This diencephalic neuronal population is involved in the limbic system and its malfunction is related with several psychiatric disorders. Our aim is to elucidate the Wnt1 role in the habenula and its main efferent tract, the fasciculus retroflexus, development. In order to achieve these objectives, we analyzed these structures development in a Wnt1 lack of function mouse model. The habenula was generated in our model, but it presented an enlarged volume. This alteration was due to an increment in habenular neuroblasts proliferation rate. The fasciculus retroflexus also presented a wider and disorganized distribution and a disturbed final trajectory toward its target. The mid-hindbrain territories that the tract must cross were miss-differentiated in our model. The specification of the habenula is Wnt1 independent. Nevertheless, it controls its precursors proliferation rate. Wnt1 expressed in the isthmic organizer is vital to induce the midbrain and rostral hindbrain territories. The alteration of these areas is responsible for the fasciculus retroflexus axons misroute.

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“…The hypothalamic basal plate has been defined as a Shh + / Nkx2-1 + territory ( Shimamura et al, 1997 ; Puelles et al, 2012 ). Nkx2-1 + progenitors can be found in the terminal and peduncular hypothalamus, while Nkx2-1 + neurons contribute to adult arcuate nucleus, ventromedial and dorsomedial nuclei, and the mammillary nucleus, as demonstrated in both mice and rats ( Nakamura et al, 2001 : Puelles et al, 2012 ; Puelles and Rubenstein, 2015 ; Alvarez-Bolado, 2019 ; Murcia-Ramón et al, 2020 ; Barbier and Risold, 2021 ). The Nkx2-1 -null mice have an abnormal hypothalamic anatomy, with many hypothalamic nuclei missing or underdeveloped ( Kimura et al, 1996 ).…”

Section: Transcription Factors In the Developing And Adult Subthalami...mentioning

confidence: 99%

Transcriptional Profile of the Developing Subthalamic Nucleus

Bokulić

Medenica²,

Sedmak³

2022

eNeuro

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The subthalamic nucleus (STN) is a small, excitatory nucleus that regulates the output of basal ganglia motor circuits. The functions of the STN and its role in the pathophysiology of Parkinson’s disease are now well established. However, some basic characteristics like the developmental origin and molecular phenotype of neuronal subpopulations are still being debated. The classical model of forebrain development attributed the origin of STN within the diencephalon. Recent studies of gene expression patterns exposed shortcomings of the classical model. To accommodate these findings, the prosomeric model was developed. In this concept, STN develops within the hypothalamic primordium, which is no longer a part of the diencephalic primordium. This concept is further supported by the expression patterns of many transcription factors. It is interesting to note that many transcription factors involved in the development of the STN are also involved in the pathogenesis of neurodevelopmental disorders. Thus, the study of neurodevelopmental disorders could provide us with valuable information on the roles of these transcription factors in the development and maintenance of STN phenotype. In this review, we summarize historical theories about the developmental origin of the STN and interpret the gene expression data within the prosomeric conceptual framework. Finally, we discuss the importance of neurodevelopmental disorders for the development of the STN and its potential role in the pathophysiology of neurodevelopmental disorders.

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Neuronal tangential migration from Nkx2.1-positive hypothalamus

Cited by 9 publications

References 42 publications

Tangential Intrahypothalamic Migration of the Mouse Ventral Premamillary Nucleus and Fgf8 Signaling

Tangential Intrahypothalamic Migration of the Mouse Ventral Premamillary Nucleus and Fgf8 Signaling

Wnt1 Role in the Development of the Habenula and the Fasciculus Retroflexus

Transcriptional Profile of the Developing Subthalamic Nucleus

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