2022
DOI: 10.1101/2022.11.03.515099
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Neurons alter endoplasmic reticulum exit sites to accommodate dendritic arbor size

Abstract: Nervous systems exhibit dramatic diversity in cell morphology and size. How neurons regulate their biosynthetic and secretory machinery to support different cell sizes is not well understood. Endoplasmic reticulum exit sites (ERESs) are essential for maintaining secretory flux, and are required for normal dendrite development.1However, it is unknown how neurons of different size regulate the number of secretory structures to accommodate morphogenesis. InC. elegans, we find that ERES number is strongly correlat… Show more

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