Neurons in the Pigeon Nidopallium Caudolaterale Display Value-Related Activity

Dykes, Madeline; Klarer, Aylin; Porter, Blake; Rose, Jonas; Colombo, Michael

doi:10.1038/s41598-018-23694-8

Cited by 25 publications

(23 citation statements)

References 24 publications

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“…In mammals, it appears that the brain makes simple choices by assigning value to the options under consideration, and the pallial amygdala-to-OFC projection is essential for this and more important than the reciprocal OFC-to-amygdala projection (Jenison, 2014). In birds, neurons of the caudolateral nidopallium display value-related activity (Dykes et al, 2018). In addition, the caudal nidopallium plays a role in decision-making, and at least in crows is involved in complex tasks using flexible working memory (Güntürkün, 2005; Güntürkün and Bugnyar, 2016; Hartmann et al, 2018).…”

Section: Brain Network Involved In Sociality In Non-mammalsmentioning

confidence: 99%

Evolution of Pallial Areas and Networks Involved in Sociality: Comparison Between Mammals and Sauropsids

2019

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Birds are extremely interesting animals for studying the neurobiological basis of cognition and its evolution. They include species that are highly social and show high cognitive capabilities. Moreover, birds rely more on visual and auditory cues than on olfaction for social behavior and cognition, just like primates. In primates, there are two major brain networks associated to sociality: (1) one related to perception and decision-making, involving the pallial amygdala (with the basolateral complex as a major component), the temporal and temporoparietal neocortex, and the orbitofrontal cortex; (2) another one related to affiliation, including the medial extended amygdala, the ventromedial prefrontal and anterior cingulate cortices, the ventromedial striatum (largely nucleus accumbens), and the ventromedial hypothalamus. In this account, we used an evolutionary developmental neurobiology approach, in combination with published comparative connectivity and functional data, to identify areas and functional networks in the sauropsidian brain comparable to those of mammals that are related to decision-making and affiliation. Both in mammals and sauropsids, there is an important interaction between these networks by way of cross projections between areas of both systems.

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Section: Brain Network Involved In Sociality In Non-mammalsmentioning

confidence: 99%

Evolution of Pallial Areas and Networks Involved in Sociality: Comparison Between Mammals and Sauropsids

2019

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“…This might also be one of the key explanations for the impairment in extinction acquisition observed in our study. To date, several studies could reveal a central role of the NCL in encoding reward amount and subjective reward value (Kalenscher et al, 2005; Koenen et al, 2013; Dykes et al, 2018). It is therefore possible that NCL efferents have a strong impact on reward value coding of StM neurons (Yanagihara et al, 2001), which also explains the similarity of the results from our study with that obtained from NCL.…”

Section: Discussionmentioning

confidence: 99%

Blocking NMDA-Receptors in the Pigeon’s Medial Striatum Impairs Extinction Acquisition and Induces a Motoric Disinhibition in an Appetitive Classical Conditioning Paradigm

Gao

Pusch

Güntürkün

2019

Front. Behav. Neurosci.

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The medial striatum of birds resembles the mammalian dorsal striatum, which plays a key role in the extinction of learned behavior. To uncover the variant and invariant neural properties of extinction learning across species, we use pigeons as an animal model in an appetitive extinction paradigm. Here, we targeted a medial sub-region of the pigeon’s striatum that receives executive, visual and motor pallial projections. By locally antagonizing the N -methyl-D-aspartate (NMDA) receptors through 2-Amino-5-phosphonovalerianacid (APV) during extinction, we observed an unspecific disinhibition effect, namely an increase in conditioned pecking to a rewarded control stimulus. In addition, blocking the NMDA receptors substantially deteriorated the extinction acquisition, implying that the pigeons still responded vigorously to the CS- even without food reward during extinction. After correcting for the unspecific effect of APV, the impaired extinction acquisition remained significant, which leads to the assumption that the delayed extinction effect is possibly caused by deficits in the updating of value coding of altered reward contingencies. Also, the APV-induced disinhibition seems to result from local hyperactivity that primarily drives actions towards cues of high appetitive value. The overall correspondence of our results with those from mammals suggests common neural substrates of extinction and highlights the shared functionality of the avian and mammalian dorsal striatum despite 300 million years of independent evolution.

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“…The apparatus and the methods used were similar to that used by Dykes et al . 25 . The pigeons were trained and tested in standard operant chambers measuring 35 cm (length) x 43 cm (width) x 39 cm (height).…”

Section: Methodsmentioning

confidence: 99%

“…Data analysis was similar to that used in Dykes et al . 25 The 300 ms sample period (Sample), the 2 sec Pre-Effort period (Pre-Effort), the 300 ms effort period (Effort), the 2 sec Post-Effort period (Post-Effort) and the 2 sec reward period (Reward) were all subject to analysis. With respect to the Sample period, unlike studies with primates where one can monitor the exact position of the eyes, it is difficult in pigeons to monitor when they are looking at the visual stimulus.…”

Section: Methodsmentioning

confidence: 99%

Neurons in the pigeon nidopallium caudolaterale, but not the corticoidea dorsolateralis, display value and effort discounting activity

Dykes

Porter

Colombo

2019

Sci Rep

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We recorded from single neurons in two areas of the pigeon brain while birds were required to peck a stimulus indicating either a high effort task or a low effort task would follow. Upon completion of the task the birds received the same reward. We found that activity in the nidopallium caudolaterale, an area equivalent to the mammalian prefrontal cortex, was modulated by the value of the reward that would be received based on how much effort was required to obtain it. Value coding was most prominent during the presentation of the stimulus indicating a high or low effort task, and in the delay period immediately prior to carrying out the effort task. In contrast, activity in the corticoidea dorsolateralis was not modulated by value, however, population firing patterns suggest that it may be involved in associating actions with outcomes. Our findings support the view that activity in the nidopallium caudolaterale reflects value of reward as a function of effort discounting and as such may serve functions similar to the mammalian anterior cingulate cortex.

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Neurons in the Pigeon Nidopallium Caudolaterale Display Value-Related Activity

Cited by 25 publications

References 24 publications

Evolution of Pallial Areas and Networks Involved in Sociality: Comparison Between Mammals and Sauropsids

Evolution of Pallial Areas and Networks Involved in Sociality: Comparison Between Mammals and Sauropsids

Blocking NMDA-Receptors in the Pigeon’s Medial Striatum Impairs Extinction Acquisition and Induces a Motoric Disinhibition in an Appetitive Classical Conditioning Paradigm

Neurons in the pigeon nidopallium caudolaterale, but not the corticoidea dorsolateralis, display value and effort discounting activity

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