Neuronuclear Assessment of Patients With Epilepsy

Seizures and Amyloid-β induce similar changes in neuronal network metabolic parameters in mouse hippocampal slices

“…Major risk factors for acquired epilepsy (traumatic brain injury, stroke, viral infection, status epilepticus (Waldbaum and Patel, 2010;Pitkanen et al, 2015) all share hypometabolic brain state as the common outcome; in turn, epileptic patients' also exhibit brain hypometabolism, seen as reduced glucose utilization in FDG-PET analysis (Goffin et al, 2008). To examine whether epileptic activity impairs PeerJ Preprints | https://doi.org/10.7287/peerj.preprints.2521v1 | CC BY 4.0 Open Access |…”

“…In addition, we found that in both cases, subsequent addition of pyruvate, the principal mitochondrial fuel possessing multiple neuroprotective properties, completely normalised the disputed energy state. Our data supports the hypothesis that energy metabolism deficiency underlies the initiation of neurodegenerative diseases.Major risk factors for acquired epilepsy (traumatic brain injury, stroke, viral infection, status epilepticus (Waldbaum and Patel, 2010;Pitkanen et al, 2015) all share hypometabolic brain state as the common outcome; in turn, epileptic patients' also exhibit brain hypometabolism, seen as reduced glucose utilization in FDG-PET analysis (Goffin et al, 2008). To examine whether epileptic activity impairs PeerJ Preprints | https://doi.org/10.7287/peerj.preprints.2521v1 | CC BY 4.0 Open Access |…”

“…Major risk factors for acquired epilepsy (traumatic brain injury, stroke, viral infection, status epilepticus (Waldbaum and Patel, 2010;Pitkanen et al, 2015) all share hypometabolic brain state as the common outcome; in turn, epileptic patients' also exhibit brain hypometabolism, seen as reduced glucose utilization in FDG-PET analysis (Goffin et al, 2008). To examine whether epileptic activity impairs metabolism and induces changes in network function, we measured synaptic stimulation-induced (10Hz, 10s) metabolic (oxygen, NAD(P)H, FAD and extracellular glucose) parameter transients in hippocampal slices before and after a few seizures (which resulted in massive glucose/oxygen consumption and oxidative stress) induced by 1s, 100Hz synaptic stimulation in the presence of 4-AP.…”

Evaluation of Focal Cortical Dysplasia and Mixed Neuronal and Glial Tumors in Pediatric Epilepsy Patients Using18F-FDG and11C-Methionine PET

“…Eleven patients had FCD, 8 patients had a DNT, and 11 patients had a ganglioglioma. 18 F-FDG and 11 C-methinine PET scans were obtained from 25 patients and 15 patients, respectively. Visual grading analysis and quantitative assessment of 18 F-FDG and 11 C-methionine PET, represented as a lesion-to-gray matter ratio (LGR), were performed.…”

A Functional Role for Microglia in Epilepsy

“…While we interpreted this result with caution, we concluded that activated microglia may contribute a small, but potentially important, proportion of the metabolic signal. It is possible then, that changes in glial function could be a component of metabolic abnormalities which are observed in epileptic patients (Lamusuo et al, 2001, Goffin et al, 2008b and rodent seizure models (Kornblum et al, 2000, Mirrione et al, 2006, Mirrione et al, 2007, Goffin et al, 2009. Therefore, in the next section we will discuss how neuroimaging approaches using specific radiotracers which target microglia, can facilitate our understanding of the pathology underlying epileptogenesis.…”