1991
DOI: 10.1007/bf00308809
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Neuropathological stageing of Alzheimer-related changes

Abstract: Eighty-three brains obtained at autopsy from nondemented and demented individuals were examined for extracellular amyloid deposits and intraneuronal neurofibrillary changes. The distribution pattern and packing density of amyloid deposits turned out to be of limited significance for differentiation of neuropathological stages. Neurofibrillary changes occurred in the form of neuritic plaques, neurofibrillary tangles and neuropil threads. The distribution of neuritic plaques varied widely not only within archite… Show more

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Cited by 13,952 publications
(12,572 citation statements)
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References 47 publications
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“…A neuropathological diagnosis of AD was confirmed according to the criteria of Braak. 25 Blocks of AD or control tissue were fixed in 10% neutral buffered formalin for 48 h. After fixation, the brain tissue was dehydrated and embedded in paraffin. Immunohistochemistry was performed using a Vectastain avidin-biotin complex (ABC) elite kit (Vector, Burlingame, CA, USA) as described previously.…”
Section: Discussionmentioning
confidence: 99%
“…A neuropathological diagnosis of AD was confirmed according to the criteria of Braak. 25 Blocks of AD or control tissue were fixed in 10% neutral buffered formalin for 48 h. After fixation, the brain tissue was dehydrated and embedded in paraffin. Immunohistochemistry was performed using a Vectastain avidin-biotin complex (ABC) elite kit (Vector, Burlingame, CA, USA) as described previously.…”
Section: Discussionmentioning
confidence: 99%
“…Each of the specimens was cut into 8‐ to 15‐mm sections except for the brainstem, which was cut into 5‐mm sections, and the microinfarcts and bleeding were carefully evaluated in each section. A neuropathologic diagnosis of AD was made following the National Institute on Aging―Reagan Institute criteria21; the frequencies of neuritic plaques and neurofibrillary tangles were evaluated using the Consortium to Establish a Registry for Alzheimer's Disease criteria22 and Braak stage 23. Definite VaD cases were confirmed with causative stroke or cerebrovascular change and no neuropathologic evidence of other forms of dementia.…”
Section: Methodsmentioning
confidence: 99%
“…Neuropathologic diagnosis was made using previously published neuropathologic criteria, including Braak stages,18, 19 Consortium to Establish a Registry for Alzheimer's Disease scores,19, 20 Thal A β phases,19, 21 LBD pathologic criteria,11 and FTLD classification22 by neuropathologists who were blinded to the 123 I‐FP‐CIT SPECT findings.…”
Section: Methodsmentioning
confidence: 99%