Neuropathology of feral conures with bromethalin toxicosis

Abstract

Bromethalin is a widely used neurotoxic rodenticide sometimes affecting nontarget wildlife. However, the effects of bromethalin on avian species are largely unknown. Here, we report the neuropathology of 14 feral conures ( Psittacara sp.) with bromethalin toxicosis. Clinically, all birds presented with different degrees of paraparesis that sometimes progressed to dysphagia, ataxia, and tetraparesis. Histologically, there was astrogliosis, pallor, and vacuolation of white matter in the brain. This was usually more prominent in the medial longitudinal fasciculus, pons, optic tectum, cerebellar peduncle, and ventral funiculus. In most affected areas, there was loss of oligodendrocytes, and axons had extensive myelin loss or marked intramyelinic edema with splitting of myelin sheaths at the intraperiod line. Conures with bromethalin toxicosis had neuropathological changes similar to those of mammals exposed to bromethalin but with a characteristic distribution, probably related to higher susceptibility to cytotoxic edema in certain regions of the avian brain.

Experimental infection of domestic turkeys with lymphoproliferative disease virus of North American origin

“…Select tissues were subjected to CD3 immunohistochemical (IHC) labeling (1:1000, A05452; Dako, Carpinteria, CA) based on a previously published protocol. 34 Domestic dog lymph node was utilized as a positive control tissue and tissues without lymphocytic infiltration from the examined individual served as internal negative control tissues.…”