Neuropathology of the area postrema in sudden intrauterine and infant death syndromes related to tobacco smoke exposure

Lavezzi, Anna Maria; Mecchia, Donatella; Matturri, Luigi

doi:10.1016/j.autneu.2011.09.001

Cited by 26 publications

(20 citation statements)

References 34 publications

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“…As we did in our previous studies (Lavezzi et al, 2005, 2007, 2010, 2012a,b), we ascribe once again the neuropathological findings of this study to smoke absorption in fetal life. Prenatal chronic nicotine exposure primarily alters the development of fetal cholinergic and other neurotransmitter systems, so potentially affecting brainstem centers critical to cardiorespiratory and, more generally, all the autonomic functions control (Duncan et al, 2009).…”

Section: Discussionsupporting

confidence: 87%

“…The conclusion of this work is that considerable remodeling takes place in the MSO of sudden death victims, in addition to neurological alteration of brainstem and cerebellum previously highlighted by us (Matturri et al, 2002; Lavezzi et al, 2004, 2010, 2012a,b; Matturri and Lavezzi, 2007; Lavezzi and Matturri, 2008a). This leads to attribute to the MSO more important functions than those well-known related to hearing.…”

Section: Discussionsupporting

confidence: 57%

“…In the course of our neuropathologic investigations on victims of sudden intrauterine unexplained death syndrome (SIUDS) and sudden infant death syndrome (SIDS), we have highlighted specific abnormalities of nuclei and/or structures mediating vital functions, mainly located in the brainstem (Matturri et al, 2002; Lavezzi et al, 2004, 2010, 2012a,b; Matturri and Lavezzi, 2007; Lavezzi and Matturri, 2008a). These neurodevelopmental defects could play a key role in the pathogenetic mechanism of sudden and unexplained perinatal death.…”

Section: Introductionmentioning

confidence: 99%

“…In particular we have shown in these pathologies alterations of the facial/parafacial complex (F/PFc) and of the adjacent retrotrapezoid nucleus (RTN) (Lavezzi and Matturri, 2008b; Lavezzi et al, 2012a,b). …”

Section: Introductionmentioning

confidence: 99%

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Neuroanatomical dysmorphology of the medial superior olivary nucleus in sudden fetal and infant death

Lavezzi¹,

Matturri²

2012

Front. Hum. Neurosci.

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This study expands our understanding of the organization of the human caudal pons, providing a morphologic characterization of the medial superior olivary nucleus (MSO), component of the superior olivary complex (SOC) that plays an important role in the processing of acoustic information. We examined victims of sudden unexplained fetal and infant death and controls (n = 75), from 25 gestational weeks to 8 months of postnatal age, by complete autopsy and in-depth autonomic nervous system histological examination, particularly of the MSO nucleus, the focus of this study. Peculiar cytoarchitectural features of the MSO nucleus were found in sudden death cases, such as hypoplasia/agenesis and immature hypercellularity, frequently related to dysgenesis of contiguous structures involved in respiratory rhythm-generating circuit, in particular to hypoplasia of the retrotrapezoid and the facial nuclei. We propose the involvement of this nucleus in more important functions than those related to hearing, as breathing and, more extensively, all the vital activities. Besides, we highlight the fundamental role of the maternal smoking in pregnancy as etiological factor in the dysmorphic neuroanatomical development of the MSO nucleus.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neuroanatomical dysmorphology of the medial superior olivary nucleus in sudden fetal and infant death

Lavezzi¹,

Matturri²

2012

Front. Hum. Neurosci.

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“…html), even in a specific study focused on this structure. 10 The AP is a medullary formation devoid of the blood-brain barrier and, as such, enables blood-borne substances to arrive directly in the brain. 3,4 However, the AP neurons function as chemosensors, preventing the transit of harmful agents.…”

Section: Discussionmentioning

confidence: 99%

Sudden Infant Death With Area Postrema Lesion Likely Due to Wrong Use of Insecticide

et al. 2015

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We report a noteworthy case of a 7-month-old infant who suddenly and abstract\ud unexpectedly died during her sleep. After a complete postmortem examination,\ud review of the clinical history, and detailed death scene investigation, the death\ud remained unexplained, leading to a diagnosis of sudden infant death syndrome.\ud However, an extensive review of the brainstem neuropathology revealed a severe\ud alteration in the area postrema (a highly vascular structure lying at the base of\ud the fourth ventricle outside of the blood-brain barrier). The alteration was\ud likely due to massive and repeated to a common household insecticide in the last\ud few weeks of life. These results provide an explanation for this sudden infant\ud death, allowing a differential diagnosis from sudden infant death syndrome

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How Pathophysiology Explains Risk and Protective Factors

Horne

2020

Infant Safe Sleep

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Neuropathology of the area postrema in sudden intrauterine and infant death syndromes related to tobacco smoke exposure

Cited by 26 publications

References 34 publications

Neuroanatomical dysmorphology of the medial superior olivary nucleus in sudden fetal and infant death

Neuroanatomical dysmorphology of the medial superior olivary nucleus in sudden fetal and infant death

Sudden Infant Death With Area Postrema Lesion Likely Due to Wrong Use of Insecticide

How Pathophysiology Explains Risk and Protective Factors

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