Neuropeptidases in Psychiatric Disorders

Nani, João V.; Almeida, Priscila G. C.; Hayashi, Mirian A. F.

doi:10.1016/b978-0-12-819641-0.00091-8

Cited by 2 publications

(2 citation statements)

References 103 publications

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“…The specific relationship of NPS with a selected group of disorganization symptoms (excitement, hostility) makes it possible to conduct a more targeted anti-psychotic therapy. The results encourage further research on the relationship between NPS and the development of schizophrenia itself, as well as its treatment in general [ 61 ]. However, the study had some important limitations (small groups, males only, episodic schizophrenia sub-type only, and mixed rehabilitation/pharmacological therapy), so the verification of all hypotheses requires extending the current study.…”

Section: Discussionmentioning

confidence: 74%

Relationship of Neuropeptide S with Clinical and Metabolic Parameters of Patients during Rehabilitation Therapy for Schizophrenia

Markiewicz-Gospodarek

Dobrowolska

Maciejewski

et al. 2022

Brain Sciences

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Neuropeptide S (NPS) is a factor associated with the central regulation of body weight, stress, anxiety, learning, memory consolidation, wakefulness–sleep cycle, and anti-inflammatory and neuroplastic effects. Its stress-reducing, anti-anxiety, arousal without anxiety, and pro-cognitive effects represent an interesting option for the treatment of neuropsychiatric disorders. The purpose of the study was to examine the potential associations of NPS levels in the blood with clinical and metabolic parameters during the rehabilitation therapy of patients with schizophrenia. Thirty-three male subjects diagnosed with schizophrenia were randomly divided into two groups. The rehabilitation group (REH, N16) consisted of patients who were subjected to structured, 3-month intensive rehabilitation therapy, and the control group (CON, N17) consisted of patients who were subjected to a standard support mechanism. Both groups continued their pharmacological treatment as usual. The NPS concentration, as well as clinical and metabolic parameters, were compared in both groups. Additionally, a group of healthy (H) males (N15) was tested for NPS reference scores. To look for the specificity and selectivity of the NPS relationship with clinical results, various factor models of the positive and negative syndrome scale (PANSS) were analyzed, including the original PANSS 2/3 model, its modified four-factor version, the male-specific four-factor model, and two five-factorial models validated in large groups in clinical and multi-ethnic studies. Results and conclusions: (1) Structured rehabilitation therapy, compared to unstructured supportive therapy, significantly reduced the level of schizophrenia disorders defined by various factor models derived from PANSS. (2) The clinical improvement within the 3-month rehabilitation therapy course was correlated with a significant decrease in neuropeptide S (NPS) serum level. (3) The excitement/Hostility (E/H) factor, which included schizophrenic symptoms of the psychotic disorganization, was specific and selective for the reduction in serum NPS, which was stable across all analyzed factor models. (4) The long-term relationship between serum NPS and clinical factors was not accompanied by basic metabolic parameters.

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Section: Discussionmentioning

confidence: 74%

Relationship of Neuropeptide S with Clinical and Metabolic Parameters of Patients during Rehabilitation Therapy for Schizophrenia

Markiewicz-Gospodarek

Dobrowolska

Maciejewski

et al. 2022

Brain Sciences

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“…Ndel1 has unique features which include a dual role as an enzyme (oligopeptidase activity) and as a ligand protein important for the formation of complexes with several other cytosolic cytoskeleton proteins, which were demonstrated to be involved in the neurite outgrowth, neuronal precursor proliferation and differentiation, neuronal migration and brain formation (Bradshaw & Hayashi, 2017; Hayashi et al, 2010). Indeed, nuclear distribution factor E‐homolog 1 (NDE1), lissencephaly 1 (LIS1), Disrupted‐in‐Schizophrenia 1 (DISC1), as well as Ndel1 participate together in processes essential for neurodevelopment (Nani et al, 2021). Ndel1 is also involved in the regulation of microtubule organization, while only NDE1 was found substantially enriched at the centrosome during mitosis, showing parallel but distinct roles for NDE1 and Ndel1 with impacts on neurodevelopmental disorders and psychiatric illnesses (Bradshaw & Hayashi, 2017).…”

Section: Introductionmentioning

confidence: 99%

Assessing the role of Ndel1 oligopeptidase activity in congenital Zika syndrome: Potential predictor of congenital syndrome endophenotype and treatment response

Christoff,

Nani,

Lessa

et al. 2023

Journal of Neurochemistry

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Maternal infections are among the main risk factors for cognitive impairments in the offspring. Zika virus (ZIKV) can be transmitted vertically, causing a set of heterogeneous birth defects, such as microcephaly, ventriculomegaly and corpus callosum dysgenesis. Nuclear distribution element like‐1 (Ndel1) oligopeptidase controls crucial aspects of cerebral cortex development underlying cortical malformations. Here, we examine Ndel1 activity in an animal model for ZIKV infection, which was associated with deregulated corticogenesis. We observed here a reduction in Ndel1 activity in the forebrain associated with the congenital syndrome induced by ZIKV isolates, in an in utero and postnatal injections of different inoculum doses in mice models. In addition, we observed a strong correlation between Ndel1 activity and brain size of animals infected by ZIKV, suggesting the potential of this measure as a biomarker for microcephaly. More importantly, the increase of interferon (IFN)‐beta signaling, which was used to rescue the ZIKV infection outcomes, also recovered Ndel1 activity to levels similar to those of uninfected healthy control mice, but with no influence on Ndel1 activity in uninfected healthy control animals. Taken together, we demonstrate for the first time here an association of corticogenesis impairments determined by ZIKV infection and the modulation of Ndel1 activity. Although further studies are still necessary to clarify the possible role(s) of Ndel1 activity in the molecular mechanism(s) underlying the congenital syndrome induced by ZIKV, we suggest here the potential of monitoring the Ndel1 activity to predict this pathological condition at early stages of embryos or offspring development, during while the currently employed methods are unable to detect impaired corticogenesis leading to microcephaly. Ndel1 activity may also be possibly used to follow up the positive response to the treatment, such as that employing the IFN‐beta that is able to rescue the ZIKV‐induced brain injury.image

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Neuropeptidases in Psychiatric Disorders

Cited by 2 publications

References 103 publications

Relationship of Neuropeptide S with Clinical and Metabolic Parameters of Patients during Rehabilitation Therapy for Schizophrenia

Relationship of Neuropeptide S with Clinical and Metabolic Parameters of Patients during Rehabilitation Therapy for Schizophrenia

Assessing the role of Ndel1 oligopeptidase activity in congenital Zika syndrome: Potential predictor of congenital syndrome endophenotype and treatment response

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