2021
DOI: 10.1371/journal.pgen.1009456
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Neuropeptide F signaling regulates parasitoid-specific germline development and egg-laying in Drosophila

Abstract: Drosophila larvae and pupae are at high risk of parasitoid infection in nature. To circumvent parasitic stress, fruit flies have developed various survival strategies, including cellular and behavioral defenses. We show that adult Drosophila females exposed to the parasitic wasps, Leptopilina boulardi, decrease their total egg-lay by deploying at least two strategies: Retention of fully developed follicles reduces the number of eggs laid, while induction of caspase-mediated apoptosis eliminates the vitellogeni… Show more

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Cited by 15 publications
(9 citation statements)
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“…2020; K im et al . 2021; S adanandappa et al . 2021), it is possible that they may modulate either process to help promote infection tolerance.…”
Section: Resultsmentioning
confidence: 99%
“…2020; K im et al . 2021; S adanandappa et al . 2021), it is possible that they may modulate either process to help promote infection tolerance.…”
Section: Resultsmentioning
confidence: 99%
“…It is known that infected flies will alter their feeding behavior, often to avoid eating infected food ( Soldano et al 2016 ; Charroux et al 2020 ; Cai et al 2021 ), and they will alter their fecundity and egg-laying behavior ( Masuzzo et al 2019 , 2020 ), perhaps to limit the energetically costly process of reproduction while fighting infection ( Schwenke et al 2016 ). Given that several of the neuropeptide signaling molecules and pathways that we see downregulated upon infection are known to affect both feeding and reproduction ( Schoofs et al 2017 ; Ameku et al 2018 ; Nassel and Zandawala 2019 ; Hadjieconomou et al 2020 ; Kim et al 2021 ; Sadanandappa et al 2021 ), it is possible that they may modulate either process to help promote infection tolerance. Thus, enteric infection-mediated changes in both gut-to-brain signaling and CNS signaling may be a general mechanism to coordinate multiple whole-body physiological and behavioral responses to infection.…”
Section: Resultsmentioning
confidence: 99%
“…First, the sight and smell of wasps causes a rapid decline in oviposition through egg retention, coupled with apoptosis via effector caspases at a specific stage of oogenesis [ 70 , 72 ]. These parasitoid-induced changes in germ cell development are induced by suppression of neuropeptide F (NPF) signaling in the brain, which occurs following the sight of wasps [ 73 , 74 ]. The oviposition depression is triggered when the fly sees the wasp.…”
Section: Behavioral Immunity Toward Parasitoid Waspsmentioning
confidence: 99%