Neuropeptide regulation of feeding in dogs

Inui, Akio; Okita, Misako; Nakajima, Mitsutoshi; Inoue, Toru; Sakatani, Noriaki; Oya, Manabu; Morioka, H.; Okimura, Yasuhiko; Chihara, Kazuo; Baba, Shigeaki

doi:10.1152/ajpregu.1991.261.3.r588

Cited by 21 publications

(19 citation statements)

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“…In the dog, feeding was stimulated by PP, not by NPY or PYY (Inui et al, 1991). The single exception is a study with male baboons that was unable to demonstrate any e ect of central NPY administration on food intake (Sipols et al, 1996).…”

Section: British Journal Of Pharmacology Vol 135 (8)mentioning

confidence: 97%

Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig

Lecklin

Lundell

Paananen

et al. 2002

British J Pharmacology

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1 Neuropeptide Y (NPY) is one of the most potent stimulants of food intake. It has been debated which receptor subtype mediates this response. Initially Y 1 was proposed, but later Y 5 was announced as a`feeding' receptor in rats and mice. Very little is known regarding other mammals. The present study attempts to characterize the role of NPY in feeding behaviour in the distantly related guinea-pig. When infused intracerebroventricularly, NPY dose-dependently increased food intake. 2 PYY, (Leu 31 ,Pro 34 )NPY and NPY(2 ± 36) stimulated feeding, whereas NPY(13 ± 36) had no e ect. These data suggest that either Y 1 or Y 5 receptors or both may mediate NPY induced food intake in guinea-pigs. 3 The Y 1 receptor antagonists, BIBO 3304 and H 409/22 displayed nanomolar a nity for the Y 1 receptor (K i values 1.1+0.2 nM and 5.6+0.9 nM, respectively), but low a nity for the Y 2 or Y 5 receptors. When guinea-pigs were pretreated with BIBO 3304 and H 409/22, the response to NPY was inhibited. 4 The Y 5 antagonist, CGP 71683A had high a nity for the Y 5 receptor (K i 1.3+0.05 nM) without having any signi®cant activities at the Y 1 and Y 2 receptors. When CGP 71683A was infused into brain ventricles, the feeding response to NPY was attenuated. 5 The present study shows that NPY stimulates feeding in guinea-pigs through Y 1 and Y 5 receptors. As the guinea-pig is very distantly related to the rat and mouse, this suggests that both Y 1 and Y 5 receptors may mediate NPY-induced hyperphagia also in other orders of mammals.

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Section: British Journal Of Pharmacology Vol 135 (8)mentioning

confidence: 97%

Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig

Lecklin

Lundell

Paananen

et al. 2002

British J Pharmacology

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“…NPY is considered to be one of the most potent orexigenic substances known (8), and intracerebroventricular injection of PP stimulates feeding in rats, mice, and dogs (9)(10)(11)(12). Anorectic patients have high levels of circulating PP (13,14), whereas obese persons have decreased PP concentrations (15) and have lower PP release in response to meals than lean persons (16).…”

Section: All Three Peptides Have Been Found In Animal Experimentsmentioning

confidence: 99%

The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor.

Lundell

Statnick

Johnson

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

102

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Pancreatic polypeptide (PP) is produced in the islets of Langerhans and released in response to meals. It belongs to a family of peptides that also includes neuropeptide Y and peptide YY. In the present communication, we describe a rat receptor with high affinity for PP, therefore named PP1. Clones for the PP1 receptor were obtained by PCR using sequence information for the neuropeptide Y receptor Y1 from several species. The PP1 receptor has 46% overall amino acid sequence identity to the rat Y1 receptor and 56% identity in the transmembrane regions. The PP1 receptor displays a pharmacological profile that is distinct from previously described neuropeptide Y-family receptors. In competition with iodinated bovine PP, it binds rat PP with an affinity (K*) of 0.017 nM, while the affinities for peptide YY and neuropeptide Y are substantially lower with K; values of 162 and 192 nM, respectively. In stably transfected CHO cells, the PP1 receptor inhibits forskolin-stimulated cAMP synthesis. Northern blot hybridizations to a panel of mRNAs detected transcripts in testis and lung. A faint band was seen in colon and total brain. In contrast, the human receptor is expressed primarily in colon and small intestine. Whereas rat and human PP1 bind PP with the same affinity, the rat receptor has much lower affinity than its human ortholog for peptide YY and neuropeptide Y. Interestingly, the amino acid sequence identity between rat and human PP1 is only 75%. Thus, the sequence, the tissue distribution, and the binding profile of the PP1 receptor differ considerably between rat and human.The pancreatic polypeptide (PP)-fold family of neuroendocrine peptides consists of PP, neuropeptide Y (NPY), and peptide YY (PYY). All three peptides have 36 aa and share prominent sequence and three-dimensional structure similarity (1). PP is s.creted from pancreatic islets in response to meals, and it inhibits gall bladder contraction, gut motility, and pancreatic secretion (for review, see ref.2). PP has also been isolated from porcine intestine (3). PYY is found in endocrine cells of the lower intestine (4) as well as in pancreatic islets (5) and a few neuronal populations (6, 7). Its release and actions on the gastrointestinal tract are similar to those of PP (see ref.2). NPY, in contrast, is found in the central and peripheral nervous systems. All three peptides have been found in animal experimentsto increase food intake. NPY is considered to be one of the most potent orexigenic substances known (8), and intracerebroventricular injection of PP stimulates feeding in rats, mice, and dogs (9-12). Anorectic patients have high levels of circulating PP (13,14), whereas obese persons have decreased PP concentrations (15)

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“…This suggests species differences in the feeding response to CRF, as demonstrated for other peptides such as CCK (Della-Fera & Baile 1979, Morley et al 1985, Inui et al 1993) and neuropeptide Y (Inui et al 1991, Sipols et al 1996, and activation of the parasympathetic nervous system in this species.…”

Section: Discussionmentioning

confidence: 59%

“…The methods used have been described previously (Inui et al , 1988(Inui et al , 1991. Experiments were conducted 2 weeks after implantation of the cannula in the brain ventricle.…”

Section: Surgical Proceduresmentioning

confidence: 99%

Effects of corticotropin-releasing factor on feeding and pancreatic polypeptide response in the dog

Okita

Inui²,

Inoue³

et al. 1998

Journal of Endocrinology

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We have previously reported that corticotropin-releasing factor (CRF) is a potent stimulator of adrenocorticotropic hormone and cortisol secretion in the dog. Therefore, in the present study, we investigated the extrahypophysiotropic actions of CRF in this species. When CRF was injected into the third cerebral ventricle, it failed to inhibit food intake significantly at doses of 1·19, 3·57 and 11·9 nmol. This is in sharp contrast with the results in rodents. At the 3·57 and 11·9 nmol doses, CRF markedly stimulated the secretion of pancreatic polypeptide (PP), a hormone under vagal control, and at the highest dose CRF increased plasma glucose levels. These results suggest species differences in the feeding response to CRF and activation of the parasympathetic nervous system in the dog.

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Neuropeptide regulation of feeding in dogs

Cited by 21 publications

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Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig

Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig

The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor.

Effects of corticotropin-releasing factor on feeding and pancreatic polypeptide response in the dog

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Neuropeptide regulation of feeding in dogs

Cited by 21 publications

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Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea‐pig

Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea‐pig

The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor.

Effects of corticotropin-releasing factor on feeding and pancreatic polypeptide response in the dog

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Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig

Receptor subtypes Y₁ and Y₅ mediate neuropeptide Y induced feeding in the guinea‐pig