Neuropeptide S counteracts 6-OHDA-induced motor deficits in mice

Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson׳s disease

“…The rotarod test has been used as a drug free test for unilaterally 6-OHDAlesioned animals to assess akinetic symptoms and may also be used in detecting loss of TH-immunoreactive cells in the SN (Whishaw et al, 2003;Rozas et al, 1997). Our results were in agreement with previous works showing that the time spent on the rotating rod was lower in 6-OHDA-lesioned mice (Didonet et al, 2014;Kopalli et al, 2013;Im et al, 2005), and more interesting, that 6-MSITC treatment significantly improved mice's performance.…”

Neuropeptide S Increases locomotion activity through corticotropin-releasing factor receptor 1 in substantia nigra of mice

“…While these nuclei are responsible for the activation of cortical areas involved in the initiation of movements, the ultimate effect of dopamine deficiency is paucity of movement [39][40][41]. The present study aimed at exploring the mechanisms of NPS-NPSR system in neuronal circuits of the basal ganglia with locomotor activity [42]. As yet, many articles reported the distribution of NPS mRNA or NPSR mRNA in the brain in mice or rats [23,24].…”

Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson’s disease in rats

“…Group B served as the model group, and was intragastrically administered normal saline once daily for 14 consecutive days. Group C was intragastrically given madopar (L-DOPA + benserazide, 25 + 6.25 mg/kg) for 14 days [15]. Group D received HBO treatment.…”