Neuropeptide Y and Peptide YY in Association with Depressive Symptoms and Eating Behaviours in Adolescents across the Weight Spectrum: From Anorexia Nervosa to Obesity

Tyszkiewicz‐Nwafor, Marta; Jowik, Katarzyna; Dutkiewicz, Agata; Krasińska, Agata; Pytlińska, Natalia; Dmitrzak‐Węglarz, Monika; Sumińska, Marta; Pruciak, Agata; Skowrońska, Bogda; Słopień, Agnieszka

doi:10.3390/nu13020598

Cited by 12 publications

(9 citation statements)

References 108 publications

(120 reference statements)

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“…Elevated PYY levels have also been reported in critically ill patients, particularly in patients with food intolerance ( 36 ). The PYY levels were 25.49 ± 9.79 pg/mL among adolescents with anorexia nervosa and 18.46 ± 9.81 pg/mL in healthy adolescents, which is a much lower concentration than in our study, but this difference may occur due to technical differences in the tests used for the analysis ( 37 ). There were no differences in PYY levels between females and males with CF, as well as homozygous and heterozygous for ΔF508.…”

Section: Discussioncontrasting

confidence: 74%

Serum levels of hormones regulating appetite in patients with cystic fibrosis − a single-center, cross-sectional study

et al. 2022

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Cystic fibrosis (CF), which is the most common inherited genetically determined disease caused by a mutation in the gene for the CF transmembrane conductance regulator protein. Pulmonary failure is the leading cause of death in this population, while the dysregulation of endocrine system creates significant disorders, including malnutrition, underweight, and CF-related diabetes. Therefore, the objective of our study was to determine the following hormones in the serum of patients with CF: ghrelin, putative peptide YY (PYY), Agouti-signaling protein (ASP), and alpha-melanocyte-stimulating hormone (α-MSH). To our knowledge, serum levels of PYY, ASP, and α-MSH have not yet been assessed in CF. For this purpose, we measured hormone levels using enzyme-linked immunosorbent assays in 38 patients from the local CF care center, as well as 16 sex- and age-matched healthy controls. Moreover, we estimated the correlations between the tested hormones and the parameters of the patients’ clinical status. In this study, we found sinificantly reduced serum levels of ghrelin and ASP in patients with CF (p<0.01). There was no difference in PYY and α-MSH levels between participants with CF and healthy subjects. Furthermore, there was no difference in hormone levels between females and males with CF. The type of gene mutation (homozygous or heterozygous for ΔF508) had no effect on hormone levels. Ghrelin was negatively correlated with age, body mass index, and C-reactive protein. PYY was negatively associated with the age of the patients. Hormone dysregulation in CF may contribute to decreased appetite, as well as many other disturbed processes. Therefore, ghrelin appears to play a key role in the regulation of energy management of CF. Future multicenter and multidisciplinary studies should focus on an unequivocal understanding of the role of these hormones in CF.

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Section: Discussioncontrasting

confidence: 74%

Serum levels of hormones regulating appetite in patients with cystic fibrosis − a single-center, cross-sectional study

et al. 2022

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“…The levels of NPY in normal weight was (3.08±0.02 pg/ml), (Table 5) which was higher than both of overweight and obese with three classes (I, II, III), (Figure 1). These studies had reported similar results (Milewicz et al, 2000), (Baltazi et al, 2011), (Tyszkiewicz-Nwafor et al, 2021). Studies who showing that negative correlation between BMI and NPY were observed in obese and serum NPY levels were significantly lower in obese.…”

Section: Discussionmentioning

confidence: 56%

Evaluation the activity of Neuropeptide Y (NPY), Glucagon like peptide-1 and Ghrelin in controlling appetite in obesity in Erbil City

2023

ZJPAS

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The epidemic of obesity is at previously unheard-of heights. In 2016, it was predicted that 39% and 13% of individuals worldwide were overweight or obese, respectively. Obesity, which is defined as an imbalance between energy intake and expenditure, results from multiple interactions between genetic, environmental, psychological, behavioral, and nutritional variables, making it a difficult condition to study and treat. The present study aimed to approach the understanding of appetite, bodyweight regulation and the causes of obesity through studying gastrointestinal hormones such as (NPY, GLP-1, and ghrelin) hormones and their impact on controlling appetite in obesity. This comparative study included ( 152) participants (Obese and non-Obese) in the age range (30-66 years), both males and females who visited (The surgical specialty hospital cardiac center, Hawler teaching hospital, and Erbil's court). A self-administered questionnaire was used for data collection. Fasting serum metabolic parameters and hormones were measured included (S.NPY, S.GLP-1, S.Ghrelin) and (S.Total Cholesterol, S.Triglycerides, S.HDL, S.LDL, and S.VLDL). According to the BMI of participants, there was a significant association (P < 0.001) between NPY, GLP-1 hormones and BMI, and a significant (p = 0.033) association between Ghrelin and BMI. The present study concluded that serum NPY, GLP-1 and Ghrelin hormones significantly impacted controlling appetite in obesity, would be a useful and important marker to evaluation for obesity. And a strong relationship between these hormones and obesity.

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“…Disruptions in hormonal balance have been associated with various eating disorder 9 – 11 . Numerous studies have been conducted to elucidate the pathogenesis of ED, particularly involvement of “appetite-regulating hormones”, such as peptide YY (PYY) and acylated-ghrelin 12 , 13 . PYY is involved in energy intake through gastrointestinal digestion 14 , 15 , where it inhibits the orexigenic neuropeptide Y neurons in the hypothalamus as part of its central anorexigenic function 14 .…”

Section: Introductionmentioning

confidence: 99%

Proteomics of appetite-regulating system influenced by menstrual cycle and intensive exercise in female athletes: a pilot study

Tanabe,

Kamemoto,

Kawaguchi

et al. 2024

Sci Rep

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Female athletes who endure intense training are at risk of developing the 'female athlete triad,' making energy intake management crucial. However, the fluctuations in estradiol and progesterone levels throughout the menstrual cycle present a challenge in maintaining consistent energy intake. This study aimed to uncover the underlying factors associated with appetite regulation linked to menstrual phases and exercise using proteomic approach. Five female athletes engaged in 60 min of bicycle exercise, followed by 90 min of rest, during both the follicular and luteal phases. Serum samples were collected before, during, and after exercise, and the serum proteome was analyzed using 2D-gel electrophoresis. A total of 511 spots were detected in the subjects' serum profiles, with significant decreases observed in haptoglobin during the luteal phase and complement component 3 during bicycle training. Unsupervised learning with a generalized estimating equation analysis showed that serum peptide YY (PYY), an appetite suppressor, significantly influenced the fluctuations of serum proteins induced by exercise (p < 0.05). Regression analysis demonstrated a positive correlation between PYY and serum IgM (R = 0.87), implying that the intestinal environment and the immune response in female athletes may contribute to appetite regulation.

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Neuropeptide Y and Peptide YY in Association with Depressive Symptoms and Eating Behaviours in Adolescents across the Weight Spectrum: From Anorexia Nervosa to Obesity

Cited by 12 publications

References 108 publications

Serum levels of hormones regulating appetite in patients with cystic fibrosis − a single-center, cross-sectional study

Serum levels of hormones regulating appetite in patients with cystic fibrosis − a single-center, cross-sectional study

Evaluation the activity of Neuropeptide Y (NPY), Glucagon like peptide-1 and Ghrelin in controlling appetite in obesity in Erbil City

Proteomics of appetite-regulating system influenced by menstrual cycle and intensive exercise in female athletes: a pilot study

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