Neuropeptide Y as an autonomic neurotransmitter

Potter, Erica K.

doi:10.1016/0163-7258(88)90028-9

Cited by 234 publications

(72 citation statements)

References 165 publications

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“…This conclusion is consistent with the well known neuromodulatory action of NPY on autonomic nerves (Lundberg et al, 1984;Wahlestedt et al, 1986;Potter, 1988) and capsaicinsensitive sensory nerves in the guinea-pig isolated left atria, bronchi and trachea Grundemar et al, 1990). It has been previously shown by Maggi et al (1988b,c; that the activation of peripheral endings of capsaicinsensitive sensory nerves by electrical field stimulation (antidromic stimulation) and capsaicin differ in their sensitivity to a potent blocker of N-and L-type voltage-sensitive calcium channels, co-conotoxin fraction GVIA.…”

Section: Discussionsupporting

confidence: 77%

“…Neuropeptide Y (NPY) is a 36 amino acid peptide, widely distributed in the mammalian peripheral nervous system; it has been shown to be present in sympathetic nerves where it is co-localized with noradrenaline and released by electrical nerve stimulation (Lundberg et al, 1982;1984;Fried et al, 1985;Stjarne et al, 1986). A dense plexus of nerve fibres containing NPY-like immunoreactivity is present in the heart, respiratory and digestive tracts of various species (Furness et al, 1983;Lundberg et al, 1983;Sundler et al, 1983;Uddman et al, 1984;Sternini & Brecha, 1985;Potter, 1988). In addition to sympathetic NPY fibres of extramural origin, the gastrointestinal tract also contains an abundance of nerve cells and fibres containing immunoreactive NPY-like material that are devoid of noradrenaline and originate in intramural ganglia (Furness et al, 1983;Sundler et al, 1983).…”

Section: Introductionmentioning

confidence: 99%

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Prejunctional modulatory action of neuropeptide Y on responses due to antidromic activation of peripheral terminals of capsaicin‐sensitive sensory nerves in the isolated guinea‐pig ileum

Takaki

Nakayama

1991

British J Pharmacology

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1 The effect of neuropeptide Y (NPY) on motor responses produced by activation of capsaicin-sensitive primary afferents in the guinea-pig isolated ileum was determined by use of capsaicin itself and electrical mesenteric nerve stimulation as stimuli. 2 NPY inhibited or suppressed the cholinergic contractile response produced by electrical mesenteric nerve stimulation while leaving the contractile response to a threshold concentration of capsaicin. 3 NPY had no effect on motor responses produced by a submaximal concentration of substance P, the putative endogenous mediator of the 'efferent' function of sensory fibres in this preparation. 4 It is concluded that NPY exerted a prejunctional inhibitory action on transmitter release from peripheral endings of capsaicin-sensitive nerves at interneuronal synapses.

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Prejunctional modulatory action of neuropeptide Y on responses due to antidromic activation of peripheral terminals of capsaicin‐sensitive sensory nerves in the isolated guinea‐pig ileum

Takaki

Nakayama

1991

British J Pharmacology

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“…Neuropeptide Y (NPY) is a 36 amino acid peptide, widely distributed in the mammalian peripheral nervous system, which has been shown to be present in sympathetic nerves where it is co-localized with noradrenaline and released by electrical nerve stimulation (Lundberg et al, 1982;1983;1984;Fried et al, 1985;Stjarne et al, 1986). A dense plexus of nerve fibres containing NPY-like immunoreactivity is present in the heart and respiratory tract of various species (Sternini & Brecha, 1985;Lundberg et al, 1983;Uddman et al, 1984;Sheppard et al, 1984;Potter, 1988). Among other effects, NPY has been shown to exert a prejunctional inhibitory influence on transmitter release from both cholinergic and noradrenergic nerves in the guinea-pig heart (Lundberg et al, 1984;Kilborn et al, 1985;Potter, 1987).…”

Section: Introductionmentioning

confidence: 99%

Prejunctional modulatory action of neuropeptide Y on peripheral terminals of capsaicin‐sensitive sensory nerves

Giuliani

Maggi

Meli

1989

British J Pharmacology

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1 We have determined the effect of neuropeptide Y (NPY) on motor responses produced by activation of capsaicin-sensitive primary afferents in the guinea-pig isolated left atria (reserpinepretreatment, atropine in the bath) and bronchi (atropine and indomethacin in the bath) using capsaicin itself and electrical field stimulation as stimuli. 2 In both preparations, NPY inhibited or suppressed the response produced by electrical field stimulation while leaving the response to a submaximal concentration of capsaicin unaffected. 3 NPY had no effect on motor responses produced by a submaximal concentration of calcitonin gene-related peptide (atria) or neurokinin A (bronchi), the putative endogenous mediators of the responses produced by activation of the 'efferent' function of sensory fibres in these preparations. 4 We conclude that NPY exerts a prejunctional inhibitory action on transmitter release from peripheral endings of capsaicin-sensitive nerves. Failure of NPY to modulate responses activated by capsaicin provides further evidence for the existence of two independent modes of activation of the 'efferent' function of capsaicin-sensitive sensory nerves.

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“…Sympathetic nerves contain either norepinephrine, or norepinephrine plus neuropeptide Y (NPY) [7]. Norepinephrine and NPY are both vasoconstrictors, but NPY is slower in onset, and very long in duration [8]. The presence of both NPY-containing nerves and NPY binding sites on arteriovenous anastomoses suggests that NPY acts as a vasoconstrictor at this key location in vivo.…”

Section: Peripheral Stimuli Leading To Nasal Reflexes Exercisementioning

confidence: 99%

Nasal reflexes: Implications for exercise, breathing, and sex

Baraniuk

Merck²

2008

Curr Allergy Asthma Rep

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Nasal patency, with both congestion and decongestion, is affected in a wide variety of reflexes. Stimuli that lead to nasal reflexes include exercise, alterations of body position, pressure, and temperature, neurological syndromes, and dentists. As anticipated, the vagal and trigeminal systems are closely integrated through nasobronchial and bronchonasal reflexes. However, perhaps of greater pathophysiological importance are the naso-hypopharyngea-laryngeal reflexes that become aggravated during sinusitis. None other than Sigmund Freud saw deeply beyond the facial adornment and recognized the deeper sexual tensions that can regulate nasal functions and psychoanalytical status. Wine, women and song are linked with airflow through the nose, the nose, that by any other name would still smell as sweetly.

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Neuropeptide Y as an autonomic neurotransmitter

Cited by 234 publications

References 165 publications

Prejunctional modulatory action of neuropeptide Y on responses due to antidromic activation of peripheral terminals of capsaicin‐sensitive sensory nerves in the isolated guinea‐pig ileum

Prejunctional modulatory action of neuropeptide Y on responses due to antidromic activation of peripheral terminals of capsaicin‐sensitive sensory nerves in the isolated guinea‐pig ileum

Prejunctional modulatory action of neuropeptide Y on peripheral terminals of capsaicin‐sensitive sensory nerves

Nasal reflexes: Implications for exercise, breathing, and sex

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