2013
DOI: 10.1016/j.jdiacomp.2013.06.007
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Neuropeptide Y autoantibodies in patients with long-term type 1 and type 2 diabetes and neuropathy

Abstract: Neuropeptide Y autoantibodies in patients with long-term type 1 and type 2 diabetes and neuropathy. Link to publication Citation for published version (APA): Skärstrand, H., Dahlin, L. B., Lernmark, Å., & Vaziri Sani, F. (2013). Neuropeptide Y autoantibodies in patients with long-term type 1 and type 2 diabetes and neuropathy. Journal of Diabetes and its Complications, 27(6), 609-617. DOI: 10.1016/j.jdiacomp.2013 General rights Copyright and moral rights for the publications made accessible in the public port… Show more

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Cited by 11 publications
(12 citation statements)
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“…The 11% frequency of NPYA (NPY‐LA only, NPY‐PA only, or both) supports the conclusion that NPY is a minor autoantigen in T1D . Our finding that NPY‐LA was detected in 9% and NPY‐PA in 8% (p < 0.001) is of interest as Swedish T1D patients were reported to represent 90% NPY‐L only (TT genotype), 9% both NPY‐P and NPY‐L (T/C genotype), and 1% NPY‐P only .…”
Section: Discussionsupporting
confidence: 80%
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“…The 11% frequency of NPYA (NPY‐LA only, NPY‐PA only, or both) supports the conclusion that NPY is a minor autoantigen in T1D . Our finding that NPY‐LA was detected in 9% and NPY‐PA in 8% (p < 0.001) is of interest as Swedish T1D patients were reported to represent 90% NPY‐L only (TT genotype), 9% both NPY‐P and NPY‐L (T/C genotype), and 1% NPY‐P only .…”
Section: Discussionsupporting
confidence: 80%
“…In contrast to T1D, the C‐allele has been found among 10–11% of T2D patients compared to 5–6% in the general population . Further studies, are therefore also warranted in T2D patients as we also found NPYA in long‐term T2D patients .…”
Section: Discussionmentioning
confidence: 57%
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“…As antibodies to neural myelin antigens have been identified in demyelinating diseases (Allen, Giannopoulos et al 2005), an increase of IgG immunoglobulins in SCN may similarly due to an increase in neural autoantigens. For example, neuropeptide y ( Npy ), a widely expressed protein in the peripheral nervous system that is increased in response to nerve injury (Ji, Zhang et al 1994) is a DEG in our female BTBR ob/ob mice and is a known autoantigen in T1D and T2D patients (Skarstrand, Dahlin et al 2013). Interestingly, Mmp12 and S100a8 are involved in inflammation, tissue remodeling, and injury.…”
Section: Discussionmentioning
confidence: 99%
“…This is where autonomic failure occurs in the presence of antibodies to the nicotinic acetylcholine receptor of autonomic ganglia, leading to severe autonomic manifestations, eg, orthostatic intolerance, syncope, constipation, gastroparesis, urinary retention, dry mouth, dry eyes, anhidrosis, and cognitive impairment 52,53. However, the role of autoimmunity in patients with diabetes and CAN remains controversial 5457. A recent small cross-sectional study did show that the presence of IgG antibodies was associated with AN (OR 9, 95% CI 1.3–61.03) 58.…”
Section: Pathogenesis Of Canmentioning
confidence: 99%