2011
DOI: 10.1152/ajpcell.00358.2010
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Neuropeptide Y inhibits cholangiocarcinoma cell growth and invasion

Abstract: No information exists on the role of neuropeptide Y (NPY) in cholangiocarcinoma growth. Therefore, we evaluated the expression and secretion of NPY and its subsequent effects on cholangiocarcinoma growth and invasion. Cholangiocarcinoma cell lines and nonmalignant cholangiocytes were used to assess NPY mRNA expression and protein secretion. NPY expression was assessed by immunohistochemistry in human liver biopsies. Cell proliferation and migration were evaluated in vitro by MTS assays and matrigel invasion ch… Show more

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Cited by 28 publications
(35 citation statements)
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“…The decrease of NPY secretion in proliferating BDL cholangiocytes rats is consistent with the concept that NPY is a local antiproliferative factor. A similar local mechanism has been detected in biliary tumors, where we demonstrated that NPY expression is upregulated in cholangiocarcinoma, which exerts local control on tumor cell proliferation and invasion (6). High NPY concentrations were detected in tissue extracts of liver, gallbladder, cystic, and bile ducts (1,8).…”
Section: Discussionsupporting
confidence: 79%
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“…The decrease of NPY secretion in proliferating BDL cholangiocytes rats is consistent with the concept that NPY is a local antiproliferative factor. A similar local mechanism has been detected in biliary tumors, where we demonstrated that NPY expression is upregulated in cholangiocarcinoma, which exerts local control on tumor cell proliferation and invasion (6). High NPY concentrations were detected in tissue extracts of liver, gallbladder, cystic, and bile ducts (1,8).…”
Section: Discussionsupporting
confidence: 79%
“…Treatment of colon carcinoma cells reduced their invasion potential in vitro (26). Also, NPY inhibits cholangiocarcinoma growth in both in vivo and in vitro models (6).…”
Section: Discussionmentioning
confidence: 99%
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“…Expressed IL-6 in stable Mz-ChA-1 cell line/5 Â 10 6 (þ) miR-148a /152, (À) DNMT1 [2] Expressed IL-6 in stable Mz-ChA-1 cell line/3 Â 10 6 (À) miR-370 [3] Expressed miR-494 in stable HuCCT1/3.25 Â 10 6 (À) G1-S transition, (À) tumour growth [4,5 & ] Gene knockdown Slug siRNA in stable QBC939 cell line/5 Â 10 6 (À) Tumour growth [6] CypA siRNA in stable M139 cell line /3 Â 10 6 (À) Tumour growth [7] Beclin-1 siRNA in stable QBC939 cell line/2 Â 10 6 (À) Tumour growth [8 & ] Drug treatment during xenograft development Sk-ChA-1 cells/5 Â 10 6 /tamoxifen injections intratumourally (þ) Apoptosis [9] Mz-ChA-1 cells/5 Â 10 6 /resveratrol i.p injection (þ) Sensitivity to a chemotherapeutic agent [10] Mz-ChA-1 cells/5 Â 10 6 /anti-NYP antibody injections intratumourally (þ) Tumour growth [11] Mz-ChA-1 cells/5 Â 10 6 /green tea polyphenol EGCG i.p injection (þ) Chemotherapy-induced apoptosis [12] QBC939 cells/2 Â 10 6 /magnetic nanoparticles injections by caudal vein (þ) Tumour growth [13] catabolic process involving the degradation of a cell's own components through the lysosomal machinery. Autophagy is activated in CCA, and inactivation of autophagy may lead to cell apoptosis and enhance chemotherapy sensitivity.…”
Section: Key Pointsmentioning
confidence: 99%