Neuropeptide Y-like immunoreactivity in neurons of the human retina

Straznicky, Charles; Hiscock, Jennifer

doi:10.1016/0042-6989(89)90051-5

Cited by 34 publications

(42 citation statements)

References 21 publications

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“…Similar NPY-immunoreactive cells have been found in the pigeon retina (VERSTAPPEN et al, 1986). Amacrine cells with widefield dendritic arbors seen in some anuran retina (HISCOCK and STRAZNICKY, 1989) were not seen in lizard retina.…”

Section: Discussionsupporting

confidence: 53%

“…The morphology of NPY-immunoreactive amacrine cells NPY-immunoreactive amacrine cells have been found in the retinae of many species including the goldfish (OSBORNE et al, 1985), frog (HISCOCK and STRAZNICKY, 1989), turtle (ISAYAMA and ELDRED,1988) and pigeon (VERSTAPPEN et al, 1986). In these species NPY-immunoreactive amacrine cells represent morphologically distinct cell types with unistratified, bistratified or multistratified dendritic branching in the IPL.…”

Section: Discussionmentioning

confidence: 99%

“…In most species it has been localized to amacrine cells (BRECHA and KARTEN, 1985;OSBORNE et al, 1985;HISCOCK and STRAZNICKY, 1989), although some bipolar cells in Rana temporaria (BRUUN et al, 1986) and large ganglion cells in the human retina (STRAZNICKY and HlscocK, 1989) also displayed NPY-like immunoreactivity. Information about the possible presence of NPYlike immunoreactivity in retinal neurons in reptiles is scarce.…”

Section: Gouldiimentioning

confidence: 99%

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Neuropeptide Y-Immunoreactive Neurons in the Retina of Two Australian Lizards.

Straznicky

Hiscock

1994

Archives of Histology and Cytology

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Gouldiimentioning

confidence: 99%

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Neuropeptide Y-Immunoreactive Neurons in the Retina of Two Australian Lizards.

Straznicky

Hiscock

1994

Archives of Histology and Cytology

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“…NPY immunoreactivity is present in human, cat, guinea pig, mouse, and rat retinas (Bruun et al, 1984;Tornqvist and Ehinger, 1988;Ferriero and Sagar, 1989;Straznicky and Hiscock, 1989;Li and Lam, 1990;Jen et al, 1994; Chalupa, 1994, 1995;Ammar et al, 1998;Kang et al, 2001;Oh et al, 2001;Sinclair and Nirenberg, 2001). This peptide is mainly localized to amacrine cells and displaced amacrine cells and, in cat and human retinas, to small ganglion cells.…”

Section: Nih-pa Author Manuscriptmentioning

confidence: 99%

“…Y-receptors have been localized to specific regions of the central and peripheral nervous system by receptor binding autoradiography, immunohistochemistry, and in situ hybridization (Zhang et al, 1994;Bao et al, 1997;Jacques et al, 1997;Dumont et al, 1998;Hökfelt et al, 1998;Gackenheimer et al, 2001). Y1 receptor is the most studied Y-receptor and it plays key roles in many of the central and peripheral effects of NPY (Lundberg et al, 1996;Munglani et al, 1996;Balasubramaniam, 1997;Blomqvist and Herzog, 1997).NPY immunoreactivity is present in human, cat, guinea pig, mouse, and rat retinas (Bruun et al, 1984;Tornqvist and Ehinger, 1988;Ferriero and Sagar, 1989;Straznicky and Hiscock, 1989;Li and Lam, 1990;Jen et al, 1994; Chalupa, 1994, 1995;Ammar et al, 1998;Kang et al, 2001;Oh et al, 2001;Sinclair and Nirenberg, 2001). This peptide is mainly localized to amacrine cells and displaced amacrine cells and, in cat and human retinas, to small ganglion cells.…”

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Localization of neuropeptide Y1 receptor immunoreactivity in the rat retina and the synaptic connectivity of Y1 immunoreactive cells

D'Angelo¹,

Oh²,

Chun³

et al. 2002

J of Comparative Neurology

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Neuropeptide Y (NPY), an inhibitory neuropeptide expressed by a moderately dense population of wide-field amacrine cells in the rat retina, acts through multiple (Y1-y6) G-protein-coupled receptors. This study determined the cellular localization of Y1 receptors and the synaptic connectivity of Y1 processes in the inner plexiform layer (IPL) of the rat retina. Specific Y1 immunoreactivity was localized to horizontal cell bodies in the distal inner nuclear layer and their processes in the outer plexiform layer. Immunoreactivity was also prominent in cell processes located in strata 2 and 4, and puncta in strata 4 and 5 of the IPL. Double-label immunohistochemical experiments with calbindin, a horizontal cell marker, confirmed Y1 immunostaining in all horizontal cells. Double-label immunohistochemical experiments, using antibodies to choline acetyltransferase and vesicular acetylcholine transporter to label cholinergic amacrine cell processes, demonstrated that Y1 immunoreactivity in strata 2 and 4 of the IPL was localized to cholinergic amacrine cell processes. Electron microscopic studies of the inner retina showed that Y1-immunostained amacrine cell processes and puncta received synaptic inputs from unlabeled amacrine cell processes (65.2%) and bipolar cell axon terminals (34.8%). Y1-immunoreactive amacrine cell processes most frequently formed synaptic outputs onto unlabeled amacrine cell processes (34.0%) and ganglion cell dendrites (54.1%). NPY immunoreactivity in the rat retina is distributed primarily to strata 1 and 5 of the IPL, and the present findings, thus, suggest that NPY acts in a paracrine manner on Y1 receptors to influence both horizontal and amacrine cells. Indexing termsamacrine cells; choline acetyltransferase; calcium binding protein; horizontal cells; neuropeptides Neuropeptide Y (NPY) has multiple physiologic actions in both the central and peripheral nervous system, including effects on blood flow, memory retention, food intake, epilepsy, and pain (Lundberg et al., 1996;Munglani et al., 1996;Balasubramaniam, 1997;Blomqvist and Herzog, 1997;Thorsell et al., 2000;Furtinger et al., 2001;Naveilhan et al., 2001). These NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript effects are mediated by means of at least five G-protein-coupled receptors, designated as Y1, Y2, Y4, Y5, and y6, which are coupled to pertussis toxin-sensitive inhibitory Gproteins (Lundberg et al., 1996;Munglani et al., 1996;Balasubramaniam, 1997;Blomqvist and Herzog, 1997;Michel et al., 1998). Y-receptors have been localized to specific regions of the central and peripheral nervous system by receptor binding autoradiography, immunohistochemistry, and in situ hybridization (Zhang et al., 1994;Bao et al., 1997;Jacques et al., 1997;Dumont et al., 1998;Hökfelt et al., 1998;Gackenheimer et al., 2001). Y1 receptor is the most studied Y-receptor and it plays key roles in many of the central and peripheral effects of NPY (Lundberg et al., 1996;Munglani et al., 1996;Balasubramaniam, 1997;Blomqvist and H...

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Expression of UDP‐N‐acetyl‐α‐D‐galactosamine–polypeptide galNAc N‐acetylgalactosaminyl transferase‐3 in relation to differentiation and prognosis in patients with colorectal carcinoma

Shibao

Izumi

Nakayama

et al. 2002

Cancer

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Neuropeptide Y (NPY), an inhibitory neuropeptide expressed by a moderately dense population of wide‐field amacrine cells in the rat retina, acts through multiple (Y1–y6) G‐protein–coupled receptors. This study determined the cellular localization of Y1 receptors and the synaptic connectivity of Y1 processes in the inner plexiform layer (IPL) of the rat retina. Specific Y1 immunoreactivity was localized to horizontal cell bodies in the distal inner nuclear layer and their processes in the outer plexiform layer. Immunoreactivity was also prominent in cell processes located in strata 2 and 4, and puncta in strata 4 and 5 of the IPL. Double‐label immunohistochemical experiments with calbindin, a horizontal cell marker, confirmed Y1 immunostaining in all horizontal cells. Double‐label immunohistochemical experiments, using antibodies to choline acetyltransferase and vesicular acetylcholine transporter to label cholinergic amacrine cell processes, demonstrated that Y1 immunoreactivity in strata 2 and 4 of the IPL was localized to cholinergic amacrine cell processes. Electron microscopic studies of the inner retina showed that Y1‐immunostained amacrine cell processes and puncta received synaptic inputs from unlabeled amacrine cell processes (65.2%) and bipolar cell axon terminals (34.8%). Y1‐immunoreactive amacrine cell processes most frequently formed synaptic outputs onto unlabeled amacrine cell processes (34.0%) and ganglion cell dendrites (54.1%). NPY immunoreactivity in the rat retina is distributed primarily to strata 1 and 5 of the IPL, and the present findings, thus, suggest that NPY acts in a paracrine manner on Y1 receptors to influence both horizontal and amacrine cells. J. Comp. Neurol. 454:373–382, 2002. © 2002 Wiley‐Liss, Inc.

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Neuropeptide Y-like immunoreactivity in neurons of the human retina

Cited by 34 publications

References 21 publications

Neuropeptide Y-Immunoreactive Neurons in the Retina of Two Australian Lizards.

Neuropeptide Y-Immunoreactive Neurons in the Retina of Two Australian Lizards.

Localization of neuropeptide Y1 receptor immunoreactivity in the rat retina and the synaptic connectivity of Y1 immunoreactive cells

Expression of UDP‐N‐acetyl‐α‐D‐galactosamine–polypeptide galNAc N‐acetylgalactosaminyl transferase‐3 in relation to differentiation and prognosis in patients with colorectal carcinoma

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