Neuropeptide Y receptor 1 and galanin receptor 2 (NPY1R-GALR2) interactions in the dentate gyrus and their relevance for neurogenesis and cognition

Beltran-Casanueva, Rasiel; Hernández-García, Aracelis; de Amo García, Paula; Blanco-Reina, Encarnación; Serrano-Castro, Pedro; García-Casares, Natalia; Fuxe, Kjell; Borroto-Escuela, Dasiel O.; Narváez, Manuel

doi:10.3389/fncel.2024.1323986

Cited by 3 publications

(1 citation statement)

References 59 publications

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“…Subsequent study revealed a sustained increase in neurogenesis in the dorsal dentate gyrus following ICV administration of GALR2 and NPY1R agonists. Simultaneous delivery of the M1145 and the NPY1R agonist promoted neuroblast proliferation and improvement in object-in-place memory [ 69 ]. Additionally, galanin receptor-2/3 agonist (Gal 2-11) induced proliferation of hippocampal precursor cells, thus directly affected hippocampal neurogenesis, impaired in AD, through production of granule cell neurons of the dentate gyrus [ 70 ].…”

Section: Orexigenic Neuropeptidesmentioning

confidence: 99%

Anorexigenic neuropeptides as anti-obesity and neuroprotective agents

Strnadová,

Pačesová,

Charvát

et al. 2024

Bioscience Reports

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Since 1975, the incidence of obesity has increased to epidemic proportions, and the number of patients with obesity has quadrupled. Obesity is a major risk factor for developing other serious diseases, such as type 2 diabetes mellitus, hypertension, and cardiovascular diseases. Recent epidemiologic studies have defined obesity as a risk factor for the development of neurodegenerative diseases, such as Alzheimer's disease (AD) and other types of dementia. Despite all these serious comorbidities associated with obesity, there is still a lack of effective antiobesity treatment. Promising candidates for the treatment of obesity are anorexigenic neuropeptides, which are peptides produced by neurons in brain areas implicated in food intake regulation, such as the hypothalamus or the brainstem. These peptides efficiently reduce food intake and body weight. Moreover, because of the proven interconnection between obesity and the risk of developing AD, the potential neuroprotective effects of these two agents in animal models of neurodegeneration have been examined. The objective of this review was to explore anorexigenic neuropeptides produced and acting within the brain, emphasizing their potential not only for the treatment of obesity but also for the treatment of neurodegenerative disorders.

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Section: Orexigenic Neuropeptidesmentioning

confidence: 99%

Anorexigenic neuropeptides as anti-obesity and neuroprotective agents

Strnadová,

Pačesová,

Charvát

et al. 2024

Bioscience Reports

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Central administration of galanin-like peptide (GALP) causes short-term orexigenic effects in broilers: Mediatory role of NPY1 and D1 receptors

Sanadgol,

Zendehdel,

Vazir

et al. 2025

Neuroscience Letters

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Hormonal and Allosteric Regulation of the Luteinizing Hormone/Chorionic Gonadotropin Receptor

Shpakov

2024

Front. Biosci. (Landmark Ed)

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Luteinizing hormone (LH) and human chorionic gonadotropin (CG), like follicle-stimulating hormone, are the most important regulators of the reproductive system. They exert their effect on the cell through the LH/CG receptor (LHCGR), which belongs to the family of G protein-coupled receptors. Binding to gonadotropin induces the interaction of LHCGR with various types of heterotrimeric G proteins (Gs, Gq/11, Gi) and β-arrestins, which leads to stimulation (Gs) or inhibition (Gi) of cyclic adenosine monophosphate-dependent cascades, activation of the phospholipase pathway (Gq/11), and also to the formation of signalosomes that mediate the stimulation of mitogen-activated protein kinases (β-arrestins). The efficiency and selectivity of activation of intracellular cascades by different gonadotropins varies, which is due to differences in their interaction with the ligand-binding site of LHCGR. Gonadotropin signaling largely depends on the status of N- and O-glycosylation of LH and CG, on the formation of homo- and heterodimeric receptor complexes, on the cell-specific microenvironment of LHCGR and the presence of autoantibodies to it, and allosteric mechanisms are important in the implementation of these influences, which is due to the multiplicity of allosteric sites in different loci of the LHCGR. The development of low-molecular-weight allosteric regulators of LHCGR with different profiles of pharmacological activity, which can be used in medicine for the correction of reproductive disorders and in assisted reproductive technologies, is promising. These and other issues regarding the hormonal and allosteric regulation of LHCGR are summarized and discussed in this review.

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Neuropeptide Y receptor 1 and galanin receptor 2 (NPY1R-GALR2) interactions in the dentate gyrus and their relevance for neurogenesis and cognition

Cited by 3 publications

References 59 publications

Anorexigenic neuropeptides as anti-obesity and neuroprotective agents

Anorexigenic neuropeptides as anti-obesity and neuroprotective agents

Central administration of galanin-like peptide (GALP) causes short-term orexigenic effects in broilers: Mediatory role of NPY1 and D1 receptors

Hormonal and Allosteric Regulation of the Luteinizing Hormone/Chorionic Gonadotropin Receptor

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