Neuropeptide Y stimulates proliferation, migration and differentiation of neural precursors from the subventricular zone in adult mice

Decressac, Mickaël; Prestoz, Laetitia; Veran, Julien; Cantereau, Anne; Jaber, Mohamed; Gaillard, Afsaneh

doi:10.1016/j.nbd.2009.02.017

Cited by 72 publications

(61 citation statements)

References 42 publications

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“…(43) Similarly, NPY has been shown in mice to promote the proliferation of neuronal progenitor cells in the dentate gyrus of the hippocampus (28,44) and also in the subventricular zone. (45,46) Interestingly, in all cases, the Y receptor mediating these effects is the Y1 receptor. Our findings in the study of stem cells in the bone environment further advance these insights to show that Y1 may act as a master switch that may increase bone and fat formation via effects on MSCs.…”

Section: Discussionmentioning

confidence: 99%

Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity

Lee

Doyle

Sainsbury

et al. 2010

Journal of Bone and Mineral Research

103

135

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The neuropeptide Y (NPY) system has been implicated in the regulation of bone homeostasis and osteoblast activity, but the mechanism behind this is unclear. Here we show that Y1 receptor signaling is directly involved in the differentiation of mesenchymal progenitor cells isolated from bone tissue, as well as the activity of mature osteoblasts. Importantly, the mRNA levels of two key osteogenic transcription factors, runx2 and osterix, as well as the adipogenic transcription factor PPAR-g, were increased in long bones of Y1 À/À mice compared with wild-type mice. In vitro, bone marrow stromal cells (BMSCs) isolated from Y1 À/À mice formed a greater number of mineralized nodules under osteogenic conditions and a greater number of adipocytes under adipogenic conditions than controls. In addition, both the number and size of fibroblast colony-forming units formed in vitro by purified osteoprogenitor cells were increased in the absence of the Y1 receptors, suggestive of enhanced proliferation and osteogenesis. Furthermore, the ability of two specific populations of mesenchymal progenitor cells isolated from bone tissue, an immature mesenchymal stem cell population and a more committed osteoprogenitor cell population, to differentiate into osteoblasts and adipocytes in vitro was enhanced in the absence of Y1 receptor signaling. Finally, Y1 receptor deletion also enhanced the mineral-producing ability of mature osteoblasts, as shown by increased in vitro mineralization by BMSCs isolated from osteoblast-specific Y1 À/À mice. Together these data demonstrate that the NPY system, via the Y1 receptor, directly inhibits the differentiation of mesenchymal progenitor cells as well as the activity of mature osteoblasts, constituting a likely mechanism for the high-bone-mass phenotype evident in Y1 À/À mice. ß

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Section: Discussionmentioning

confidence: 99%

Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity

Lee

Doyle

Sainsbury

et al. 2010

Journal of Bone and Mineral Research

103

135

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“…Additionally, factors able to promote proliferation and neuronal differentiation have been described previously. NPY, for instance, promotes proliferation and neuronal differentiation in the rodent dentate gyrus and SVZ (Howell et al, 2005;Agasse et al, 2008b;Decressac et al, 2009). TNF␣ and VEGF display pro-proliferative and proneurogenic capacities in SVZ cultures (Jin et al, 2002;Bernardino et al, 2008;Wittko et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

The Angiogenic Factor Angiopoietin-1 Is a Proneurogenic Peptide on Subventricular Zone Stem/Progenitor Cells

Rosa¹,

Gonçalves²,

Cortes³

et al. 2010

J. Neurosci.

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Section: Neuropeptide Ymentioning

confidence: 99%

“…Studies using knockout mice and receptor-specific modulators found that the Y1 receptor is essential for the NPY-mediated effect on progenitor proliferation (Hansel et al, 2001;Howell et al, 2005;Agasse et al, 2008;Decressac et al, 2009). A recent study points towards an epistatic relationship between NPY and NO signaling REVIEW Development 140 (12) (Cheung et al, 2012).…”

Section: Neuropeptide Ymentioning

confidence: 99%

“…In the hippocampus, NPY is expressed by the GABAergic interneurons that are situated in the hilus and in the DG (Köhler et al, 1986;Freund and Buzsáki, 1996). In vivo and in vitro studies show that NPY has a pro-proliferative effect in both the SVZ and the SGZ (Howell et al, 2005;Agasse et al, 2008;Decressac et al, 2009;Thiriet et al, 2011).Studies using knockout mice and receptor-specific modulators found that the Y1 receptor is essential for the NPY-mediated effect on progenitor proliferation (Hansel et al, 2001;Howell et al, 2005;Agasse et al, 2008;Decressac et al, 2009). A recent study points towards an epistatic relationship between NPY and NO signaling REVIEW Development 140 (12) (Cheung et al, 2012).…”

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confidence: 99%

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Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain

et al. 2013

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SummaryIt was long thought that no new neurons are added to the adult brain. Similarly, neurotransmitter signaling was primarily associated with communication between differentiated neurons. Both of these ideas have been challenged, and a crosstalk between neurogenesis and neurotransmitter signaling is beginning to emerge. In this Review, we discuss neurotransmitter signaling as it functions at the intersection of stem cell research and regenerative medicine, exploring how it may regulate the formation of new functional neurons and outlining interactions with other signaling pathways. We consider evolutionary and cross-species comparative aspects, and integrate available results in the context of normal physiological versus pathological conditions. We also discuss the potential role of neurotransmitters in brain size regulation and implications for cell replacement therapies. Key words: Adult neurogenesis, Homeostasis, Neural stem cell, Neurotransmitter, Regeneration IntroductionIn the brain, signaling via neurotransmitters, small molecules released by neurons to communicate with other cells, has primarily been associated with the function rather than with the formation of neurons. However, several reports have identified roles for neurotransmitters in cell fate determination in a wide range of species both within and outside the central nervous system (CNS). A thorough discussion on the evolutionary origin of neurotransmitter signaling is outside the scope of this Review, but it is important to note that both neurotransmitters and their receptors (see Table 1) are present and functionally important in organisms without a nervous system. For example, γ-aminobutyric acid (GABA), glutamate and nitric oxide (NO) have all been detected in sponges and shown to regulate cell behavior (Ellwanger et al., 2007;Elliott and Leys, 2010). A recent transcriptome profiling of the sponge A. queenslandica revealed the expression of wide repertoire of components active in synapses found in the vertebrate nervous systems (Conaco et al., 2012). In the social amoeba Dictysotelium, disruption of a glutamate receptor by homologous recombination reveals a role for glutamate signaling in the suppression of cell division (Taniura et al., 2006), while GABA induces terminal differentiation of spores through a GABA B receptor (Anjard and Loomis, 2006). GABA and glutamate appear to play opposing roles in spore induction (Fountain, 2010) in Dictyostelium, indicating that the apparent antagonistic relationship between glutamate and GABA signaling was established prior to the evolution of synaptic communication in the CNS.Furthermore, neurotransmitters control cell proliferation during development long before the onset of neurogenesis in mammals, as exemplified by GABA signaling in the early embryo (Andäng et al., 2008). Once developmental neurogenesis is initiated, neurotransmitter signaling has an impact on several aspects of neurogenesis, including proliferation, migration and differentiation in various locations in the CNS, such as the tele...

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Neuropeptide Y stimulates proliferation, migration and differentiation of neural precursors from the subventricular zone in adult mice

Cited by 72 publications

References 42 publications

Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity

Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity

The Angiogenic Factor Angiopoietin-1 Is a Proneurogenic Peptide on Subventricular Zone Stem/Progenitor Cells

Neurotransmitter-mediated control of neurogenesis in the adult vertebrate brain

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