Neuropeptide Y Y₁ Receptors Meditate Targeted Delivery of Anticancer Drug with Encapsulated Nanoparticles to Breast Cancer Cells with High Selectivity and Its Potential for Breast Cancer Therapy

Abstract

By enabling nanoparticle-based drug delivery system to actively target cancer cells with high selectivity, active targeted molecules have attracted great attention in the application of nanoparticles for anticancer drug delivery. However, the clinical application of most active targeted molecules in breast cancer therapy is limited, due to the low expression of their receptors in breast tumors or coexpression in the normal and tumor breast tissues. Here, a neuropeptide Y Y1 receptors ligand PNBL-NPY, as a novel targeted molecule, is conjugated with anticancer drug doxorubicin encapsulating albumin nanoparticles to investigate the effect of Y1 receptors on the delivery of drug-loaded nanoparticles to breast cancer cells and its potential for breast cancer therapy. The PNBL-NPY can actively recognize and bind to the Y1 receptors that are significantly overexpressed on the surface of the breast cancer cells, and the drug-loaded nanoparticles are delivered directly into the cancer cells through internalization. This system is highly selective and able to distinguish the breast cancer cells from the normal cells, due to normal breast cells that express Y2 receptors only. It is anticipated that this study may provide a guidance in the development of Y1 receptor-based nanoparticulate drug delivery system for a safer and more efficient breast cancer therapy.

Manganese-Zeolitic Imidazolate Frameworks-90 with High Blood Circulation Stability for MRI-Guided Tumor Therapy

“…Neuropeptide Y Y 1 receptor (Y 1 R) is highly overexpressed in human breast tumors and metastases (above 90%), while the normal breast tissues express Y 2 R only [41]. Recently, we found that Y 1 R ligands, such as [Pro 30 , Nle 31 , Bpa 32 , Leu 34 ]-NPY (28)(29)(30)(31)(32)(33)(34)(35)(36) and [Asn 6 , Pro 34 ]-NPY, play important roles in tumor-targeted imaging and therapy with high selectivity to breast tumors and less effect on other organs [39,42,43]. Especially, these Y 1 R ligands can reduce premature drug release during blood circulation due to their different spatial configurations under different pH conditions [39].…”

Kinetic investigation for the catalytic reduction of nitrophenol using ionic liquid stabilized gold nanoparticles

“…Metal nanoparticles of different sizes, shapes, and composition have many important catalytic applications [1][2][3][4] as well as applications in biosensing, 5 optoelectronics, 6 petroleum industries, chemical conversion, biology, 7 etc. Gold nanoparticles (AuNPs) have attracted considerable interest due to their exceptionally high surface-to-volume ratios and abundance of edge and corner atoms.…”

Targeting of peptide‐binding receptors on cancer cells with peptide‐drug conjugates

“…However, all of these approaches use nanoparticle‐based platforms, decorated with hY 1 R‐binding peptides as targeting units. [ 126–129 ]…”