1991
DOI: 10.1111/1523-1747.ep12470630
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Neuropeptides Enhance Irritant and Allergic Contact Dermatitis

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Cited by 56 publications
(33 citation statements)
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“…This confirms our previous data using NEP Ϫ/Ϫ -mice demonstrating that the lack of NEP does not affect ICD responses to croton oil or SDS (24). However, other studies also demonstrated an involvement of SP and sensory nerves in both allergic and irritant inflammation (37)(38)(39)(40)(41). The precise mechanism of this difference between nonspecific irritant inflammation and the hapten-specific ACD response in mice with functionally inactive proteolytic peptidases such as ACE or NEP compared with wild-type animals is not entirely clear.…”
Section: Figure 6 Icd Responses In Acesupporting
confidence: 90%
“…This confirms our previous data using NEP Ϫ/Ϫ -mice demonstrating that the lack of NEP does not affect ICD responses to croton oil or SDS (24). However, other studies also demonstrated an involvement of SP and sensory nerves in both allergic and irritant inflammation (37)(38)(39)(40)(41). The precise mechanism of this difference between nonspecific irritant inflammation and the hapten-specific ACD response in mice with functionally inactive proteolytic peptidases such as ACE or NEP compared with wild-type animals is not entirely clear.…”
Section: Figure 6 Icd Responses In Acesupporting
confidence: 90%
“…Girolomoni et al (28) showed that neuropeptide depletion by capsaicin treatment attenuated the CHS responses induced by oxazolone and DNFB. Gutwald et al (29) reported that CGRP administration at both the sensitization and elicitation phases enhanced oxazolone-induced CHS. In contrast, the administration of a CGRP antagonist was shown to reduce FITCinduced CHS (25).…”
Section: Discussionmentioning
confidence: 99%
“…SP agonists or SP antagonists are capable of augmenting (26,27) or inhibiting (28,29) cutaneous cellular immune responses, respectively. The epicutaneous application of SP has also been reported to increase ear-swelling responses during ACD expression in a murine model of contact dermatitis (30,31). In contrast to SP, calcitonin gene-related peptide is capable of inhibiting cutaneous allergic responses (32,33).…”
Section: Discussionmentioning
confidence: 99%