Neuropeptides go the distance for circadian synchrony

Freeman, G. Mark; Herzog, Erik D.

doi:10.1073/pnas.1110844108

Cited by 9 publications

(4 citation statements)

References 19 publications

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“…In mammals, the absence of VIP/VPAC2 signaling within the suprachiasmatic nuclei results in the loss of both synchronized circadian rhythms (Aton and Herzog, ; Vosko et al, ) and the inability to appropriately encode information provided by photoperiod (Lucassen et al, ). The suprachiasmatic nuclei is proposed to encode daily and seasonal information by regulating clock gene expression via VIP and GPCR/cAMP signaling (Freeman and Herzog, ). Input from the suprachiasmatic nuclei to the ovary is predicted to occur through both hormonal and neural signals that, in turn, phase clock gene expression.…”

Section: Introductionmentioning

confidence: 99%

Vasoactive intestinal peptide promotes differentiation and clock gene expression in granulosa cells from prehierarchal follicles

Kim

Johnson

2016

Molecular Reproduction Devel

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Vasoactive intestinal peptide (VIP) signaling via cyclic adenosine monophosphate (cAMP) is reported to stimulate steroidogenesis in ovarian granulosa cells from a variety of vertebrate species, including the domestic hen. Prior to follicle selection in the hen ovary (i.e., cyclic recruitment) follicle-stimulating-hormone (FSH)-induced cAMP signaling is absent within the granulosa layer until immediately following follicle selection. As a consequence, granulosa cells remain in an undifferentiated state and are unable to initiate FSH-induced steroidogenesis. VIP receptors (VPAC1 and VPAC2), like the FSH receptor, are G protein-coupled receptors, so we predicted that VIP signaling in granulosa cells is also absent in follicles that have not yet been selected into the preovulatory hierarchy. Initial studies established that mRNA encoding VPAC1 and VPAC2 are expressed within the granulosa cells throughout follicle development. Nevertheless, undifferentiated granulosa cells from prehierarchal (6-8 mm) follicles do not accumulate cAMP in response to a 4-hr incubation with chicken VIP; the capacity for such receptor signaling is attained only following selection within actively differentiating granulosa cells. VIP treatment did, however, increase expression of mRNA encoding the Gallus circadian clock protein, BMAL1-but only in granulosa cells collected from selected follicles. These findings provide evidence that, at follicle selection, the acquisition of VIP-induced cAMP cell signaling helps initiate and promote the differentiation of of granulosa cells. Furthermore, we propose that VIP signaling may regulate BMAL1 expression and, thus, a daily rhythmicity within granulosa cells of preovulatory follicles. Mol. Reprod. Dev. 83: 455-463, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 99%

Vasoactive intestinal peptide promotes differentiation and clock gene expression in granulosa cells from prehierarchal follicles

Kim

Johnson

2016

Molecular Reproduction Devel

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“…84 Transplant studies of the SCN indicate that diffusible factors can mediate the circadian rhythmicity of locomotion through the CSF. 77,78,[85][86][87] This diffusible signal could include the peptides AVP (arginine-vasopressin) 88 and VIP, which are expressed by the SCN and detectable in the CSF. 89,90 CSF orexins from the hypothalamus decrease in the inactive phase, directly coupling the sleep-wake cycle with CSF.…”

Section: Compendium: Circadian Mechanisms In Cardio/ Cerebrovascular ...mentioning

confidence: 99%

“…In addition to serving as a fluid cushion, waste sink, and buffer for the brain, CSF plays critical roles in regulating the CNS throughout life, including distributing essential health- and growth-promoting factors. 74 CSF production, 70,75 composition, 76–81 and glymphatic clearance/distribution 56,73 change substantially throughout the 24-hour day. As a direct modulator of CSF volume and composition, the choroid plexus has been the subject of growing interest for its important roles in brain development and health.…”

Section: Rhythms At the Interface Of Csf And Blood: The Choroid Plexusmentioning

confidence: 99%

Circadian Mechanisms in Brain Fluid Biology

Vizcarra,

Fame,

Hablitz

2024

Circulation Research

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The brain is a complex organ, fundamentally changing across the day to perform basic functions like sleep, thought, and regulating whole-body physiology. This requires a complex symphony of nutrients, hormones, ions, neurotransmitters and more to be properly distributed across the brain to maintain homeostasis throughout 24 hours. These solutes are distributed both by the blood and by cerebrospinal fluid. Cerebrospinal fluid contents are distinct from the general circulation because of regulation at brain barriers including the choroid plexus, glymphatic system, and blood-brain barrier. In this review, we discuss the overlapping circadian (≈24-hour) rhythms in brain fluid biology and at the brain barriers. Our goal is for the reader to gain both a fundamental understanding of brain barriers alongside an understanding of the interactions between these fluids and the circadian timing system. Ultimately, this review will provide new insight into how alterations in these finely tuned clocks may lead to pathology.

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“…SCN-explants obtained from these animals showed normal circadian clock oscillation, indicating that Prok2 is not a regulator of the core-clock itself but acts as an output signal of the SCN and directly affects the locomotor activity (Prosser et al, 2007). Finally, neuropeptidergic release from the SCN has been shown to be essential for the synchronization of the individual cells of the SCN (Freeman and Herzog, 2011).…”

Section: Humoral Communication Of the Scnmentioning

confidence: 96%

Spatio-temporal Approach to Transport Dynamics in the Mammalian Ventricular System

Johanna¹

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Neuropeptides go the distance for circadian synchrony

Cited by 9 publications

References 19 publications

Vasoactive intestinal peptide promotes differentiation and clock gene expression in granulosa cells from prehierarchal follicles

Vasoactive intestinal peptide promotes differentiation and clock gene expression in granulosa cells from prehierarchal follicles

Circadian Mechanisms in Brain Fluid Biology

Spatio-temporal Approach to Transport Dynamics in the Mammalian Ventricular System

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