Neuropeptides: Influence of acute and chronic effects of opiates

Krivoy, William A.; Kroeger, Donald C.; Zimmermann, E.

doi:10.1016/0306-4530(77)90030-0

Cited by 35 publications

(11 citation statements)

References 28 publications

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“…Within physiological limits, in both developing and adult organisms, ACTH exerts enhancing influences on neural and behavioral efficiency in contrast to the largely depressing influences of BE (Sandman & Kastin, 1990). For instance, in animal models ACTH fragments administered concomitantly with opiates attenuated tolerance and dependence (Hendrie, 1989; Krivoy, Kroeger, & Zimmerman, 1977; Szekely et al, 1979). Similar examples of reciprocity were reported for generation of characteristic waveforms (‘eliptogenic’ spiking) in the electroencephalogram of the nucleus gigantocellularis following periaqueductal gray stimulation [Sandman & Kastin, 1981], social behavior (Beckwith, Sandman, Hothersall, & Kaston, 1976; Panskepp, Herman, Conner, Bishop, & Scott, 1978) learning and memory in the rodent (Sandman, Alexander, & Kastin, 1973, Sandman, Miller, Kastin, & Schally, 1972; Beckwith et al, 1976; McGivern, Berka, Berntson, Walker, & Sandman, 1979) and human fetal learning (Sandman et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

The role of proopiomelanocortin (POMC) in sequentially dependent self‐injurious behavior

Sandman

Touchette

Marion

et al. 2008

Developmental Psychobiology

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Self-injuring behavior (SIB) is a life-threatening behavior exhibited by many species, including humans, and has no known cause and no agreed upon treatment. The role of the stress axis in the maintenance of this mysterious behavior was examined in subjects with life-long SIB. Over a sixyear period, forty hours of direct observations of behavior and the environment were recorded on palmtop computers while 36 residential subjects (28 target and 8 control subjects) conducted their daily activities. Blood samples were collected in morning and evening for all subjects and within minutes after a self-injuring act in 28 target subjects who exhibited SIB to determine levels of ACTH and B-endorphin (BE). Self-injuring events in the patient group were significantly sequentially dependent (i.e. the only predictor of a self-injuring act was an antecedent self-injuring act). Higher morning levels of BE relative to ACTH predicted [r df=27 =0.57, p<.001] the sequentially dependent pattern of SIB. This effect was validated in a subgroup re-tested several months later [r df=22 =0.60, p<.001]. A subgroup of seven subjects exhibiting sequentially dependent patterns were administered an opiate blocker (naltrexone) in a double-blind, crossover design with an additional 14 hours/week of observation for seven weeks. Naltrexone challenge interrupted the sequential pattern (improved behavior) in subjects with elevated BE immediately following SIB (r=0.85, p<0.01). The pattern of results supported the conclusion that the stress axis played a significant role in the maintenance of complex episodes of self-injury.

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Section: Discussionmentioning

confidence: 99%

The role of proopiomelanocortin (POMC) in sequentially dependent self‐injurious behavior

Sandman

Touchette

Marion

et al. 2008

Developmental Psychobiology

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“…Within physiological limits, in both developing and adult organisms, ACTH exerts enhancing influences on neural and behavioral efficiency in contrast to the reciprocal and largely depressing influences of BE [Sandman and Kastin, 1990]. For instance, ACTH fragments administered concomitantly with opiates attenuate tolerance and dependence [Hendrie, 1988;Krivoy et al, 1977;Szekely et al, 1979]. Similar examples of reciprocity are reported for generation of characteristic waveforms ('eliptogenic' spiking) in the electroencephalogram of the nucleus gigantocellularis following periaqueductal gray stimulation [Sandman and Kastin, 1981], social behavior [Beckwith et al, 1977;Panskepp et al, 1978] and learning [Sandman et al, 1972[Sandman et al, , 1973Beckwith et al, 1977;McGivern et al, 1979].…”

mentioning

confidence: 99%

Maternal Hypothalamic-Pituitary-Adrenal Disregulation during the Third Trimester Influences Human Fetal Responses

Sandman¹,

Glynn²,

Wadhwa

et al. 2003

Dev Neurosci

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Maternal peptides from the hypothalamic-pituitary-adrenal (HPA) axis rise during human pregnancy. The effects of circulating maternal adrenocorticotropin (ACTH) and β-endorphin (BE) on human fetal behavior was determined in 135 women during their 32nd week of gestation. Fetal behavior was measured by assessing heart rate habituation to a series of repeated vibroacoustic stimuli. Individual differences in habituation were determined by computing the number of consecutive responses above the standard deviation during a control period. There was no significant relation between levels of ACTH, BE and the rate of fetal heart rate habituation. However, an index of HPA disregulation (uncoupling of ACTH and BE) was related significantly to fetal behavior. Fetal exposure to high levels of maternal BE relative to ACTH was associated with significantly lower rates of habituation. Results indicate that maternal stress and stress-related peptides influence fetal response patterns. It is possible that this influence persists over the life span.

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“…The evidence that ACTH can interact with opiate receptors in the central nervous system and in the periphery (Krivoy et al, 1977;Gispen et al, 1976;Terenius et al, 1975;Wiegant et al, 1977) suggests the possibility that Ci iy H-NALOXONE + 50 mg/Kg H-MORPHINE + 10 mg/Kg ACTH 000µU) Figure 3.-The effect of pretreatment with the stereoisomeric forms of morphine or naloxone on the adrenal island steroidogenic response to ACTH and the adrenal res p onse to morphine following naloxone pretreatment. Asterisks indicate significant differences from the group administered ACTH alone (n = 10), at 1> ^ 0.05.…”

Section: Discussionmentioning

confidence: 99%

“…It has been demonstrated that ACTH can competitively inhibit opiate binding in vitro showing mixed agonist-antagonist actions (Krivoy et al, 1977;Terenius et al, 1975;Wiegant et al, 1977). In vivo studies have shown that naloxone blocks the effect of chronic ACTH treatment in retarding the development of reproductive function in mice (Yasukawa et al, 1978).…”

mentioning

confidence: 99%

Naloxone inhibits and morphine potentiates the adrenal steroidogenic response to ACTH

Heybach

Vernikos

1981

European Journal of Pharmacology

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Neuropeptides: Influence of acute and chronic effects of opiates

Cited by 35 publications

References 28 publications

The role of proopiomelanocortin (POMC) in sequentially dependent self‐injurious behavior

The role of proopiomelanocortin (POMC) in sequentially dependent self‐injurious behavior

Maternal Hypothalamic-Pituitary-Adrenal Disregulation during the Third Trimester Influences Human Fetal Responses

Naloxone inhibits and morphine potentiates the adrenal steroidogenic response to ACTH

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