Neuropharmacological effects induced by butanol, 4-hydroxybutyrate, 4-mercaptobutyric acid thiolactone, tetrahydrofuran, pyrrolidine, 2-deoxy-d-glucose and related substances in the rat

Marcus, Robert J.; Winters, Wendell D.; Hultin, Eskil

doi:10.1016/0028-3908(76)90094-0

Cited by 18 publications

(3 citation statements)

References 39 publications

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“…The failure of both the dopamine receptor stimulants apomorphine and piribedil and blocker haloperidol to modulate the 7-HB-induced ecog hypersynchrony, in the present study, indicates that inhibition of the nigrostriatal dopaminergic system is not likely to be responsible for the y-HB hypersynchrony. This is in accordance with observations that striatectomy has no influence on the eeg and behavioural effects of y-HB in the cat (Marcus, Winters & Hultin, 1976) and that in the rat, after striatectoniy, leptazol eeg seizures remain unaltered, while the threshold for convulsions is elevated (Avakyan, 1976).…”

Section: Discussionsupporting

confidence: 93%

The role of dopaminergic systems in γ-hydroxybutyrate-induced electrocorticogram hypersynchronization in the rat

Godschalk

Dzoljic

Bonta

1977

Journal of Pharmacy and Pharmacology

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The effects of dopaminergic agonists and antagonists on the duration of hypersynchronization induced in the electrocorticogram (ecog) by γ‐hydroxybutyrate (γ‐HB) were tested in rats. Apomorphine (0·2–8 mg kg−1), piribedil (2·5–10 mg kg−1) and haloperidol (0·5–1 mg kg−1) had no influence on the duration of the hypersynchrony. Amphetamine (1·5–6 mg kg−1) inhibited the hypersynchrony, while (3,4‐dihydroxyphenylamino)‐2‐imidazoline (DPI; 5, but not 1, mg kg−1) prolonged its duration. The lack of effect of the dopamine receptor agonists apomorphine and piribedil, and the dopamine receptor blocker haloperidol, on the γ‐HB‐induced hypersynchrony might indicate that the inhibition of the impulse flow in the nigrostriatal dopamine system by γ‐HB is not involved in the generation of the hypersynchrony. DPI is thought to be an agonist at a dopamine receptor not sensitive to apomorphine, and its facilitatory effect on γ‐HB‐hypersynchrony can be interpreted in terms of a possible involvement of another dopamine system in the ecog hypersynchrony induced by γ‐HB. The antagonism of γ‐HB by amphetamine is possibly due to an indirect stimulatory effect on noradrenergic receptors.

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Section: Discussionsupporting

confidence: 93%

The role of dopaminergic systems in γ-hydroxybutyrate-induced electrocorticogram hypersynchronization in the rat

Godschalk

Dzoljic

Bonta

1977

Journal of Pharmacy and Pharmacology

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“…1. This molecule is an analog of yhydroxybutyrate, which has been shown in rodents (Marcus et al, 1976;Godschalk et al, 1977) and monkeys (Snead, 1978) to be capable of inducing symmetrical spikeand-wave discharges on the EEG.…”

Section: Structure Analogous Tomentioning

confidence: 99%

Electroencephalographic and Behavioral Effects of a GABA Agonist (Muscimol) on Photosensitive Epilepsy in the Baboon, Papio papio

Pedley

Horton²,

Bs³

1979

Epilepsia

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Muscimol, 0.25-1.0 mg/kg, i.v., was administered acutely to 4 adolescent baboons, Papio papio, that show photically induced epilepsy. On the EEG, slowing of background rhythms was associated with the appearance of spikes, polyspikes, and recurring symmetrical spike-wave complexes. These changes were maximal 0.5-2 hr after muscimol injection. Regular testing with intermittent light stimulation showed either no change from control responses or a more severe epileptiform EEG 0.1-3 hr after muscimol. Photically induced myoclonus was not modified by muscimol. Despite its GABA-abonist properties, muscimol is not an effective anticonvulsant.

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“…Bamford et al (1970) demonstrated the intravenous anesthetic activity of THF in mice. Marcus et al (1976) reported that THF administration (21 mmol/kg, i.p.) induced high-amplitude slow wave EEG activity, induced the loss of the of the righting reflex, and induced myoclonic jerks and vibrissae movements in response to tactile stimulation in rats.…”

Section: Introductionmentioning

confidence: 99%

Neuropharmacological profile of tetrahydrofuran in mice

et al. 2007

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Neuropharmacological effects induced by butanol, 4-hydroxybutyrate, 4-mercaptobutyric acid thiolactone, tetrahydrofuran, pyrrolidine, 2-deoxy-d-glucose and related substances in the rat

Cited by 18 publications

References 39 publications

The role of dopaminergic systems in γ-hydroxybutyrate-induced electrocorticogram hypersynchronization in the rat

The role of dopaminergic systems in γ-hydroxybutyrate-induced electrocorticogram hypersynchronization in the rat

Electroencephalographic and Behavioral Effects of a GABA Agonist (Muscimol) on Photosensitive Epilepsy in the Baboon, Papio papio

Neuropharmacological profile of tetrahydrofuran in mice

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