Neuropharmacological insights into Gardenia jasminoides Ellis: Harnessing therapeutic potential for central nervous system disorders

Hou, Ziyu; Sun, Le; Jiang, Zheyu; Zeng, Tiexin; Wu, Peiling; Huang, Jiali; Liu, Haibo; Xiao, Peigen

doi:10.1016/j.phymed.2024.155374

Phytomedicine

2024

DOI: 10.1016/j.phymed.2024.155374

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Neuropharmacological insights into Gardenia jasminoides Ellis: Harnessing therapeutic potential for central nervous system disorders

Ziyu Hou,

Le Sun,

Zheyu Jiang

et al.

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Cited by 6 publications

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The role of gastrodin in the management of CNS‐related diseases: Underlying mechanisms to therapeutic perspectives

He,

Chen,

Yang

et al. 2024

Phytotherapy Research

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Central nervous system (CNS)‐related diseases have a high mortality rate, are a serious threat to physical and mental health, and have always been an important area of research. Gastrodin, the main active metabolite of Gastrodia elata Blume, used in Chinese medicine and food, has a wide range of pharmacological effects, mostly related to CNS disorders. This review aims to systematically summarize and discuss the effects and underlying mechanisms of gastrodin in the treatment of CNS diseases, and to assess its potential for further development as a lead drug in both biomedicine and traditional Chinese medicine. Studies on the pharmacological effects of gastrodin on the CNS indicate that it may exert anti‐neurodegenerative, cerebrovascular protective, and ameliorative effects on diabetic encephalopathy, perioperative neurocognitive dysfunction, epilepsy, Tourette's syndrome, depression and anxiety, and sleep disorders through various mechanisms. To date, 110 gastrodin products have been approved for clinical use, but further multicenter clinical case–control studies are relatively scarce. Preclinical studies have confirmed that gastrodin can be used to treat CNS‐related disorders. However, important concerns need to be addressed in the context of likely non‐specific, assay interfering effects when gastrodin is studied using in vitro and in silico approaches, calling for a systematic assessment of the evidence to date. High‐quality clinical trials should have priority to evaluate the therapeutic safety and clinical efficacy of gastrodin. Further experimental research using appropriate in vivo models is also needed, focusing on neurodegenerative diseases, cerebral ischemic and hypoxic diseases, brain damage caused by methamphetamine or heavy metals, and epilepsy.

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The role of gastrodin in the management of CNS‐related diseases: Underlying mechanisms to therapeutic perspectives

He,

Chen,

Yang

et al. 2024

Phytotherapy Research

View full text Add to dashboard Cite

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Exploration on the chemical essence of key substances affecting the quality difference of Gardenia jasminoides Ellis: A new cascade strategy for tracing the superior raw origin of homologous materials of both medicine and food

Zhu,

Gan,

Wang

et al. 2024

Industrial Crops and Products

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Genipin 1-O-β-D-gentiobioside ameliorates CUMS-induced prefrontal cortex neuron neuronal apoptosis by modulating HIPK2 SUMOylation

Xia,

Jiang,

Zhao

et al. 2024

International Immunopharmacology

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Neuropharmacological insights into Gardenia jasminoides Ellis: Harnessing therapeutic potential for central nervous system disorders

Cited by 6 publications

References 153 publications

The role of gastrodin in the management of CNS‐related diseases: Underlying mechanisms to therapeutic perspectives

The role of gastrodin in the management of CNS‐related diseases: Underlying mechanisms to therapeutic perspectives

Exploration on the chemical essence of key substances affecting the quality difference of Gardenia jasminoides Ellis: A new cascade strategy for tracing the superior raw origin of homologous materials of both medicine and food

Genipin 1-O-β-D-gentiobioside ameliorates CUMS-induced prefrontal cortex neuron neuronal apoptosis by modulating HIPK2 SUMOylation

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