Neuropharmacological potential of Ceriscoides turgida (Roxb.) leaf and root in mice

Hafiz, Wahid; Zilani, Md. Nazmul Hasan; Sultana, Nazneen; Isalm, Mahmodul; Anisuzzman,

doi:10.1186/s40816-019-0099-x

Cited by 8 publications

(11 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hole board test was performed as stated by the previously reported method [19]. A hole board apparatus is a smooth and plain board (45 cm × 45 cm) having 16 circular small holes with uniform spacing.…”

Section: Hole Board Testmentioning

confidence: 99%

In Vivo Neuropharmacological Potential of Gomphandra tetrandra (Wall.) Sleumer and In-Silico Study against β-Amyloid Precursor Protein

Rahman¹,

Zilani²,

Islam³

et al. 2021

Processes

View full text Add to dashboard Cite

Medicinal plants possess a surplus of novel and biologically active secondary metabolites that are responsible for counteracting diseases. Traditionally, Gomphandra tetrandra (Wall.) Sleumer is used to treat mental disorders. The present research was designed to explore phytochemicals from the ethanol leaf extract of Gomphandra tetrandra (Wall.) Sleumer to identify the potential pharmacophore(s) in the treatment of neurological disorders. The chemical compounds of the experimental plant were identified through GC-MS analysis. In-vitro antioxidant activity was assessed using different methods. Furthermore, in-vivo neurological activity was assessed in Swiss-albino mice. Computer-aided analysis was appraised to determine the best-fit phytoconstituent of a total of fifteen identified compounds in the experimental plant extract against beta-amyloid precursor protein. The experimental extract revealed fifteen compounds in GC-MS analysis and the highest content was 9, 12, 15-octadecatrienoic acid (z,z,z). The extract showed potent antioxidant activity in in-vitro assays. Furthermore, in in-vivo neurological assays, the extract disclosed significant (p < 0.05) neurological activity. The most favorable phytochemicals as neurological agents were selected via ADMET profiling, and molecular docking was studied with beta-amyloid precursor protein. In the computer-aided study, 1, 5-diphenyl-2h-1, 2, 4-triazoline-3-thione (Pub Chem CID: 2802516) was more active than other identified compounds with strong binding affinity to beta-amyloid precursor protein. The present in vivo and in silico studies revealed neuropharmacological features of G. tetrandra leaf extract as a natural agent against neurological disorders, especially Alzheimer’s disease.

show abstract

Section: Hole Board Testmentioning

confidence: 99%

In Vivo Neuropharmacological Potential of Gomphandra tetrandra (Wall.) Sleumer and In-Silico Study against β-Amyloid Precursor Protein

Rahman¹,

Zilani²,

Islam³

et al. 2021

Processes

View full text Add to dashboard Cite

show abstract

“…The hole board test was performed as stated by the previously reported method [19]. A hole board apparatus is a smooth and plain board (45cm × 45 cm) having 16 circular small holes with uniform spacing.…”

Section: Hole Board Testmentioning

confidence: 99%

In vivo Neuropharmacological Potential of <em>Gomphandra tetrandra</em> (Wall.) Sleumer and in-silico Study against β-Amyloid Precursor Protein

Rahman¹,

Zilani²,

Islam³

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Medicinal plants possess a surplus of novel and biologically active secondary metabolites that are responsible for counteracting diseases. Traditionally, Gomphandra tetrandra (Wall.) Sleumer is used to treat mental disorders. The present research was designed to explore phytochemicals from the ethanol leaf extract of Gomphandra tetrandra (Wall.) Sleumer to identify the potential pharmacophore(s) in the treatment of neurological disorders. The chemical compounds of the experimental plant were identified through GC-MS analysis. Besides, in-vitro antioxidant activity was assessed using different methods. Furthermore, in-vivo neurological activity was assessed in Swiss-albino mice. Computer aided analysis was appraised to determine the best-fit phytoconstituent of a total of fifteen identified compounds in the experimental plant extract against beta-amyloid precursor protein. The experimental extract revealed fifteen compounds in GC-MS analysis and the highest content was 9, 12, 15-octadecatrienoic acid (Z, Z, Z). Also, the extract showed potent anti-oxidant activity in in-vitro assays. Furthermore, in in-vivo neurological assays, the extract disclosed significant (p<0.05) neurological activity. The most favorable phytochemicals as neurological agents were selected via ADMET profiling and molecular docking was studied with beta-amyloid precursor protein. Moreover, in the computer aided study, 1, 5-Diphenyl-2H-1, 2, 4-triazoline-3-thione (Pub Chem CID: 2802516) was more active than other identified compounds with strong binding affinity to beta-amyloid precursor protein. The present in vivo and in silico studies revealed neuropharmacological features of G. tetrandra leaves extract as a natural agent against neurological disorders, especially Alzheimer’s disease.

show abstract

“…After respective treatment, animals were placed individually in one of the corner squares and the number of squares crossed by the animals was recorded for three minutes on 0, 30, 60, 90, and 120 min during the study period. The experiments were carried out in a sound-attenuated room [28] .…”

Section: Neuropharmacological Activity Testmentioning

confidence: 99%

Comparative Pharmacological Potential of Ceriops decandra (Griff.) and Ceriops tagal Linn: Medicinal Plants of the Sundarbans

Ahad¹,

Zilani²,

Akter³

et al. 2021

J. Med. Plants Stud.

Self Cite

View full text Add to dashboard Cite

Background: Ceriops decandra (Griff.) Ding Hou is used conventionally for managing a number of therapeutic conditions including diabetes, haemorrhage, pain, diarrhea, angina, and dysentery etc. Furthermore, Ceriops tagal Linn is used to treat hemorrhage, acariasis, wound infection, malaria, malignant diabetes and ulcers etc in folk medicine. The present study was designed to evaluate the comparative pharmacological activities of leaves of these two medicinal plants of the Sundarbans. Methods: Antioxidant activity was assessed by total phenolic, total flavonoids, total tannin content, and DPPH free radical scavenging assays. Acetic acid-induced test for analgesic, oral glucose tolerance test for antihyperglycemic, open field test for neurobehavioral, prothrombin time test for anticoagulant, anthelmintic potential on Paramphistomum cervi, and in-vivo cytotoxicity test on brine shrimp nauplii were used for appraising pharmacological activities of both extracts. Results: C. decandra extract revealed greater radical scavenging activity than that of C. tagal. C. decandra extract significantly (P < 0.05) reduced writhing inhibition of 54.55% and 66.37% at 500mg/kg and 250 mg/kg, respectively. In oral glucose tolerance test, C. decandra significantly lowered the blood glucose level for pretreated mice with glucose by 25.76%, 2272%, and 31.88%, 38.71% respectively, at 60 min and 120min at the 250 mg/kg, and 500 mg/kg dose level. But, the reduction of blood glucose level by C. tagal extract was less than that of C. decandra. Furthermore, C. decandra produced a sedative effect at both doses starting from 30 min to 120 min of experimental period. The crude extract of C. decandra and C. tagal delayed the prothrombin time in a dose dependently. The C. decandra and C. tagal produced dose-dependent paralysis and death time. The LC50 values obtained from brine shrimp lethality bioassay were 94.69, 114.29 µg/mL for C. decandra and C. tagal, respectively. Conclusion: C. decandra revealed prominent pharmacological activities than that of C. tagal. Also, the present study confirmed the scientific evidence of both plants.

show abstract

Neuropharmacological potential of Ceriscoides turgida (Roxb.) leaf and root in mice

Cited by 8 publications

References 17 publications

In Vivo Neuropharmacological Potential of Gomphandra tetrandra (Wall.) Sleumer and In-Silico Study against β-Amyloid Precursor Protein

In Vivo Neuropharmacological Potential of Gomphandra tetrandra (Wall.) Sleumer and In-Silico Study against β-Amyloid Precursor Protein

In vivo Neuropharmacological Potential of <em>Gomphandra tetrandra</em> (Wall.) Sleumer and in-silico Study against β-Amyloid Precursor Protein

Comparative Pharmacological Potential of Ceriops decandra (Griff.) and Ceriops tagal Linn: Medicinal Plants of the Sundarbans

Contact Info

Product

Resources

About