Neuropharmacological properties of Mikania scandens (L.) Willd. (Asteraceae)

Dey, Protapaditya; Chandra, Sangita; Chatterjee, Priyanka; Bhattacharya, Sanjib

doi:10.4103/2231-4040.90883

Cited by 29 publications

(12 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, no significant effect in the locomotor activity was observed with crude E. milii methanolic extract however a significant decrease ( P < 0.01) was observed with Au-EM as compared to diazepam ( P < 0.001), thus indicating that its sedative properties is due to its motor depressant effect in mice. Most of the centrally acting analgesics influence the locomotor activities by reducing the motor activity because of their CNS depressant property [ 66 ]. Locomotor activity is considered as an index of wakefulness or alertness of mental activity and a decrease activity is indicative of calmness and sedation as a result of reduced CNS excitability [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive, muscle relaxant and sedative activities of gold nanoparticles generated by methanolic extract of Euphorbia milii

Islam

Khan

Rauf

et al. 2015

BMC Complement Altern Med

View full text Add to dashboard Cite

BackgroundNanotechnology has potential future for enhancing therapeutic efficacy and reducing the unwanted effects of herbal drugs. The biological research on Euphorbia species has been supported by the use of some plants in traditional medicines. Many species of Euphorbia have been reported as having strong sedative and analgesic effects. In the present research work gold nanoparticles of Euphorbia milii methanolic extract (Au-EM) were synthesized, characterized and tested for antinociceptive, muscle relaxant and sedative activities.MethodsAu-EM was prepared by stirring 1 mM warm trihydrated tetrachloroaurate solution with E. milii methanolic extract without using any external reducing agents. The gold nanoparticles were characterized by UV-Visible spectroscopy, infrared spectrophotometery, atomic force microscopy and scanning electron microscopy while their stability was evaluated against varying pH and different volumes of sodium chloride (NaCl). The metal sensing capacity of Au-EM was tested towards cobalt, copper, lead, mercury and nickel. Au-EM was evaluated in BALB/c mice at a dose of 10 and 20 mg/kg for antinociceptive, muscle relaxant and sedative activities in comparison with the crude E. milii methanolic extract.ResultsAu-EM showed remarkable stability in different NaCl and pH solutions. Au-EM produced significant (P < 0.01) antinociceptive effect at doses of 10 and 20 mg/kg as compared to the crude E. milii methanolic extract. In the rotarod test, Au-EM showed significant muscle relaxant effect at 10 mg/kg (P < 0.05) and 20 mg/kg (P < 0.01) after 30, 60 and 90 min. In an open field test significant sedative effect (P < 0.05) of Au-EM was observed at 10 and 20 mg/kg. Moreover significant detection sensitivity was demonstrated towards all the tested heavy metals.ConclusionsThese results concluded that the gold nanoparticles improved the potency of E. milii methanolic extract and exhibited significant analgesic, muscle relaxant and sedative properties. The significant metals sensing ability and enhanced stability in different NaCl and pH solutions may enable us to explore different formulations of E. milii gold nanoparticles for potentially effective and safe nano-herbal therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Antinociceptive, muscle relaxant and sedative activities of gold nanoparticles generated by methanolic extract of Euphorbia milii

Islam

Khan

Rauf

et al. 2015

BMC Complement Altern Med

View full text Add to dashboard Cite

show abstract

“…The results of the study provided evidence that the extracts reduced locomotor activity confirming its CNS depressant potential. Locomotor activity is considered as an index of alertness and a reduction of it is an indicative of sedative or CNS depressant activity [40]. Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system [41], which is also involved in other physiological functions related to behavior and in various psychological and neurological disorders such as epilepsy, anxiety, depression, parkinson syndrome, and alzheimer's disease [42].…”

Section: Discussionmentioning

confidence: 99%

“…Earlier investigation of the phytoconstituents of medicinal plants suggests that many flavonoids and neuroactive steroids are ligands for GABA A receptors in the central nervous system which suggests that they can act as benzodiazepine-like agents [40]. It has also been reported that some flavanoids exhibit high affinity binding to the benzodiazepine site of GABA A receptors.…”

Section: And 5)mentioning

confidence: 99%

“…Research has shown that plants containing flavonoids, saponins and tannins are useful for the treatment of many CNS disorders [40]. Earlier investigation of the phytoconstituents of medicinal plants suggests that many flavonoids and neuroactive steroids are ligands for GABA A receptors in the central nervous system which suggests that they can act as benzodiazepine-like agents [40].…”

Section: And 5)mentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of Analgesic, Anti-inflammatory and CNS Depressant Potential of Dendrophthoe falcata (Linn.) Leaves Extracts in Experimental Mice Model

Haque¹,

Zaman²,

Hossain³

et al. 2014

Am. J. Biomed. Sci.

View full text Add to dashboard Cite

Plants are extraordinary reservoir of bioactive natural products, many of which exhibit chemical and structural features on outstanding biological activities in animals. Dendrophthoe falcata (Linn.) is an important parasitic plant extensively used in folk medicine. In this regard, the aim of this study was to investigate the possible analgesic, anti-inflammatory and central nervous system (CNS) depressant activities of ethanol, aqueous, chloroform and petroleum ether extracts of D. falcata (Linn.) leaves (AEDFL, EEDFL, CEDFL and PEDFL) on Swiss albino mice. The analgesic activity was determined by tail immersion and acetic acid induced writhing methods at a dose of 50, 100 and 200 mg/kg, p.o. using morphine sulfate as a standard drug at a dose of 5mg/kg of body weight. Carrageenan-induced paw edema model was applied to find out anti-inflammatory potential at the same doses of analgesic activity. Here ibuprofen was treated as a standard drug at 10mg/kg body weight. The CNS depressant effect of the extracts were evaluated by using open field and hole cross tests. All the extracts exhibited significant (P b < 0.01, P a < 0.001) analgesic, antiinflammatory and CNS depressant effects at dose dependant manner. Petroleum ether extracts (PEDFL) showed maximum analgesic effect ( in hole cross test respectively) CNS-depressant activities after 120 min of oral administration of the extract at 200mg/kg dose.

show abstract

“…This shows that flavonoids especially apigenin and EGCG have hypnotic effects. Flavonoids are ligands for GABAA receptors in the CNS that show effects such as benzodiazepines (Bhattacharya et al, 2011). These flavonoids exhibit high affinity bonds in the GABAAbenzodiazepine binding receptor Roth and Roehrs, 2003;Rustay et ak., 2003) so that they have anxiolytic effects, sedation, decreased motor activity (Netto et al, 2009), and hypnotics (Olayiwola et al, 2007).…”

Section: Male Mice In Vivo Test Effect Of Functional Beverages On Motmentioning

confidence: 99%

Optimization formulation of chamomile-based functional beverage as hypnotic agent using response surface method

Pristya

Widyaningsih

2019

AFSSAAE

View full text Add to dashboard Cite

Apigenin EGCG Functional beverages Insomnia Insomnia problem can be treated by consuming herbs containing apigenin and EGCG. Chamomile and green tea water extract have been found to contain apigenin and EGCG. Optimization of the formulation of those herbs is necessary to obtain the highest hypnotic activity. The purpose of this study was to optimize formulation of chamomile, green tea, and cinnamon to obtain functional beverage containing the highest phenolic and flavonoid content, but the lowest caffeine content. The best formula of the herbs was then tested in caffeine-induced mice to see the hypnotic effect. The research design in this experiment was Response Surface Model (RSM) using Central Composite Design (CCD) method. The in vivo test used Post Test Only Control Group Design. Consisting five groups of 30 male mice divided to 6 mice for each group. The optimum formula for functional beverages suggested by RSM was chamomile: green tea: cinnamon of 70.32: 30.35 : 4.99. The verification results showed that the actual response of this optimum formula had a total phenol of 23.76 mgGAE/g dry herbs, total flavonoids of 126.43 mgQE/g dry herbs, caffeine content of 29.87 mg caffeine/g dry herbs, apigenin levels of 0.07±0.068 µg/g dry herbs, and EGCG of 6.43±0.218 µg/g dry herbs. Functional beverages showed hypnotic activity in group of mice dosed 26 mL/kg bw, which significantly reduced motor activity to 4.83±0.72 sec. As well as significantly reducing the proinflammatory cytokines TNF-α and IL-6 to 3.17±0.53% and 5.08±0.35% (α=0.05), respectively.

show abstract

Neuropharmacological properties of Mikania scandens (L.) Willd. (Asteraceae)

Cited by 29 publications

References 6 publications

Antinociceptive, muscle relaxant and sedative activities of gold nanoparticles generated by methanolic extract of Euphorbia milii

Antinociceptive, muscle relaxant and sedative activities of gold nanoparticles generated by methanolic extract of Euphorbia milii

Evaluation of Analgesic, Anti-inflammatory and CNS Depressant Potential of Dendrophthoe falcata (Linn.) Leaves Extracts in Experimental Mice Model

Optimization formulation of chamomile-based functional beverage as hypnotic agent using response surface method

Contact Info

Product

Resources

About