Neuropharmacology of Sleep and Wakefulness

Watson, Christopher J.; Baghdoyan, Helen A.; Lydic, Ralph

doi:10.1016/j.jsmc.2012.06.010

Cited by 35 publications

(19 citation statements)

References 210 publications

(232 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compelling evidence suggests that sleep deprivation gives rise to deficiencies in these functions [7] , [8] , [9] . Sleep quality and related functions are regulated by internal neural networks [10] and external environmental factors, such as temperature [11] , light [12] , sound and smell [13] , [14] , [15] . Previous studies revealed that patients with obstructive sleep apnea experience a better sleep, with higher total sleep time and sleep efficiency, under a room temperature of 16°C compared to 24°C [11] .…”

Section: Introductionmentioning

confidence: 99%

Effects of Interface Pressure Distribution on Human Sleep Quality

Chen

Liu

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

High sleep quality promotes efficient performance in the following day. Sleep quality is influenced by environmental factors, such as temperature, light, sound and smell. Here, we investigated whether differences in the interface pressure distribution on healthy individuals during sleep influenced sleep quality. We defined four types of pressure models by differences in the area distribution and the subjective feelings that occurred when participants slept on the mattresses. One type of model was showed “over-concentrated” distribution of pressure; one was displayed “over-evenly” distributed interface pressure while the other two models were displayed intermediate distribution of pressure. A polysomnography analysis demonstrated an increase in duration and proportion of non-rapid-eye-movement sleep stages 3 and 4, as well as decreased number of micro-arousals, in subjects sleeping on models with pressure intermediately distributed compared to models with over-concentrated or over-even distribution of pressure. Similarly, higher scores of self-reported sleep quality were obtained in subjects sleeping on the two models with intermediate pressure distribution. Thus, pressure distribution, at least to some degree, influences sleep quality and self-reported feelings of sleep-related events, though the underlying mechanisms remain unknown. The regulation of pressure models imposed by external sleep environment may be a new direction for improving sleep quality. Only an appropriate interface pressure distribution is beneficial for improving sleep quality, over-concentrated or -even distribution of pressure do not help for good sleep.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of Interface Pressure Distribution on Human Sleep Quality

Chen

Liu

et al. 2014

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…A1 receptor‐mediated inhibition of cholinergic transmission in the basal forebrain induces sleep. At the pontine reticular formation, adenosine acts via the A2a receptor to enhance acetylcholine release, thereby increasing the amount of REM sleep (Watson et al ., ). The time spent in REM sleep was slightly elevated in our patient (28% REM sleep; Fig.…”

Section: Discussionmentioning

confidence: 97%

Hypersomnia with dilated pupils in adenosine monophosphate deaminase (AMPD) deficiency

Perumal

Kovač

Shah

et al. 2013

Journal of Sleep Research

View full text Add to dashboard Cite

“…The most widely studied intervention were the AChEIs likely due to a combination of theoretical, clinical and pragmatic reasons. Early neurochemical theories of sleep hypothesised Acetylcholine playing a primary role in wakefulness and REM sleep (Jouvet, 1972), further strengthened by later work underlying the muscarinic M2 receptor’s role in potentiating REM sleep (Baghdoyan & Lydic, 1999; Watson et al, 2012). Clinically, donepezil has been associated with vivid dreams and insomnia with higher incidences vs placebo reported in multiple studies (Burns et al, 1999; Pratt et al, 2002; Rogers et al, 1998) which alongside their common use in those with early cognitive impairment may have driven further research.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological and Non-Pharmacological Interventions to Enhance Sleep in Mild Cognitive Impairment and Mild Alzheimer’s Disease: A Systematic Review

Blackman

Swirski

Clynes

et al. 2020

Preprint

View full text Add to dashboard Cite

Suboptimal sleep causes cognitive decline and probably accelerates Alzheimer s Disease (AD) progression. Several sleep interventions have been tested in established AD dementia cases. However early intervention is needed in the course of AD at Mild Cognitive Impairment (MCI) or mild dementia stages to help prevent decline and maintain good quality of life. This systematic review aims to summarize evidence on sleep interventions in MCI and mild AD dementia. Seven databases were systematically searched for interventional studies where greater than 75% of participants met diagnostic criteria for MCI/mild AD dementia, with a control group and validated sleep outcome measures. Studies with a majority of participants diagnosed with Moderate to Severe AD were excluded. 20164 references were returned after duplication removal. 284 full papers were reviewed with 12 retained. Included papers reported 11 separate studies, total sample (n=602), mean age 76.3 years. Nine interventions were represented: Cognitive Behavioural Therapy Insomnia (CBT I), A Multi-Component Group Based Therapy, Phase Locked Loop Acoustic Stimulation, Melatonin, Donepezil, Galantamine, Rivastigmine, Tetrahydroaminoacridine and Continuous Positive Airway Pressure (CPAP). Psychotherapeutic approaches utilising adapted CBT-I achieved statistically significant improvements in the Pittsburgh Sleep Quality Index with one study reporting co-existent improved actigraphy variables. Melatonin significantly reduced sleep latency and sleep to wakefulness transitions in a small sample. CPAP demonstrated efficacy in participants with Obstructive Sleep Apnoea. Evidence to support other interventions was limited. There is a paucity of evidence for sleep interventions in MCI and mild AD highlighting a pressing need for high quality experimental studies exploring alternative sleep interventions.

show abstract

Neuropharmacology of Sleep and Wakefulness

Cited by 35 publications

References 210 publications

Effects of Interface Pressure Distribution on Human Sleep Quality

Effects of Interface Pressure Distribution on Human Sleep Quality

Hypersomnia with dilated pupils in adenosine monophosphate deaminase (AMPD) deficiency

Pharmacological and Non-Pharmacological Interventions to Enhance Sleep in Mild Cognitive Impairment and Mild Alzheimer’s Disease: A Systematic Review

Contact Info

Product

Resources

About