Neurophysiologic Studies of Depression: State of the Art

Kupfer, David J.; Reynolds, Charles F.

doi:10.1007/978-3-642-69129-4_15

Cited by 16 publications

(5 citation statements)

References 15 publications

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“…But they went on to postulate that such patients are using their pain as a defence against psychological truths or that such depressions only happen in patients of alexithymic disposition (Blumer and Heilbronn 1982). There is also a tradition of seeing the pain reported in depression as an attempt to expiate guilt (Kupfer and Reynolds 1983). In contrast, Healy and Williams (1987) and Angst (1973) suggest seeing this condition not as "masked depression par excellence" but as "naked" depression.…”

Section: Rhythmicity and Anhedoniamentioning

confidence: 99%

Rhythm and blues. Neurochemical, neuropharmacological and neuropsychological implications of a hypothesis of circadian rhythm dysfunction in the affective disorders

Healy

1987

Psychopharmacology

112

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Current views on the organisation and functions of the circadian rhythm system are outlined. Evidence is presented supportive of the notion that the pathophysiology of the affective disorders involves a disruption of circadian rhythms and that the primary locus of action of agents effective in the affective disorders is on the circadian rhythm system. Potential disruptions of this system are enumerated. Such a hypothesis, it is argued, might potentially unite the disparate neurochemical and neuroendocrinological findings emerging in both depression and mania. There are in addition neuropsychological and nosological implications of such a framework, which may help bridge the divide between molecular and behavioural approaches to research on the affective disorders which are outlined.

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Section: Rhythmicity and Anhedoniamentioning

confidence: 99%

Rhythm and blues. Neurochemical, neuropharmacological and neuropsychological implications of a hypothesis of circadian rhythm dysfunction in the affective disorders

Healy

1987

Psychopharmacology

112

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“…In addition, the sleep EEG of a depressed patient typically shows a decrease in rapid eye movement (REM) latency (the time between sleep onset and the beginning ofthe first REM period; this is also known as the first non-REM period), a redistribution of REM sleep with more REM activity in the first half of the night than normal, and a decrease in the amount of slow-wave sleep and deltawave activity. 4,9 Sleep is a time of considerable neuroendocrine activity.10 …”

mentioning

confidence: 99%

Recurrent Depression Is Associated With a Persistent Reduction in Sleep-Related Growth Hormone Secretion

Jarrett

Miewald²,

Kupfer³

1990

Arch Gen Psychiatry

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“…Serotonergic mechanisms in sleep regulation are of special importance in the context of depression, since alteration in both SW and REM sleep have been found consistently in depressed patients (28,29). There is agreement that serotonin is not an indispensable sleep neurohormone but discretely involved in ihe mediation of defined aspects of sleep (41) such as sleep latency, duration of sleep, and timing and distribution of REM episodes during the sleep cycle.…”

Section: Functional Aspects 01 Serotonin Neuronsmentioning

confidence: 99%

“…It also shortens the time spent in REM, and decreases the frequency of REM periods per sleep cycle (43). Zimelidine and all clinically effective TCA's have been found to restore shortened REM latency -one of the most consistent biological markers of depression-to near-normal values in humans besides improving the overall quality of sleep (29). This effect para!-leIs symptom relief and reflects remission in drug-free periods (29).…”

Section: Functional Aspects 01 Serotonin Neuronsmentioning

confidence: 99%

“…Zimelidine and all clinically effective TCA's have been found to restore shortened REM latency -one of the most consistent biological markers of depression-to near-normal values in humans besides improving the overall quality of sleep (29). This effect para!-leIs symptom relief and reflects remission in drug-free periods (29). These findings could suggest that at least certain aspects of sleep disturbances in depression might involve alterations in serotonin transmission.…”

Section: Functional Aspects 01 Serotonin Neuronsmentioning

confidence: 99%

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Anatomical Features and Physiological Properties of Central Serotonin Neurons

Lachenmayer²

1985

Pharmacopsychiatry

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The authors describe the anatomical features and physiological properties of central serotonergic neurons. The central serotonin neurons (part of which store peptides [substance P, TRF, enkephalins] in addition to 5HT) are highly collateralized reticular-type brain stem neurons receiving multi-modal afferent information from ascending sensory and descending motor pathways. They are under control by noradrenergic, peptidergic and and gaba-ergic projection neurons and interneurons. Furthermore, they establish variable synaptoid and synaptic contacts to neuronal, glial and secretory targets throughout the entire neuraxis and send terminal branches into the ventricular CSF space. Firing rate and transmission activity appear to be controlled in a complex and rather rigid manner by 5HT release-dependent dendrodendritic and dendrosomatic inhibition via autoreceptors (which also regulate release at the axon terminals) and via transsynaptic inhibitory feedback circuits which may involve gabaergic projection and interneurons. 3H-imipramine appears to bind to an "imipramine recognition site" in the vicinity of the 5HT carrier, and to a variety of other transport and (postsynaptic) receptor sites (NA uptake, H1, 5HT2- and alpha 1-binding sites). Circumstantial evidence points to an as yet undetermined role of the postsynaptic 5HT-1-binding sites in neurotransmission. 5HT-2-binding sites fulfil the criteria for receptors: binding affinity of antagonists to these sites correlates significantly with their potency to inhibit behavioral excitation in rats elicited by 5-hydroxytryptophan or 5HT agonists.(ABSTRACT TRUNCATED AT 250 WORDS)

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Neurophysiologic Studies of Depression: State of the Art

Cited by 16 publications

References 15 publications

Rhythm and blues. Neurochemical, neuropharmacological and neuropsychological implications of a hypothesis of circadian rhythm dysfunction in the affective disorders

Rhythm and blues. Neurochemical, neuropharmacological and neuropsychological implications of a hypothesis of circadian rhythm dysfunction in the affective disorders

Recurrent Depression Is Associated With a Persistent Reduction in Sleep-Related Growth Hormone Secretion

Anatomical Features and Physiological Properties of Central Serotonin Neurons

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