Neurophysiological alterations in the nucleus reuniens of a mouse model of Alzheimer's disease

Walsh, Darren; Brown, Jon; Randall, Andrew

doi:10.1016/j.neurobiolaging.2019.12.006

Cited by 5 publications

(1 citation statement)

References 50 publications

(69 reference statements)

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“…10,[14][15][16] Walsh found that nucleus reuniens of a mouse model of Alzheimer's disease exhibited an increased propensity to rebound burst following hyperpolarizing current stimuli, and this may contribute to hippocampalthalamo-cortical hyperexcitability. 17 In the peripheral nervous system (PNS), a small number of low-threshold mediumsized dorsal root ganglia (DRG) neurons also generate RF. 18,19 In neuropathic pain conditions, DRG neurons become hyperexcitable after DRG injury.…”

Section: Introductionmentioning

confidence: 99%

Post-Inhibitory Rebound Firing of Dorsal Root Ganglia Neurons

Zhu¹,

Wei²,

Wang³

2022

JPR

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Background: In the central nervous system, post-inhibitory rebound firing (RF) may mediate overactivity of neurons under pathophysiological condition. RF is also observed in dorsal root ganglion (IRA) neurons. However, the functional significance of RF in primary sensory neurons has remained unknown. After peripheral sensory nerve/neuron injury, DRG neurons exhibit hyperexcitability. Therefore, RF may play a role in neuropathic pain. Methods: Chronic compression of DRG (CCD) is used as a neuropathic pain model. Rats were divided into 2 groups: Sham and CCD groups. Patch clamp was performed on the whole DRG and cultured DRG neurons to record RF and T-type Ca 2+ currents. The blocker of T-type Ca 2+ channels, NiCl 2 , was applied to DRG neurons. Results: Rebound neurons were more excitable than non-rebound neurons. And they discharged RF with prominent after depolarizing potentials, which were blocked by NiCl 2 . After DRG injury, the proportion of rebound neurons augmented, and rebound neurons' excitability increased. Meanwhile, the steady-state activation curve of T-type Ca 2+ channels was shifted toward the left. Conclusion: RF may be related to highly excitable neurons and sensitive to both depolarization and hyperpolarization. T-type Ca 2+ channels were critical to RF, potentially enhancing the spontaneous firing of rebound neurons in response to resting membrane potential fluctuations.

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Section: Introductionmentioning

confidence: 99%

Post-Inhibitory Rebound Firing of Dorsal Root Ganglia Neurons

Zhu¹,

Wei²,

Wang³

2022

JPR

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Involvement of the Hypothalamic Nuclei in Forming Object–Place Associations in Neurons of Hippocampal Field CA2 (a hypothetical mechanism)

Силькис

2021

Neurosci Behav Physi

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A possible mechanism for the formation of representations of object-place associations in hippocampal neurons based on plastic rearrangements of the effi ciency of synaptic transmission, which depends on neuromodulators synthesized in neurons in various hypothalamic nuclei projecting to hippocampal fi eld CA2 is proposed. The afferent input from the supramammillary nucleus to fi eld CA2 promotes formation of representations of associations in neurons of fi elds CA2 and CA1, as it facilitates induction of long-term potentiation of transmission effi ciency in the CA2-CA1 pathway and summation of arousal arriving from fi elds CA3 and CA2 to CA1. Representations of object-place associations in fi eld CA2 include information on odors arriving in fi eld CA2 from the olfactory bulb via the paraventricular and supraoptic nuclei of the hypothalamus. Neurons in these nuclei synthesize vasopressin and oxytocin, which facilitate induction of long-term potentiation of synaptic inputs to pyramidal neurons in fi eld CA2, which promotes formation of representations of object-place associations on these neurons and their target cells in fi eld CA1, connected with the prefrontal cortex via the thalamic reuniens nucleus. As signals progress from the dentate gyrus through fi elds CA3 and CA2 to fi eld CA1, increasingly elaborate representations of object-place associations form in neurons in these areas. The unique nature of the connections of fi eld CA2 allow it to make a signifi cant contribution to encoding and memorizing not only contextual, but also social information. The consequences of the mechanism proposed here are consistent with results reported from experimental studies. An understanding of the mechanisms of hippocampus-dependent memory may be useful for targeted searches for drugs weakening those symptoms of Parkinson's disease and Alzheimer's disease induced by atrophy of pyramidal neurons in fi eld CA2.

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The thalamic midline nucleus reuniens: potential relevance for schizophrenia and epilepsy

Weel

2020

Neuroscience & Biobehavioral Reviews

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Neurophysiological alterations in the nucleus reuniens of a mouse model of Alzheimer's disease

Cited by 5 publications

References 50 publications

Post-Inhibitory Rebound Firing of Dorsal Root Ganglia Neurons

Post-Inhibitory Rebound Firing of Dorsal Root Ganglia Neurons

Involvement of the Hypothalamic Nuclei in Forming Object–Place Associations in Neurons of Hippocampal Field CA2 (a hypothetical mechanism)

The thalamic midline nucleus reuniens: potential relevance for schizophrenia and epilepsy

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