Neurophysiological correlates of sleepiness: A combined TMS and EEG study

Gennaro, Luigi De; Marzano, Cristina; Veniero, Domenica; Moroni, Fabio; Fratello, Fabiana; Curcio, Giuseppe; Ferrara, Michele; Ferlazzo, Fabio; Novelli, Luana; Pellicciari, Maria Concetta; Bertini, Mario; Rossini, Paolo Maria

doi:10.1016/j.neuroimage.2007.04.013

Cited by 116 publications

(100 citation statements)

References 52 publications

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“…In the last decade, the effects of total sleep deprivation on human motor cortex have been explored by means of TMS in normal individuals with conflicting results, mainly due to partial different methodological protocols utilized [17][18][19]45]. However, an increase in cortical excitability induced by total sleep deprivation has been documented by some studies in healthy subjects [17,18,46] as well as in epileptic patients [20,21,47].…”

Section: Discussionmentioning

confidence: 99%

Increased cortical excitability after selective REM sleep deprivation in healthy humans: A transcranial magnetic stimulation study

et al. 2013

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a b s t r a c tBackground: REM sleep has antiepileptogenic properties whereas, its loss is known to have a proconvulsive role. However, the mechanisms underlying the proepileptogenic effects of REM sleep deprivation are yet not fully understood. The aim of our study was to evaluate the effects of selective REM sleep deprivation (SRD) on cortical excitability in healthy subjects by means of transcranial magnetic stimulation (TMS). Methods: Ten normal subjects underwent three TMS sessions: (1) in baseline condition (BL), (2) after SRD by awakening them at each REM sleep onset and (3) after non-rapid eye movement sleep awakenings (NREM-A) as control for potential non-specific effects of interruptions. The TMS investigation included two protocols: (a) the evaluation of motor evoked potentials (MEPs) and silent period (SP) parameters, recorded in response to single pulse magnetic stimulation; (b) the evaluation of the time course of intracortical motor activity tested with paired-pulse TMS applied at inter-stimulus intervals of 1-10 ms. Results: After SRD the principal finding observed using single pulse TMS was a significant reduction in the duration of SP whereas, a reduction of intracortical inhibition was found, using the paired-pulse TMS. TMS parameters did not show significant changes after NREM-A with respect to BL. Conclusions: SRD may influence cortical excitability with a reduction of inhibitory intracortical mechanisms, thus supporting the proconvulsant role of REM loss.

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Section: Discussionmentioning

confidence: 99%

Increased cortical excitability after selective REM sleep deprivation in healthy humans: A transcranial magnetic stimulation study

et al. 2013

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“…Only a trend toward an increased cortical excitability was instead observed in healthy controls (Del Felice et al, 2011). Unfortunately, many conflicting views emerge when the studies on the influence of SD on TMS parameters in healthy controls are considered (Civardi et al, 2001;De Gennaro et al, 2007;Huber et al, 2013;Kreuzer et al, 2011;Manganotti et al, 2001;Placidi et al, 2013;Scalise et al, 2006).…”

Section: Experimental Studies On the Effects Of Sd On Cortical Excitamentioning

confidence: 99%

What is the role for EEG after sleep deprivation in the diagnosis of epilepsy? Issues, controversies, and future directions

Giorgi

Guida

Caciagli

et al. 2014

Neuroscience & Biobehavioral Reviews

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“…It is known that sleep deprivation can induce an increase in cortical excitability, probably related to modulations in the balance between inhibition and excitation at a cortical level (Scalise et al, 2006;Civardi et al, 2001;De Gennaro et al, 2007). Accordingly, a recent study has shown that the firing rate of cortical neurons increases with longer periods of wakefulness and decreases after being asleep (Vyazovskiy et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Effects of sleep deprivation on auditory change detection: a N1-Mismatch Negativity study

Bortoletto

Tona

Scozzari

et al. 2011

International Journal of Psychophysiology

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Neurophysiological correlates of sleepiness: A combined TMS and EEG study

Cited by 116 publications

References 52 publications

Increased cortical excitability after selective REM sleep deprivation in healthy humans: A transcranial magnetic stimulation study

Increased cortical excitability after selective REM sleep deprivation in healthy humans: A transcranial magnetic stimulation study

What is the role for EEG after sleep deprivation in the diagnosis of epilepsy? Issues, controversies, and future directions

Effects of sleep deprivation on auditory change detection: a N1-Mismatch Negativity study

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