Neurophysiological correlates of stereotypic behaviour in a model carnivore species

Díez-León, María; Kitchenham, Lindsey; Duprey, R.; Bailey, Craig D. C.; Choleris, Elena; Lewis, Mark H.; Mason, Georgia

doi:10.1016/j.bbr.2019.112056

Cited by 9 publications

(2 citation statements)

References 82 publications

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“…Furthermore, an enriched and more complex environment will reduce the occurrence of abnormal behaviors such as feather pecking in laying hens ( 61 ), locomotor stereotypies in mink ( 62 ), aggression and oral stereotypies in feedlot cattle ( 63 ) and oral stereotypies in dairy calves ( 64 ) which are all indicative of neural dysfunction ( 65 ). However, more research with livestock is needed to better understand the specific neural mechanisms of stereotypy development and how enrichment may exert its effect ( 66 ). Benefits are also not limited to just physical enrichments.…”

Section: Introductionmentioning

confidence: 99%

A Perspective on Strategic Enrichment for Brain Development: Is This the Key to Animal Happiness?

Campbell

2021

Front. Vet. Sci.

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Livestock animals are sentient beings with cognitive and emotional capacities and their brain development, similar to humans and other animal species, is affected by their surrounding environmental conditions. Current intensive production systems, through the restrictions of safely managing large numbers of animals, may not facilitate optimal neurological development which can contribute to negative affective states, abnormal behaviors, and reduce experiences of positive welfare states. Enrichment provision is likely necessary to enable animals to reach toward their neurological potential, optimizing their cognitive capacity and emotional intelligence, improving their ability to cope with stressors as well as experience positive affect. However, greater understanding of the neurological impacts of specific types of enrichment strategies is needed to ensure enrichment programs are effectively improving the individual's welfare. Enrichment programs during animal development that target key neurological pathways that may be most utilized by the individual within specific types of housing or management situations is proposed to result in the greatest positive impacts on animal welfare. Research within livestock animals is needed in this regard to ensure future deployment of enrichment for livestock animals is widespread and effective in enhancing their neurological capacities.

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Section: Introductionmentioning

confidence: 99%

A Perspective on Strategic Enrichment for Brain Development: Is This the Key to Animal Happiness?

Campbell

2021

Front. Vet. Sci.

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“…However, these treatments have not produced long-lasting effects or have provided minimal improvement. Consequently, there may be underlying factors that were not previously considered including complex mechanisms, such as basal ganglia dysfunction and cerebellum abnormalities in neurobiology aspect ( Bechard et al, 2016 ; Poirier and Bateson, 2017 ; Wilkes and Lewis, 2018 ; Díez-León et al, 2019 ), dysregulation of neurotransmitters ( Langen et al, 2011 ), or imbalance of intestinal flora ( Zheng et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Motor Stereotypic Behavior Was Associated With Immune Response in Macaques: Insight From Transcriptome and Gut Microbiota Analysis

et al. 2021

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Motor stereotypic behaviors (MSBs) are common in captive rhesus macaques (Macaca mulatta) and human with psychiatric diseases. However, large gaps remain in our understanding of the molecular mechanisms that mediate this behavior and whether there are similarities between human and non-human primates that exhibit this behavior, especially at gene expression and gut microbiota levels. The present study combined behavior, blood transcriptome, and gut microbiota data of two groups of captive macaques to explore this issue (i.e., MSB macaques with high MSB exhibition and those with low: control macaques). Observation data showed that MSB macaques spent the most time on MSB (33.95%), while the CONTROL macaques allocated more time to active (30.99%) and general behavior (30.0%), and only 0.97% of their time for MSB. Blood transcriptome analysis revealed 382 differentially expressed genes between the two groups, with 339 upregulated genes significantly enriched in inflammation/immune response-related pathway. We also identified upregulated pro-inflammatory genes TNFRSF1A, IL1R1, and IL6R. Protein–protein interaction network analysis screened nine hub genes that were all related to innate immune response, and our transcriptomic results were highly similar to findings in human psychiatric disorders. We found that there were significant differences in the beta-diversity of gut microbiota between MSB and CONTROL macaques. Of which Phascolarctobacterium, the producer of short chain fatty acids (SCFAs), was less abundant in MSB macaques. Meanwhile, PICRUSTs predicted that SCFAs intermediates biosynthesis and metabolic pathways were significantly downregulated in MSB macaques. Together, our study revealed that the behavioral, gene expression levels, and gut microbiota composition in MSB macaques was different to controls, and MSB was closely linked with inflammation and immune response. This work provides valuable information for future in-depth investigation of MSB and human psychiatric diseases.

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Stereotypic Behaviors in Managed Care

Vicino¹,

LAMBERSKI²

2023

Fowler' S Zoo and Wild Animal Medicine Current Therapy, Volume 10

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Neurophysiological correlates of stereotypic behaviour in a model carnivore species

Cited by 9 publications

References 82 publications

A Perspective on Strategic Enrichment for Brain Development: Is This the Key to Animal Happiness?

A Perspective on Strategic Enrichment for Brain Development: Is This the Key to Animal Happiness?

Motor Stereotypic Behavior Was Associated With Immune Response in Macaques: Insight From Transcriptome and Gut Microbiota Analysis

Stereotypic Behaviors in Managed Care

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