Neurophysiological Evidence of Corollary Discharge Dysfunction in Schizophrenia

Ford, Judith M.; Mathalon, Daniel H.; Heinks, Theda; Kalba, Sontine; Faustman, William O.; Roth, Walton T.

doi:10.1176/appi.ajp.158.12.2069

Cited by 282 publications

(284 citation statements)

References 12 publications

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“…If feedback matches the prediction, the sensory response is suppressed. Electroencephalography and magnetoencephalography (MEG) recordings have shown that auditory cortical responses to self-produced speech are attenuated when compared with responses to tape-recorded speech [1][2][3][4][5]. Similar phenomena are seen in the somatosensory system, where behavioral studies (e.g.…”

mentioning

confidence: 87%

Magnetoencephalographic evidence for a precise forward model in speech production

Heinks-Maldonado

Nagarajan²,

Houde³

2006

NeuroReport

166

162

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Electroencephalography and magnetoencephalography studies have shown that auditory cortical responses to self-produced speech are attenuated when compared with responses to tape-recorded speech, but that this attenuation disappears if auditory feedback is altered. These results suggest that auditory feedback during speaking is processed by comparing the feedback with its internal prediction. The present study used magnetoencephalography to investigate the precision of this matching process. Auditory responses to speech feedback were recorded under altered feedback conditions. During speech production, the M100 amplitude was maximally reduced to the participants' own unaltered voice feedback, relative to pitch-shifted and alien speech feed back. This suggests that the feedback comparison process may be very precise, allowing the auditory system to distinguish between internal and external sources of auditory information.Keywords altered feedback; efference copy; magnetoencephalography; speech production Theoretical backgroundData from a number of experiments suggest that the central nervous system processes sensory feedback from motor acts by comparing the feedback with a prediction of that feedback. This prediction, or corollary discharge, is the output of an internal (forward) model that maps motor commands (efference copy) to their expected sensory consequences. If feedback matches the prediction, the sensory response is suppressed. Electroencephalography and magnetoencephalography (MEG) recordings have shown that auditory cortical responses to self-produced speech are attenuated when compared with responses to tape-recorded speech [1][2][3][4][5]. Similar phenomena are seen in the somatosensory system, where behavioral studies (e.g. [6]) provide evidence for a precise forward model in which sensory stimulation has to correspond accurately to the movement producing it in

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mentioning

confidence: 87%

Magnetoencephalographic evidence for a precise forward model in speech production

Heinks-Maldonado

Nagarajan²,

Houde³

2006

NeuroReport

166

162

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“…CD deficits in schizophrenia could arise from the disrupted subcorticalthalamic-cortical circuits that are known to characterize the disease (Andreasen et al 1999). Schizophrenics are impaired in tasks requiring CD (Malenka et al 1986), and their auditory systems show particularly strong evidence for loss of CD-related modulation (Ford et al 2001(Ford et al , 2007. Neurophysiological assessment of CD circuits (e.g., the SC-MD-FEF pathway) could be performed in monkey models of schizophrenia as induced with dopaminergic or glutamatergic drugs (Condy et al 2005, Stone et al 2007 or fetal irradiation (Selemon et al 2005).…”

Section: And Human Diseasementioning

confidence: 99%

Brain Circuits for the Internal Monitoring of Movements

Sommer

Wurtz

2008

Annu. Rev. Neurosci.

464

387

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Each movement we make activates our own sensory receptors, thus causing a problem for the brain: the spurious, movement-related sensations must be discriminated from the sensory inputs that really matter, those representing our environment. Here we consider circuits for solving this problem in the primate brain. Such circuits convey a copy of each motor command, known as a corollary discharge (CD), to brain regions that use sensory input. In the visual system, CD signals may help to produce a stable visual percept from the jumpy images resulting from our rapid eye movements. A candidate pathway for providing CD for vision ascends from the superior colliculus to the frontal cortex in the primate brain. This circuit conveys warning signals about impending eye movements that are used for planning subsequent movements and analyzing the visual world. Identifying this circuit has provided a model for studying CD in other primate sensory systems and may lead to a better understanding of motor and mental disorders.

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“…In particular, masking noise has been shown to reduce stuttering (Maraist and Hutton, 1957), possibly due to the blockade of vocal feedback during speech. Corollary discharge mechanisms (Crapse and Sommer, 2008a,b), like those involved in vocalization-induced inhibition of the auditory cortex, are thought to be involved in the auditory hallucinations of schizophrenia as their absence may interfere with the differentiation between internal and external sources of auditory cortex activity (Ford et al, 2001a;van Lutterveld et al, 2011). Finally, patients with Parkinson's disease exhibit both decreased vocal amplitudes and a smaller magnitude of the Lombard effect (Ho et al, 1999), suggesting a component of their vocal disturbances may be related to the calculation of vocal feedback error in the basal ganglia, in particular the error in vocal amplitude, when presented with masking noise.…”

Section: Further Implications For Vocal Feedback Monitoringmentioning

confidence: 99%

Neural Correlates of the Lombard Effect in Primate Auditory Cortex

Eliades

Wang²

2012

Journal of Neuroscience

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Speaking is a sensory-motor process that involves constant self-monitoring to ensure accurate vocal production. Self-monitoring of vocal feedback allows rapid adjustment to correct perceived differences between intended and produced vocalizations. One important behavior in vocal feedback control is a compensatory increase in vocal intensity in response to noise masking during vocal production, commonly referred to as the Lombard effect. This behavior requires mechanisms for continuously monitoring auditory feedback during speaking. However, the underlying neural mechanisms are poorly understood. Here we show that when marmoset monkeys vocalize in the presence of masking noise that disrupts vocal feedback, the compensatory increase in vocal intensity is accompanied by a shift in auditory cortex activity toward neural response patterns seen during vocalizations under normal feedback condition. Furthermore, we show that neural activity in auditory cortex during a vocalization phrase predicts vocal intensity compensation in subsequent phrases. These observations demonstrate that the auditory cortex participates in self-monitoring during the Lombard effect, and may play a role in the compensation of noise masking during feedback-mediated vocal control.

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Neurophysiological Evidence of Corollary Discharge Dysfunction in Schizophrenia

Abstract: These findings provide direct neurophysiological evidence for a corollary discharge that dampens sensory responses to self-generated, relative to externally presented, percepts in healthy comparison subjects and its failure in patients with schizophrenia.

Cited by 282 publications

References 12 publications

Magnetoencephalographic evidence for a precise forward model in speech production

Magnetoencephalographic evidence for a precise forward model in speech production

Brain Circuits for the Internal Monitoring of Movements

Neural Correlates of the Lombard Effect in Primate Auditory Cortex

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