Neurophysiological Findings and Drinking Levels in High???Alcohol-Drinking (HAD) and Low???Alcohol-Drinking (LAD) Rats

Slawecki, Craig J.; Betancourt, Michelle; Tk, Li; Ehlers, and C. L.

doi:10.1097/00000374-200010000-00005

Cited by 8 publications

(25 citation statements)

References 53 publications

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“…High-alcohol drinking (HAD) rats demonstrated greater spectral power for the delta (2–6 Hz) and theta (4–6 Hz) bands compared to low-alcohol drinking (LAD) rats, with both groups specifically bred for their drinking proclivity. Further, HAD rats exhibited increased activity in the fast beta (13–30 Hz) and high-voltage fast alpha (9–12 Hz) bands [30]. These findings are consistent with EEG effects observed in binge drinkers who had not consumed alcohol at the frequency that is normally associated with alcoholism.…”

Section: Introductionsupporting

confidence: 62%

Binge Drinking Effects on EEG in Young Adult Humans

Courtney

Polich

2010

IJERPH

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Young adult (N = 96) university students who varied in their binge drinking history were assessed by electroencephalography (EEG) recording during passive viewing. Groups consisted of male and female non-binge drinkers (>1 to 5/4 drinks/ounces in under two hours), low-binge drinkers (5/4–7/6 drinks/ounces in under two hours), and high-binge drinkers (≥ 10 drinks/ounces in under two hours), who had been drinking alcohol at their respective levels for an average of 3 years. The non- and low-binge drinkers exhibited less spectral power than the high-binge drinkers in the delta (0–4 Hz) and fast-beta (20–35 Hz) bands. Binge drinking appears to be associated with a specific pattern of brain electrical activity in young adults that may reflect the future development of alcoholism.

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Section: Introductionsupporting

confidence: 62%

Binge Drinking Effects on EEG in Young Adult Humans

Courtney

Polich

2010

IJERPH

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“…al., 1994; Robledo, et al, 1994; Slawecki et. al., 2000b, 2001, 2003). Further research is needed to determine the functional significance of the increase in cortical peak frequencies in the δ and θ bands observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

Effects of adolescent ethanol exposure on sleep in adult rats

Criado

Wills

Walker

et al. 2008

Alcohol

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Although adolescent ethanol (EtOH) exposure has been associated with long-lasting changes in brain function, little is known as to whether EtOH exposure during adolescence alters sleep and cortical arousal. This study examined protracted alterations in sleep in adult rats exposed to EtOH during adolescence. Adolescent male Wistar rats were exposed to EtOH vapor for 12 hr/day for five weeks. Cortical electroencephalograms (EEGs) were obtained during 4-hr recording sessions after five weeks of withdrawal from EtOH. Adolescent EtOH exposure significantly reduced the mean duration of slow-wave sleep (SWS) episodes and the total amount of time spent in SWS in EtOH-exposed rats, compared to controls. Spectral analysis revealed that adolescent EtOH exposure significantly increased cortical peak frequencies during SWS in the 2-4 Hz, 4-6 Hz and 6-8 Hz bands. Taken together, our findings suggest that chronic EtOH exposure in adolescent rats reduces measures of SWS, an effect also seen as part of normal aging. Although the cellular and molecular mechanisms mediating the consequences of EtOH exposure on the aging process are not known, the similarities between adolescent EtOH exposure and aging merits further investigation.

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“…Although ethanol exposure through respiration does not mimic drinking in adolescent humans it does produce precise and stable blood ethanol levels (175-250 mg%) (see Slawecki et al, 2001) that are difficult to achieve in rodents drinking ethanol that are not selectively bred for high ethanol drinking. Moreover, our laboratory has used this technique to study the neurophysiological consequences of adolescent and adult ethanol exposure (e.g., Criado et al, 2008a, 2008b; Ehlers and Slawecki, 2000; Slawecki, 2002; Slawecki et al, 1999, 2000a, 2000b, 2001). Using this paradigm, we have investigated the effects of this ethanol exposure on ERPs.…”

Section: Effects Of Adolescent Ethanol Exposure On Erps In Rodentsmentioning

confidence: 99%

“…However, correlations of cortical peak frequencies with high ethanol consumption have not consistently correlated in rodent models of high ethanol consumption, compared to their low drinking counterparts (e.g., Katner, et al, 2002; Morzorati, et. al., 1994; Robledo, et al, 1994; Slawecki et. al., 2000b, 2001, 2003).…”

Section: Effects Of Adolescent Ethanol Exposure On Eeg and Sleep In Rmentioning

confidence: 99%

Adolescent ethanol exposure: does it produce long-lasting electrophysiological effects?

Ehlers

Criado

2010

Alcohol

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This review discusses evidence for long lasting neurophysiological changes that may occur following exposure to ethanol during adolescent development in animal models. Adolescence is the time that most individuals first experience ethanol exposure and binge drinking is not uncommon during adolescence. If alcohol exposure is neurotoxic to the developing brain during adolescence, not unlike it is during fetal development, then understanding how ethanol affects the developing adolescent brain becomes a major public health issue. Adolescence is a critical time period when cognitive, emotional and social maturation occurs and it is likely that ethanol exposure may affect these complex processes. In order to study the effects of ethanol on adolescent brain animal models where the dose and time of exposure can be carefully controlled that closely mimic the human condition are needed. The studies reviewed provide evidence that demonstrates that relatively brief exposure to high levels of ethanol, via ethanol vapours, during a period corresponding to parts of adolescence in the rat is sufficient to cause long-lasting changes in functional brain activity. Disturbances in waking EEG and a reduction in the P3 component of the ERP have been demonstrated in adult rats that were exposed to ethanol vapour during adolescence. Adolescent ethanol exposure was also found to produce long lasting reductions in the mean duration of slow-wave sleep (SWS) episodes and the total amount of time spent in SWS, a finding consistent with a premature aging of sleep. Further studies are necessary to confirm these findings, in a range of strains, and to link those findings to the neuroanatomical and neurochemical mechanisms potentially underlying the lasting effects of adolescent ethanol exposure. KeywordsAdolescence; EEG; ERPs; Ethanol; Sleep Adolescence a developmental epoch at high risk for initiation of ethanol useAdolescence is a developmental period of enormous strength and resilience. As compared to young children adolescents are bigger, faster, and stronger and are achieving the apex of their SP30-1501, La Jolla, CA 29037, Tel: (858) Fax: (858) 784-7409, cindye@scripps.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptAlcohol. Author manuscript; available in PMC 2011 January 1. capacity to withstand cold, injury, heat, and physical stress and are achieving maturational improvements in reaction time, reasoning abilities and immune function (Arnett, 1999;Dahl, 2004;Tanner, 1989). Adolescence is also a time for an increase in the tendencies toward se...

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Neurophysiological Findings and Drinking Levels in High???Alcohol-Drinking (HAD) and Low???Alcohol-Drinking (LAD) Rats

Abstract: These data suggest there are some similarities in EEG and ERP profiles of P and HAD rats compared with NP and LAD rats. Furthermore, the data suggest that decreased P300 amplitude in the amygdala is associated with increased limited access ethanol drinking.

Cited by 8 publications

References 53 publications

Binge Drinking Effects on EEG in Young Adult Humans

Binge Drinking Effects on EEG in Young Adult Humans

Effects of adolescent ethanol exposure on sleep in adult rats

Adolescent ethanol exposure: does it produce long-lasting electrophysiological effects?

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