2008
DOI: 10.1016/j.ijpsycho.2008.05.364
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Neurophysiological mechanisms of excessive compensatory recruitment of neuronal pools in Early Alzheimer's Disease as compared to mild vascular dementia and normal aging

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Cited by 1 publication
(3 citation statements)
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“…Our present findings with the Topographic Mapping of ERPs to our Memory Workload Paradigm, with larger samples, replicate and expand our previous results (Beuzeron -Mangina and Mangina, 1998, 2000a,b, 2004, 2008. As such, normal aging is characterized by shorter anterior P450 latencies and longer latencies over posterior areas.…”
Section: Discussionsupporting
confidence: 91%
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“…Our present findings with the Topographic Mapping of ERPs to our Memory Workload Paradigm, with larger samples, replicate and expand our previous results (Beuzeron -Mangina and Mangina, 1998, 2000a,b, 2004, 2008. As such, normal aging is characterized by shorter anterior P450 latencies and longer latencies over posterior areas.…”
Section: Discussionsupporting
confidence: 91%
“…Thus, the lack of recruitment found in our MVD patients might also be explained by the fact that these long neuronal pathways were sufficiently preserved to allow patients to process the demanding memory load tasks of our paradigm without excessive physiological effort as opposed to VEAD patients. Hence, it is plausible that in VEAD, the excessive recruitment of compensatory neuronal pools becomes a compulsory neurophysiological mechanism to meet the demanding tasks of our Memory Workload Paradigm (Beuzeron- Mangina and Mangina, 1998, 2000a,b, 2004, 2008, Mangina and Sokolov, 2006. In fact, in our pilot investigations, the phenomenon of a compensatory recruitment was observable only in the very early stages Alzheimer's disease, and it was not visible in the more advanced stages of this illness.…”
Section: Discussionmentioning
confidence: 69%
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