Neuropilin-1 as a Potential Biomarker of Prognosis and Invasive-Related Parameters in Liver and Colorectal Cancer: A Systematic Review and Meta-Analysis of Human Studies

Fernández-Palanca, Paula; Payo-Serafín, Tania; Fondevila, Flavia; Méndez-Blanco, Carolina; San‐Miguel, Beatriz; Romero, Marta R.; Tuñón, María J.; Marin, José J.G.; González‐Gallego, Javier; Mauriz, José L.

doi:10.3390/cancers14143455

Cited by 9 publications

(11 citation statements)

References 55 publications

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“…40 Additionally, a systematic review indicated that NRP1 is a potentially useful biomarker for HCC, and that its overexpression is significantly related to both disease development and lower survival rates, as well as an elevated risk of vascular invasion and metastasis. 41 Flavia et al verified the substantial link between the high expression of FOXO3 and the risk of invasion as a novel biomarker in HCC, as well as its diagnostic and prognostic utility in another review encompassing 1059 HCC cases. 42 In an HCC investigation, researchers also developed an immune-related model made up of 11 genes, which can both identify prognostic stratification and offer a fresh viewpoint for the search for immunotherapeutic medicines.…”

Section: Discussionmentioning

confidence: 97%

Expression of CKS2 in Hepatocellular Carcinoma: Correlation with Survival Outcomes and Immune Microenvironment

Zhi,

Hao,

et al. 2023

JHC

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Cyclin-dependent kinase regulatory subunit 2 (CKS2) has an important function in regulating cancer progression and cell cycle. This research aims to ascertain how CKS2 plays its part through multi-omics analyses, to reveal its relationship with the immune microenvironment in hepatocellular carcinoma (HCC). Material and Methods: Multiple databases were used to determine the transcriptional data of CKS2, epigenetic changes, and effects thereof upon the prognosis of HCC patients. The biological functions of CKS2 in HCC were expounded by functional enrichment analysis. TIMER, GSEA, TIP, and online single-cell sequencing databases were adopted for revealing correlations of CKS2 expression with infiltration of immune cells, immunomodulators, immunity cycle, and immune markers in the immune microenvironment of HCC. In addition, qRT-PCR and Western blot were used to validate gene expression in tissues from HCC patients. Results: Open database analysis confirmed that CKS2 is highly expressed in HCC and that it is related to poor prognosis in HCC patients. Aberrant methylation levels of the two methylation sites of CKS2 in HCC contributed to its high expression and were correlated significantly with survival. The CKS2 expression was positively correlated with most immunomodulators and infiltration levels for B and CD8+T cells, dendritic cells, and macrophages, especially exhausted CD8+T cells. Besides, the CKS2 expression was also found to have significant correlations with immunity cycle steps and diverse immune markers in HCC. The high CKS2 expression was confirmed in HCC at both mRNA and protein levels, showing a significant increase compared to normal tissue. Conclusion: CKS2 is a potential prognostic biomarker of HCC and can promote the progression of HCC via its influences on the immune environment. Additionally, a positive correlation between CKS2 and immune markers was observed, highlighting its potential as an immunotherapeutic target.

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Section: Discussionmentioning

confidence: 97%

Expression of CKS2 in Hepatocellular Carcinoma: Correlation with Survival Outcomes and Immune Microenvironment

Zhi,

Hao,

et al. 2023

JHC

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“…NRP-1 has been overexpressed in various cancer types, including lung, breast, pancreatic, and prostate cancers. NRP-1 affects cell survival, migration, and attraction by binding to ligands and various co-receptors and may serve as a cancer biomarker of refractory tumors ( 25 ).…”

Section: Nrp Signalingmentioning

confidence: 99%

Revealing neuropilin expression patterns in pancreatic cancer: From single‑cell to therapeutic opportunities (Review)

Meng,

Hara,

Sato

et al. 2024

Oncol Lett

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Pancreatic cancer, one of the most fatal types of human cancers, includes several non-epithelial and stromal components, such as activated fibroblasts, vascular cells, neural cells and immune cells, that are involved in different cancers. Vascular endothelial cell growth factor 165 receptors 1 [neuropilin-1 ( NRP-1 )] and 2 ( NRP-2 ) play a role in the biological behaviors of pancreatic cancer and may appear as potential therapeutic targets. The NRP family of proteins serve as co-receptors for vascular endothelial growth factor, transforming growth factor β, hepatocyte growth factor, fibroblast growth factor, semaphorin 3, epidermal growth factor, insulin-like growth factor and platelet-derived growth factor. Investigations of mechanisms that involve the NRP family of proteins may help develop novel approaches for overcoming therapy resistance in pancreatic cancer. The present review aimed to provide an in-depth exploration of the multifaceted roles of the NRP family of proteins in pancreatic cancer, including recent findings from single-cell analysis conducted within the context of pancreatic adenocarcinoma, which revealed the intricate involvement of NRP proteins at the cellular level. Through these efforts, the present study endeavored to further reveal their relationships with different biological processes and their potential as therapeutic targets in various treatment modalities, offering novel perspectives and directions for the treatment of pancreatic cancer.

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“…The identification of useful biomarkers is one of the main objectives to increase the rate of early diagnosis in the HCC landscape 8 . In this line, several investigations have found an overexpression of NRP1 in the tumor tissue of patients diagnosed with HCC compared to the healthy liver tissue [76][77][78][79][80][81][82][83][84][85] . Similar results were also described in preclinical studies, showing increased NRP1 levels in different HCC cell lines with respect to the normal liver L02 cell line 85,86 .…”

Section: Nrp1 As a Biomarkermentioning

confidence: 96%

“…Similar results were also described in preclinical studies, showing increased NRP1 levels in different HCC cell lines with respect to the normal liver L02 cell line 85,86 . Although fewer investigations have analyzed the potential use of NRP1 as serum biomarker, positive findings have been also published 79,87 , highlighting the potential role of this NRP receptor in the diagnostic field of HCC [76][77][78][79][80][81][82][83][84][85][86][87] .…”

Section: Nrp1 As a Biomarkermentioning

confidence: 99%

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Study of the role of neuropilin-1 in the development, prognosis and cellular response to lenvatinib in human hepatocellular carcinoma

Fernández Palanca

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Con esta memoria termina mi etapa predoctoral y, con ello, empieza un nuevo camino en mi carrera investigadora que no habría llegado sin todas esas personas que me habéis ayudado y habéis hecho que esto sea posible.En primer lugar, quiero agradecer a mis directores de tesis, José y Javier, por haberme permitido realizar esta Tesis Doctoral en su grupo, por todo el apoyo y por la confianza que he recibido durante estos años. Esta oportunidad me ha permitido aprender y crecer profesionalmente, así como introducirme en el mundo de la ciencia acompañada de dos grandes investigadores. Sin duda, no habría podido encontrar mejor grupo en el que comenzar mi carrera investigadora y docente.A todos mis compañeros del Área de Fisiología del Departamento de Ciencias Biomédicas. Gracias por todos los momentos, la ayuda y lo que he aprendido durante esta etapa, sobre todo durante las prácticas. Habéis hecho que mi paso por el Área haya sido enriquecedor tanto a nivel académico como profesional.Por supuesto, a todos mis compañeros de laboratorio del IBIOMED, todos los que habéis pasado por él y hemos compartido charlas. Porque sois muchos los que estabais cuando empecé y también los que continuáis, que habéis hecho de mi paso por el laboratorio una etapa inolvidable, llena de buenos recuerdos y mucho aprendizaje. Sin duda habéis contribuido a mi crecimiento personal y profesional. En especial agradecer a Brisa por todas las charlas constructivas, a María, Sara, Marta y Esther, mis compañeras de despacho, a Bea y María Jesús por su confianza y apoyo, y sobre todo a Rebeca, por ayudarme siempre en todo lo que podía.Especial mención merecen mis compañeras Carolina y Flavia, qué deciros que no sepáis.Gracias por haberme enseñado todo lo que sabéis y por todos los momentos, sobre todo buenos, que hemos compartido y vivido estos años. Mi paso por el IBIOMED no habría sido lo mismo sin vosotras. Y a Tania como no, porque, aunque acaba de empezar, lo ha hecho con muchas ganas y me ha contagiado la motivación durante esta última etapa del doctorado, quizás la más dura. Junto con Jenny, muchas gracias por querer formar parte de este grupo.

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Neuropilin-1 as a Potential Biomarker of Prognosis and Invasive-Related Parameters in Liver and Colorectal Cancer: A Systematic Review and Meta-Analysis of Human Studies

Cited by 9 publications

References 55 publications

Expression of CKS2 in Hepatocellular Carcinoma: Correlation with Survival Outcomes and Immune Microenvironment

Expression of CKS2 in Hepatocellular Carcinoma: Correlation with Survival Outcomes and Immune Microenvironment

Revealing neuropilin expression patterns in pancreatic cancer: From single‑cell to therapeutic opportunities (Review)

Study of the role of neuropilin-1 in the development, prognosis and cellular response to lenvatinib in human hepatocellular carcinoma

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