Neuropilin-2 Is Associated With Increased Hepatoblastoma Cell Viability and Motility

Eloranta, Katja; Nousiainen, Ruth; Cairo, Stefano; Pakarinen, Mikko P.; Wilson, David B.; Pihlajoki, Marjut; Heikinheimo, Markku

doi:10.3389/fped.2021.660482

Cited by 3 publications

(2 citation statements)

References 61 publications

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“…Conversely, miR-130a-3p transfection showed activation of some crucial signaling pathways for tumor development. Among the commonly deregulated genes, we found a significant up-regulation of the Rac Family Small GTPase 1 ( RAC1 ) gene and neuropilin 2 ( NRP2 ), which are involved in tumor migration and invasion in different tumors [ 38 ] including lung cancer [ 39 , 40 ]. In particular, Rac1 protein participates in the membrane protrusion formation, driving tumor cell migration [ 41 ] and the formation of membrane ruffles [ 42 ], also implicated in the metastatic potential of tumor cells [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

A Circulating Risk Score, Based on Combined Expression of Exo-miR-130a-3p and Fibrinopeptide A, as Predictive Biomarker of Relapse in Resectable Non-Small Cell Lung Cancer Patients

Marconi

Croce

Chiorino

et al. 2022

Cancers

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To date, the 5-year overall survival rate of 60% for early-stage non-small cell lung cancer (NSCLC) is still unsatisfactory. Therefore, reliable prognostic factors are needed. Growing evidence shows that cancer progression may depend on an interconnection between cancer cells and the surrounding tumor microenvironment; hence, circulating molecules may represent promising markers of cancer recurrence. In order to identify a prognostic score, we performed in-depth high-throughput analyses of plasma circulating markers, including exosomal microRNAs (Exo-miR) and peptides, in 67 radically resected NSCLCs. The miRnome profile selected the Exo-miR-130a-3p as the most overexpressed in relapsed patients. Peptidome analysis identified four progressively more degraded forms of fibrinopeptide A (FpA), which were depleted in progressing patients. Notably, stepwise Cox regression analysis selected Exo-miR-130a-3p and the greatest FpA (2-16) to build a score predictive of recurrence, where high-risk patients had 18 months of median disease-free survival. Moreover, in vitro transfections showed that higher levels of miR-130a-3p lead to a deregulation of pathways involved in metastasis and angiogenesis, including the coagulation process and metalloprotease increase which might be linked to FpA reduction. In conclusion, by integrating circulating markers, the identified risk score may help clinicians predict early-stage NSCLC patients who are more likely to relapse after primary surgery.

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Section: Discussionmentioning

confidence: 99%

A Circulating Risk Score, Based on Combined Expression of Exo-miR-130a-3p and Fibrinopeptide A, as Predictive Biomarker of Relapse in Resectable Non-Small Cell Lung Cancer Patients

Marconi

Croce

Chiorino

et al. 2022

Cancers

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“…NRP2 expression is also observed in hepatoblastoma (HB) patients and HB cell lines. NRP2 silencing in HB cell lines decreased their viability and their migration, indicating its indispensable role in HB progression [112].…”

Section: Liver Cancermentioning

confidence: 99%

Role of Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance

Islam

Mishra

Bodas

et al. 2022

Cancer Metastasis Rev

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Neuropilins (NRPs) are transmembrane proteins involved in vascular and nervous system development by regulating angiogenesis and axon guidance cues. Several published reports have established their role in tumorigenesis. NRPs are detectable in tumor cells of several cancer types and participate in cancer progression. NRP2 is also expressed in endothelial and immune cells in the tumor microenvironment and promotes functions such as lymphangiogenesis and immune suppression important for cancer progression. In this review, we have taken a comprehensive approach to discussing various aspects of NRP2-signaling in cancer, including its regulation, functional significance in cancer progression, and how we could utilize our current knowledge to advance the studies and target NRP2 to develop effective cancer therapies.

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Biology of childhood hepatoblastoma and the search for novel treatments

Pihlajoki,

Eloranta,

Nousiainen

et al. 2024

Advances in Biological Regulation

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Neuropilin-2 Is Associated With Increased Hepatoblastoma Cell Viability and Motility

Cited by 3 publications

References 61 publications

A Circulating Risk Score, Based on Combined Expression of Exo-miR-130a-3p and Fibrinopeptide A, as Predictive Biomarker of Relapse in Resectable Non-Small Cell Lung Cancer Patients

A Circulating Risk Score, Based on Combined Expression of Exo-miR-130a-3p and Fibrinopeptide A, as Predictive Biomarker of Relapse in Resectable Non-Small Cell Lung Cancer Patients

Role of Neuropilin-2-mediated signaling axis in cancer progression and therapy resistance

Biology of childhood hepatoblastoma and the search for novel treatments

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