2012
DOI: 10.1111/j.1369-1600.2012.00470.x
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Neuroplasticity, axonal guidance and micro‐RNA genes are associated with morphine self‐administration behavior

Abstract: Neuroadaptations in the ventral striatum (VS) and ventral midbrain (VMB) following chronic opioid administration are thought to contribute to the pathogenesis and persistence of opiate addiction. In order to identify candidate genes involved in these neuroadaptations we utilized a behavior genetics strategy designed to associate contingent intravenous drug self-administration with specific patterns of gene expression in inbred mice differentially predisposed to the rewarding effects of morphine. In a yoked-con… Show more

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Cited by 47 publications
(47 citation statements)
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“…Optogenetic experiments further define the role of these neuronal subtypes, with D1, but not D2, MSNs mediating tolerance and reward [81,82]. Transcriptional and proteomic profiles outline morphine-induced changes in phosphorylation cascades, energy status, and cell morphology [83,84]. It is unclear if the cellular adaptations observed in the striatum are restricted to opioid receptor-expressing cells or are a result of pass-forward allostasis (Box 2).…”
Section: Allostatic Processes In Striatal Cells Signaling and Circuitsmentioning
confidence: 99%
“…Optogenetic experiments further define the role of these neuronal subtypes, with D1, but not D2, MSNs mediating tolerance and reward [81,82]. Transcriptional and proteomic profiles outline morphine-induced changes in phosphorylation cascades, energy status, and cell morphology [83,84]. It is unclear if the cellular adaptations observed in the striatum are restricted to opioid receptor-expressing cells or are a result of pass-forward allostasis (Box 2).…”
Section: Allostatic Processes In Striatal Cells Signaling and Circuitsmentioning
confidence: 99%
“…Mu opioids such as morphine modulate expression of a number of miRNAs (Sanchez-Simon et al, 2010;Zheng et al, 2010;Wu et al, 2008Wu et al, , 2013Dave and Khalili, 2010;He et al, 2010;Wang et al, 2011), and several miRNAs regulate MOR-1 expression (Wu et al, 2008(Wu et al, , 2009He et al, 2010). Dysregulation of miRNAs has been linked to morphine tolerance and addiction Dreyer, 2010;Hwang et al, 2012;Tapocik et al, 2013). Yet there has been a lack of information regarding miRNA Fig.…”
Section: Introductionmentioning
confidence: 99%
“…Opioid dose is a poor predictor 13 ; some factors that have been associated with NAS severity include: cooccurring exposure to benzodiazepines, 14,15 anti-depressants, 16,17 marijuana use or heavy smoking, 18,19 as well as genetic factors. 24,25 MiRNAs are highly regulated by exposure to drugs of abuse [26][27][28][29][30][31] and emerging evidence also suggests that they play an important role in the etiology of addiction. Further, decisions to initiate pharmacotherapy rely partly on subjective observer-rated scoring.…”
Section: Introductionmentioning
confidence: 99%
“…20,21 None of these factors are sufficient to reliably predict NAS severity, and the mechanisms by which they impact NAS are not well understood. [27][28][29][31][32][33] Specifically, opioid consumption drastically alters the miRNA landscape in the brain. Biomarkers indicative of individual fetal brain responses to opioid exposure would be invaluable to augment observer-rated assessments that guide pharmacotherapy decision-making and contribute to personalized risk assessments for mothers antenatally.…”
Section: Introductionmentioning
confidence: 99%
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